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Escherichia coli K-12 substr. MG1655 Compound: Hg2+

Synonyms: Hg++, Hg(II), mercury ion, mercury (II)

Superclasses: an ion a cation

Citations: [S89]

Chemical Formula: Hg

Molecular Weight: 200.59 Daltons

Monoisotopic Molecular Weight: 201.970626 Daltons

SMILES: [Hg++]

InChI: InChI=1S/Hg/q+2

InChIKey: InChIKey=BQPIGGFYSBELGY-UHFFFAOYSA-N

Unification Links: ChEBI:16793 , ChemSpider:24800 , HMDB:HMDB03625 , IAF1260:35741 , KEGG:C00703 , PubChem:26623

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

Enzymes inhibited by Hg2+, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: fumarase A [Xu12] , phenylethylamine oxidase [Roh94] , NADPH-dependent curcumin reductase [Hassaninasab11] , phosphatidylglycerophosphatase [Funk92] , glutaminase [Hartman68] , 7-α-hydroxysteroid dehydrogenase [Yoshimoto91] , isocitrate lyase , rhamnulose-1-phosphate aldolase [Chiu75] , glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase [Jeanningros76] , betaine aldehyde dehydrogenase [Falkenberg90] , diffusion of glycerol [Maurel94] , glyoxylate carboligase [Gupta66] , glutamate decarboxylase B [Helmward89] , crotonobetainyl-CoA reductase [Roth94] , 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Ray80, Comment 1] , glycogen phosphorylase [Chen68a, Chen68] , 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase [Ray80a] , glutathione S-transferase [Arca90] , 4-aminobutyrate transaminase [Schulz90] , threonine dehydrogenase [Craig86] , o-succinylbenzoate-CoA ligase [Kwon96] , amylomaltase [Wiesmeyer60] , glutamate decarboxylase A [Helmward89] , D-arabinose 5-phosphate isomerase [Meredith03] , glycolate oxidase [Lord72] , N-acetylglutamate synthase [Marvil77] , D-aminopropanol dehydrogenase [Kelley84, Comment 2] , 2-amino-3-ketobutyrate CoA ligase [Mukherjee87]


References

Arca90: Arca P, Garcia P, Hardisson C, Suarez JE (1990). "Purification and study of a bacterial glutathione S-transferase." FEBS Lett 1990;263(1);77-9. PMID: 2185038

Chen68: Chen GS, Segel IH (1968). "Purification and properties of glycogen phosphorylase from Escherichia coli." Arch Biochem Biophys 1968;127(1);175-86. PMID: 4878695

Chen68a: Chen GS, Segel IH (1968). "Escherichia coli polyglucose phosphorylases." Arch Biochem Biophys 1968;127(1);164-74. PMID: 4878694

Chiu75: Chiu TH, Evans KL, Feingold DS (1975). "L-Rhamnulose-1-phosphate aldosase." Methods Enzymol 1975;42;364-9. PMID: 237196

Craig86: Craig PA, Dekker EE (1986). "L-threonine dehydrogenase from Escherichia coli K-12: thiol-dependent activation by Mn2+." Biochemistry 1986;25(8);1870-6. PMID: 3518793

Falkenberg90: Falkenberg P, Strom AR (1990). "Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli." Biochim Biophys Acta 1990;1034(3);253-9. PMID: 2194570

Funk92: Funk CR, Zimniak L, Dowhan W (1992). "The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase." J Bacteriol 1992;174(1);205-13. PMID: 1309518

Gupta66: Gupta NK, Vennesland B (1966). "Glyoxylate carboligase of Escherichia coli: some properties of the enzyme." Arch Biochem Biophys 1966;113(2);255-64. PMID: 5328735

Hartman68: Hartman SC (1968). "Glutaminase of Escherichia coli. I. Purification and general catalytic properties." J Biol Chem 1968;243(5);853-63. PMID: 4966660

Hassaninasab11: Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M (2011). "Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism." Proc Natl Acad Sci U S A 108(16):6615-20. PMID: 21467222

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

Jeanningros76: Jeanningros R, Creuzet-Sigal N, Frixon C, Cattaneo J (1976). "Purification and properties of a debranching enzyme from Escherichia coli." Biochim Biophys Acta 1976;438(1);186-99. PMID: 779849

Kelley84: Kelley JJ, Dekker EE (1984). "D-1-amino-2-propanol:NAD+ oxidoreductase. Purification and general properties of the large molecular form of the enzyme from Escherichia coli K12." J Biol Chem 1984;259(4);2124-9. PMID: 6365902

Kwon96: Kwon O, Bhattacharyya DK, Meganathan R (1996). "Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and properties of o-succinylbenzoyl-coenzyme A synthetase from Escherichia coli." J Bacteriol 1996;178(23);6778-81. PMID: 8955296

Lord72: Lord JM (1972). "Glycolate oxidoreductase in Escherichia coli." Biochim Biophys Acta 1972;267(2);227-37. PMID: 4557653

Marvil77: Marvil DK, Leisinger T (1977). "N-acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties." J Biol Chem 1977;252(10);3295-303. PMID: 16890

Maurel94: Maurel C, Reizer J, Schroeder JI, Chrispeels MJ, Saier MH (1994). "Functional characterization of the Escherichia coli glycerol facilitator, GlpF, in Xenopus oocytes." J Biol Chem 269(16);11869-72. PMID: 7512955

Meredith03: Meredith TC, Woodard RW (2003). "Escherichia coli YrbH is a D-arabinose 5-phosphate isomerase." J Biol Chem 278(35);32771-7. PMID: 12805358

Mukherjee87: Mukherjee JJ, Dekker EE (1987). "Purification, properties, and N-terminal amino acid sequence of homogeneous Escherichia coli 2-amino-3-ketobutyrate CoA ligase, a pyridoxal phosphate-dependent enzyme." J Biol Chem 1987;262(30);14441-7. PMID: 3117785

Ray80: Ray PH (1980). "Purification and characterization of 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli." J Bacteriol 1980;141(2);635-44. PMID: 6988389

Ray80a: Ray PH, Benedict CD (1980). "Purification and characterization of specific 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Escherichia coli B." J Bacteriol 1980;142(1);60-8. PMID: 6246070

Roh94: Roh JH, Suzuki H, Azakami H, Yamashita M, Murooka Y, Kumagai H (1994). "Purification, characterization, and crystallization of monoamine oxidase from Escherichia coli K-12." Biosci Biotechnol Biochem 58(9);1652-6. PMID: 7765483

Roth94: Roth S, Jung K, Jung H, Hommel RK, Kleber HP (1994). "Crotonobetaine reductase from Escherichia coli--a new inducible enzyme of anaerobic metabolization of L(-)-carnitine." Antonie Van Leeuwenhoek 1994;65(1);63-9. PMID: 8060125

S89: S. Budavari, Editor, M.J. O'Neil, Associate Editor, A. Smith, Assistant Editor, P. E. Heckelman, Editorial Assistant "The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. Eleventh Edition." Merck & Co., Inc. Rahway, NJ, 1989.

Schulz90: Schulz A, Taggeselle P, Tripier D, Bartsch K (1990). "Stereospecific production of the herbicide phosphinothricin (glufosinate) by transamination: isolation and characterization of a phosphinothricin-specific transaminase from Escherichia coli." Appl Environ Microbiol 1990;56(1);1-6. PMID: 2178550

Wiesmeyer60: Wiesmeyer H, Cohn M (1960). "The characterization of the pathway of maltose utilization by Escherichia coli: II. General properties and mechanism of action of amylomaltase." Biochim Biophys Acta 39:427-439. PMID: 13844669

Xu12: Xu FF, Imlay JA (2012). "Silver(I), mercury(II), cadmium(II), and zinc(II) target exposed enzymic iron-sulfur clusters when they toxify Escherichia coli." Appl Environ Microbiol 78(10);3614-21. PMID: 22344668

Yoshimoto91: Yoshimoto T, Higashi H, Kanatani A, Lin XS, Nagai H, Oyama H, Kurazono K, Tsuru D (1991). "Cloning and sequencing of the 7 alpha-hydroxysteroid dehydrogenase gene from Escherichia coli HB101 and characterization of the expressed enzyme." J Bacteriol 1991;173(7);2173-9. PMID: 2007545


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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