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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Compound: inosine

Synonyms: hypoxanthine-ribose, iso-prinosine, riboxine

Superclasses: a nucleic acid component a nucleoside a purine nucleoside a purine ribonucleoside
a nucleic acid component a nucleoside a ribonucleoside a purine ribonucleoside
an organic heterocyclic compound an organic heterobicyclic compound a purine a purine nucleoside a purine ribonucleoside
an organic heterocyclic compound an organonitrogen heterocyclic compound a purine a purine nucleoside a purine ribonucleoside

Chemical Formula: C10H12N4O5

Molecular Weight: 268.23 Daltons

Monoisotopic Molecular Weight: 268.08076951649997 Daltons

SMILES: C(O)C1(OC(C(O)C(O)1)N3(C=NC2(C(=O)NC=NC=23)))

InChI: InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

InChIKey: InChIKey=UGQMRVRMYYASKQ-KQYNXXCUSA-N

Unification Links: CAS:58-63-9 , ChEBI:17596 , ChemSpider:5799 , HMDB:HMDB00195 , IAF1260:34525 , KEGG:C00294 , MetaboLights:MTBLC17596 , PubChem:6021

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -143.539

Reactions known to consume the compound:

adenine and adenosine salvage V :
inosine + ATP → IMP + ADP + H+

Not in pathways:
inosine + H2O → D-ribofuranose + hypoxanthine

Reactions known to produce the compound:

adenine and adenosine salvage III , adenine and adenosine salvage V , adenosine nucleotides degradation II , purine ribonucleosides degradation :
adenosine + H+ + H2O → ammonium + inosine

Not in pathways:
IMP + H2O → inosine + phosphate


a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate
a nucleoside 3'-phosphate + H2O → a ribonucleoside + phosphate


a nucleoside 5'-monophosphate[periplasmic space] + H2O[periplasmic space]a nucleoside[periplasmic space] + phosphate[periplasmic space]

Reactions known to both consume and produce the compound:

adenine and adenosine salvage III , adenosine nucleotides degradation II , purine ribonucleosides degradation :
inosine + phosphate ↔ α-D-ribose-1-phosphate + hypoxanthine

Not in pathways:
a purine ribonucleoside + phosphate ↔ a purine base + α-D-ribose-1-phosphate

In Transport reactions:
inosine[periplasmic space] + H+[periplasmic space]inosine[cytosol] + H+[cytosol] ,
inosine[cytosol] + H+[periplasmic space]inosine[periplasmic space] + H+[cytosol] ,
a nucleoside[extracellular space]a nucleoside[periplasmic space] ,
a nucleoside[periplasmic space] + H+[periplasmic space]a nucleoside[cytosol] + H+[cytosol]

Enzymes inhibited by inosine, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: acid phosphatase / phosphotransferase [Thaller97]

In Growth Media: Gutnick minimal salts medium base + inosine , PMA nitrogen source test + inosine , PMA carbon source test + inosine


References

Thaller97: Thaller MC, Schippa S, Bonci A, Cresti S, Rossolini GM (1997). "Identification of the gene (aphA) encoding the class B acid phosphatase/phosphotransferase of Escherichia coli MG1655 and characterization of its product." FEMS Microbiol Lett 1997;146(2);191-8. PMID: 9011040


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc14.