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Escherichia coli K-12 substr. MG1655 Compound: guanylyl molybdenum cofactor

Synonyms: MGD, MPT-GMP, MoO2(OH)Dtpp-mGDP, molybdopterin guanine dinucleotide

Superclasses: a cofactor a prosthetic group
an organic heterocyclic compound an organic heterobicyclic compound a pteridine a pterin a Mo-molybdopterin cofactor
an organic heterocyclic compound an organonitrogen heterocyclic compound a pteridine a pterin a Mo-molybdopterin cofactor

Summary from MetaCyc:
The name MoO2(OH)Dtpp-mGDP has been suggested as the systematic name for this compound [Fischer98a].

Chemical Formula: C20H22N10O15P2S2Mo

Molecular Weight: 864.46 Daltons

Monoisotopic Molecular Weight: 867.9393323539 Daltons

guanylyl molybdenum cofactor compound structure

SMILES: C(OP(=O)([O-])OP(=O)([O-])OCC3(O[CH]1(NC4(N=C(N)NC(=O)C(N[CH]1C2(=C(S[Mo](=O)(=O)S2)3))=4))))C5(OC(C(O)C(O)5)N7(C=NC6(C(=O)NC(N)=NC=67)))

InChI: InChI=1S/C20H26N10O13P2S2.Mo.2O/c21-19-26-13-7(15(33)28-19)24-6-12(47)11(46)5(41-17(6)25-13)2-40-45(37,38)43-44(35,36)39-1-4-9(31)10(32)18(42-4)30-3-23-8-14(30)27-20(22)29-16(8)34;;;/h3-6,9-10,17-18,24,31-32,46-47H,1-2H2,(H,35,36)(H,37,38)(H3,22,27,29,34)(H4,21,25,26,28,33);;;/q;+2;;/p-4/t4-,5-,6+,9-,10-,17-,18-;;;/m1.../s1

InChIKey: InChIKey=RQPREYSMTBNTJA-JNXJJIQFSA-J

Unification Links: ChEBI:71310 , PubChem:50986239

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -655.688

Reactions known to produce the compound:

guanylyl molybdenum cofactor biosynthesis :
MoO2-molybdopterin cofactor + GTP + H+guanylyl molybdenum cofactor + diphosphate

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: nitrate reductase , formate dehydrogenase-O


References

Fischer98a: Fischer B, Enemark JH, Basu P (1998). "A chemical approach to systematically designate the pyranopterin centers of molybdenum and tungsten enzymes and synthetic models." J Inorg Biochem 72(1-2);13-21. PMID: 9861725


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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