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Escherichia coli K-12 substr. MG1655 Compound: hydroxylamine

Synonyms: NH2OH

Chemical Formula: H3NO

Molecular Weight: 33.03 Daltons

Monoisotopic Molecular Weight: 33.0214637236 Daltons

hydroxylamine compound structure

SMILES: NO

InChI: InChI=1S/H3NO/c1-2/h2H,1H2

InChIKey: InChIKey=AVXURJPOCDRRFD-UHFFFAOYSA-N

Unification Links: CAS:7803-49-8 , ChEBI:15429 , ChemSpider:766 , HMDB:HMDB03338 , KEGG:C00192 , MetaboLights:MTBLC15429 , PubChem:787

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -39.46

Reactions known to consume the compound:

Not in pathways:
ammonium + an oxidized unknown electron acceptor + H2O ← hydroxylamine + an reduced unknown electron acceptor + H+

Enzymes inhibited by hydroxylamine, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: 3-chloro-D-alanine dehydrochlorinase [Nagasawa85] , phenylethylamine oxidase [Roh94] , aspartate 1-decarboxylase [Cronan80] , ubiquinol oxidase (H+-transporting) [Kita86, Helmward89] , phosphatidylserine decarboxylase [Comment 1] , 4-aminobutyrate transaminase [Schulz90] , N-succinyldiaminopimelate aminotransferase [Peterkofsky61] , cytochrome bd-I terminal oxidase [Kita86, Helmward89]

This compound has been characterized as an alternative substrate of the following enzymes: nitrite reductase - NADH dependent , dimethyl sulfoxide reductase

In Growth Media: PMA nitrogen source test + hydroxylamine


References

Cronan80: Cronan JE (1980). "Beta-alanine synthesis in Escherichia coli." J Bacteriol 1980;141(3);1291-7. PMID: 6767707

Dowhan92: Dowhan W, Li QX (1992). "Phosphatidylserine decarboxylase from Escherichia coli." Methods Enzymol 1992;209;348-59. PMID: 1495415

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

Kita86: Kita K, Konishi K, Anraku Y (1986). "Purification and properties of two terminal oxidase complexes of Escherichia coli aerobic respiratory chain." Methods Enzymol 1986;126;94-113. PMID: 2856144

Nagasawa85: Nagasawa T, Ishii T, Kumagai H, Yamada H (1985). "D-Cysteine desulfhydrase of Escherichia coli. Purification and characterization." Eur J Biochem 1985;153(3);541-51. PMID: 3908101

Peterkofsky61: Peterkofsky B, Gilvarg C (1961). "N-Succinyl-L-diaminopimelic-glutamic transaminase." J Biol Chem 236;1432-8. PMID: 13734750

Roh94: Roh JH, Suzuki H, Azakami H, Yamashita M, Murooka Y, Kumagai H (1994). "Purification, characterization, and crystallization of monoamine oxidase from Escherichia coli K-12." Biosci Biotechnol Biochem 58(9);1652-6. PMID: 7765483

Satre78: Satre M, Kennedy EP (1978). "Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli." J Biol Chem 1978;253(2);479-83. PMID: 338609

Schulz90: Schulz A, Taggeselle P, Tripier D, Bartsch K (1990). "Stereospecific production of the herbicide phosphinothricin (glufosinate) by transamination: isolation and characterization of a phosphinothricin-specific transaminase from Escherichia coli." Appl Environ Microbiol 1990;56(1);1-6. PMID: 2178550


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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