Escherichia coli K-12 substr. MG1655 Compound: 2-phosphoglycolate

Synonyms: 2-P-glycolate, phosphoglycolate, Phosphoglycolic acid

Chemical Formula: C2H2O6P

Molecular Weight: 153.01 Daltons

Monoisotopic Molecular Weight: 155.9823744031 Daltons

2-phosphoglycolate compound structure

SMILES: C(OP([O-])(=O)[O-])C([O-])=O

InChI: InChI=1S/C2H5O6P/c3-2(4)1-8-9(5,6)7/h1H2,(H,3,4)(H2,5,6,7)/p-3


Unification Links: ChEBI:58033, HMDB:HMDB00816, IAF1260:36550, KEGG:C00988, MetaboLights:MTBLC58033, PubChem:24916760

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -335.48

Reactions known to consume the compound:

Not in pathways:
2-phosphoglycolate + H2O → glycolate + phosphate

Enzymes inhibited by 2-phosphoglycolate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: triosephosphate isomerase [Alvarez98], glycerol-3-phosphate dehydrogenase, aerobic [Schryvers78], methylglyoxal synthase [Saadat98]

In Growth Media: PMA phosphorus source test + 2-phosphoglycolate


Alvarez98: Alvarez M, Zeelen JP, Mainfroid V, Rentier-Delrue F, Martial JA, Wyns L, Wierenga RK, Maes D (1998). "Triose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus. Kinetic and structural properties." J Biol Chem 273(4);2199-206. PMID: 9442062

Saadat98: Saadat D, Harrison DH (1998). "Identification of catalytic bases in the active site of Escherichia coli methylglyoxal synthase: cloning, expression, and functional characterization of conserved aspartic acid residues." Biochemistry 1998;37(28);10074-86. PMID: 9665712

Schryvers78: Schryvers A, Lohmeier E, Weiner JH (1978). "Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of Escherichia coli." J Biol Chem 253(3);783-8. PMID: 340460

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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