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Escherichia coli K-12 substr. MG1655 Compound: p-chloromercuriphenylsulfonate

Synonyms: p-chloromercuriphenyl sulphonate, p-chloromercuriphenyl sulphonic acid, p-CMPSA, p-chloromercuriphenylsulphonate, PCMBS, 4-chloromercuribenzenesulfonate, p-chloromercuribenzenesulfonate

Chemical Formula: C6H4O3SClHg

Molecular Weight: 392.2 Daltons

Monoisotopic Molecular Weight: 393.93541842679997 Daltons

SMILES: C1(C=CC(=CC=1)S(=O)([O-])=O)[Hg]Cl

InChI: InChI=1S/C6H5O3S.ClH.Hg/c7-10(8,9)6-4-2-1-3-5-6;;/h2-5H,(H,7,8,9);1H;/q;;+1/p-2

InChIKey: InChIKey=XXEBDPRHFAWOND-UHFFFAOYSA-L

Unification Links: ChEBI:33207 , ChemSpider:4574181 , PubChem:5460705

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -64.78

Enzymes inhibited by p-chloromercuriphenylsulfonate, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: glycerol-3-phosphate dehydrogenase, anaerobic [Schryvers81] , D-glucarate dehydratase [Blumenthal66] , glycerol-3-phosphate:phosphate antiporter [Fann03] , sulfite reductase [Siegel74] , GDP-mannose 4,6-dehydratase [Elbein65]


References

Blumenthal66: Blumenthal H "D-Glucarate Dehydrase." Meth Enz 1966;9:660-665.

Elbein65: Elbein AD, Heath EC (1965). "The Biosynthesis of Cell Wall Lipopolysaccharide in Escherichia coli. II. Guanosine diphosphate 4-keto-6-deoxy-D-mannose, an intermediate in the biosynthesis of guanosine diphosphate colitose." J Biol Chem 240:1926-1931. PMID: 14299611

Fann03: Fann MC, Busch A, Maloney PC (2003). "Functional characterization of cysteine residues in GlpT, the glycerol 3-phosphate transporter of Escherichia coli." J Bacteriol 185(13);3863-70. PMID: 12813080

Schryvers81: Schryvers A, Weiner JH (1981). "The anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia coli. Purification and characterization." J Biol Chem 1981;256(19);9959-65. PMID: 6792201

Siegel74: Siegel LM, Davis PS, Kamin H (1974). "Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow." J Biol Chem 1974;249(5);1572-86. PMID: 4150390


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc12.