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Escherichia coli K-12 substr. MG1655 Compound: Cu2+

Synonyms: Cu+2, Cu++, cupric ion, cupric copper, Cu(II)

Superclasses: an ion a cation

Component of:
copper sulfate pentahydrate
copper sulfate

Chemical Formula: Cu

Molecular Weight: 63.546 Daltons

Monoisotopic Molecular Weight: 62.9296011 Daltons

SMILES: [Cu++]

InChI: InChI=1S/Cu/q+2

InChIKey: InChIKey=JPVYNHNXODAKFH-UHFFFAOYSA-N

Unification Links: ChEBI:29036 , ChemSpider:25221 , HMDB:HMDB00657 , IAF1260:50600 , PubChem:27099

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

Reactions known to produce the compound:

Not in pathways:
4 Cu+[periplasmic space] + 4 H+[periplasmic space] + oxygen[periplasmic space] → 4 Cu2+[periplasmic space] + 2 H2O[periplasmic space]

In Reactions of unknown directionality:

Not in pathways:
Cu2+ + NADH = Cu+ + NAD+ + H+

In Transport reactions:
Cu2+[periplasmic space]Cu2+[cytosol]

Enzymes inhibited by Cu2+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: cytosine deaminase [Porter93, Comment 1]

Inhibitor (Mechanism unknown) of: N-acetyl-β-neuraminate lyase [Aisaka91, Uchida84] , glyoxalase [Subedi11] , NADPH-dependent curcumin reductase [Hassaninasab11] , guanosine kinase [Mori95] , inosine kinase [Mori95] , glutaminase [Hartman68] , 7-α-hydroxysteroid dehydrogenase [Yoshimoto91] , L-serine deaminase [Newman80a] , S-formylglutathione hydrolase [Gonzalez06a] , S-formylglutathione hydrolase [Gonzalez06a] , mannose isomerase [Itoh08] , deoxyribose 1,5-phosphomutase [HammerJespersen70] , 3'-nucleotidase [Anraku64] , glutamate decarboxylase B [Helmward89] , crotonobetainyl-CoA reductase [Roth94] , 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Ray80] , glycogen phosphorylase [Chen68a, Chen68] , N-acetylglutamylphosphate reductase [Vogel74] , trimethylamine N-oxide reductase [Shimokawa79, Silvestro88] , 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase [Ray80a] , methylglyoxal reductase (NADPH-dependent) [Saikusa87] , allantoinase [Kim00c] , hydrogenase [Ballantine86] , acetylornithine deacetylase [Vogel74a] , glutamate-5-semialdehyde dehydrogenase [Hayzer82] , D-glucuronate isomerase [Ashwell60] , D-galacturonate isomerase [Ashwell60] , glyoxylate carboligase [Gupta66] , acetylornithine aminotransferase [Vogel74b] , N-acetylneuraminate lyase [Aisaka91, Uchida84] , dipeptidyl carboxypeptidase [Henrich93] , threonine dehydrogenase [Boylan81, Craig86] , tetrahydrodipicolinate succinylase [Simms84] , amylomaltase [Wiesmeyer60] , polyphosphate kinase [Haeusler92] , glutamate decarboxylase A [Helmward89] , N-acetylglutamate synthase [Marvil77] , lactaldehyde dehydrogenase [Sridhara69, Baldoma87] , glycerol dehydrogenase [Tang79] , lipoyl-adenylate--protein ligase [Green95] , taurine dioxygenase [Eichhorn97] , 2',3'-cyclic nucleotide 2'-phosphodiesterase [Anraku64] , D-aminopropanol dehydrogenase [Kelley84, Campbell78] , 2-amino-3-ketobutyrate CoA ligase [Mukherjee87]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: cytochrome bo terminal oxidase , phenylethylamine oxidase , amine oxidase , examinopeptidase , superoxide dismutase

In Growth Media: MOPS medium with 2% glycerol , MOPS medium with 2% glucose , MOPS medium with 0.4% glucose , MOPS medium base , Neidhardt EZ rich defined medium , trace metal solution , LB enriched


References

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Anraku64: Anraku Y (1964). "A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. I. Purification and some properties of the enzyme." J Biol Chem 1964;239(10):3412-3419. PMID: 14245396

Ashwell60: Ashwell G, Wahba AJ, Hickman J (1960). "Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli." J Biol Chem 1960;235(6):1559-1565. PMID: 13794771

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Itoh08: Itoh T, Mikami B, Hashimoto W, Murata K (2008). "Crystal structure of YihS in complex with D-mannose: structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase." J Mol Biol 377(5);1443-59. PMID: 18328504

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Kim00c: Kim GJ, Lee DE, Kim HS (2000). "Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli." J Bacteriol 2000;182(24);7021-8. PMID: 11092864

Marvil77: Marvil DK, Leisinger T (1977). "N-acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties." J Biol Chem 1977;252(10);3295-303. PMID: 16890

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Mukherjee87: Mukherjee JJ, Dekker EE (1987). "Purification, properties, and N-terminal amino acid sequence of homogeneous Escherichia coli 2-amino-3-ketobutyrate CoA ligase, a pyridoxal phosphate-dependent enzyme." J Biol Chem 1987;262(30);14441-7. PMID: 3117785

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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