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Escherichia coli K-12 substr. MG1655 Compound Class: a glycerophosphoinositol

Superclasses: a lipid a phospholipid a phosphoglyceride

Summary:
A glycerophosphoinositol is the name given to any phosphoglyceride having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone. Unlike phosphatidylinositol, it may contain either one or two fatty acids.

Child Classes: a phosphatidylinositol (0)

SMILES: C(OC(=O)[R1])C(COP(=O)([O-])OC1(C(O)C(O)C(O)C(O)C(O)1))OC(=O)[R2]

Unification Links: ChEBI:36315

Reactions known to consume the compound:

Not in pathways:
a phospholipid + (KDO)2-lipid A → a glycerol ester + hepta-acylated KDO2-lipid A

In Reactions of unknown directionality:

Not in pathways:
a diacylglycerol prolipoprotein[periplasmic space] + a phospholipid[periplasmic space] = murein lipoprotein[periplasmic space] + a lysophospholipid[periplasmic space]

Enzymes activated by a glycerophosphoinositol, sorted by the type of activation, are:

Activator (Allosteric) of: pyruvate oxidase [Cunningham75, Chang84]

Activator (Mechanism unknown) of: CTP:2,3,4-saturated L-phosphatidate cytidylyltransferase [Langley78a] , cytochrome bo terminal oxidase [Kita84a] , L-lactate dehydrogenase [Kimura78] , D-lactate dehydrogenase [Fung79] , cytochrome bd-I terminal oxidase [Kita84]

Credits:
Created 14-Oct-2009 by Kothari A , SRI International


References

Chang84: Chang YY, Cronan JE (1984). "An Escherichia coli mutant deficient in pyruvate oxidase activity due to altered phospholipid activation of the enzyme." Proc Natl Acad Sci U S A 81(14);4348-52. PMID: 16593486

Cunningham75: Cunningham CC, Hager LP (1975). "Reactivation of the lipid-depleted pyruvate oxidase system from Escherichia coli with cell envelope neutral lipids." J Biol Chem 250(18);7139-46. PMID: 1100621

Fung79: Fung LW, Pratt EA, Ho C (1979). "Biochemical and biophysical studies on the interaction of a membrane-bound enzyme, D-lactate dehydrogenase from Escherichia coli, with phospholipids." Biochemistry 1979;18(2);317-24. PMID: 369600

Kimura78: Kimura H, Futai M (1978). "Effects of phospholipids on L-lactate dehydrogenase from membranes of Escherichia coli. Activation and stabilization of the enzyme with phospholipids." J Biol Chem 1978;253(4);1095-110. PMID: 342518

Kita84: Kita K, Konishi K, Anraku Y (1984). "Terminal oxidases of Escherichia coli aerobic respiratory chain. II. Purification and properties of cytochrome b558-d complex from cells grown with limited oxygen and evidence of branched electron-carrying systems." J Biol Chem 1984;259(5);3375-81. PMID: 6321507

Kita84a: Kita K, Konishi K, Anraku Y (1984). "Terminal oxidases of Escherichia coli aerobic respiratory chain. I. Purification and properties of cytochrome b562-o complex from cells in the early exponential phase of aerobic growth." J Biol Chem 1984;259(5);3368-74. PMID: 6365921

Langley78a: Langley KE, Kennedy EP (1978). "Partial purification and properties of CTP:phosphatidic acid cytidylyltransferase from membranes of Escherichia coli." J Bacteriol 1978;136(1);85-95. PMID: 30751


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc14.