Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Compound: Li+

Synonyms: lithium ion

Superclasses: an ion a cation

Chemical Formula: Li

Molecular Weight: 6.941 Daltons

Monoisotopic Molecular Weight: 7.016004 Daltons

SMILES: [Li+]

InChI: InChI=1S/Li/q+1

InChIKey: InChIKey=HBBGRARXTFLTSG-UHFFFAOYSA-N

Unification Links: ChEBI:49713 , ChemSpider:26502 , DrugBank:DB01356 , HMDB:HMDB05949 , PubChem:28486

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

In Transport reactions:
Li+[periplasmic space] + melibiose[periplasmic space]Li+[cytosol] + melibiose[cytosol]

Enzymes activated by Li+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: adenosylmethionine decarboxylase [Lu07]

Enzymes inhibited by Li+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: rhamnulose-1-phosphate aldolase [Chiu69, Comment 1]

Inhibitor (Mechanism unknown) of: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Heinemeyer78] , 2-acylglycerophosphoethanolamine acyltransferase [Comment 2] , fructose-1,6-bisphosphatase [Brown09] , fructose 1,6-bisphosphatase [Brown09] , adenosine-3'(2'),5'-bisphosphate nucleotidase [Mechold06] , inositol monophosphatase [Matsuhisa95, Chen00c, Comment 3]


References

Brown09: Brown G, Singer A, Lunin VV, Proudfoot M, Skarina T, Flick R, Kochinyan S, Sanishvili R, Joachimiak A, Edwards AM, Savchenko A, Yakunin AF (2009). "Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli." J Biol Chem 284(6);3784-92. PMID: 19073594

Chen00c: Chen L, Roberts MF (2000). "Overexpression, purification, and analysis of complementation behavior of E. coli SuhB protein: comparison with bacterial and archaeal inositol monophosphatases." Biochemistry 2000;39(14);4145-53. PMID: 10747806

Chiu69: Chiu TH, Feingold DS (1969). "L-rhamnulose 1-phosphate aldolase from Escherichia coli. Crystallization and properties." Biochemistry 1969;8(1);98-108. PMID: 4975916

Heinemeyer78: Heinemeyer EA, Richter D (1978). "Characterization of the guanosine 5'-triphosphate 3'-diphosphate and guanosine 5'-diphosphate 3'-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli." Biochemistry 1978;17(25);5368-72. PMID: 365225

Lu07: Lu ZJ, Markham GD (2007). "Metal ion activation of S-adenosylmethionine decarboxylase reflects cation charge density." Biochemistry 46(27);8172-80. PMID: 17567041

Matsuhisa95: Matsuhisa A, Suzuki N, Noda T, Shiba K (1995). "Inositol monophosphatase activity from the Escherichia coli suhB gene product." J Bacteriol 1995;177(1);200-5. PMID: 8002619

Mechold06: Mechold U, Ogryzko V, Ngo S, Danchin A (2006). "Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells." Nucleic Acids Res 34(8);2364-73. PMID: 16682444

Rock84: Rock CO (1984). "Turnover of fatty acids in the 1-position of phosphatidylethanolamine in Escherichia coli." J Biol Chem 1984;259(10);6188-94. PMID: 6373752


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc13.