Escherichia coli K-12 substr. MG1655 Compound: D-mannitol

Synonyms: D-mitobronitol

Superclasses: all carbohydratesa carbohydratea glycana sugara sugar alcohola hexitol
an alcohola sugar alcohola hexitol

Component of: MtlR-mannitol

Chemical Formula: C6H14O6

Molecular Weight: 182.17 Daltons

Monoisotopic Molecular Weight: 182.079038182 Daltons

D-mannitol compound structure


InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1


Unification Links: CAS:69-65-8, ChEBI:16899, ChemSpider:6015, DrugBank:DB00742, HMDB:HMDB00765, IAF1260:34845, KEGG:C00392, MetaboLights:MTBLC16899, PubChem:6251

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -225.44

Reactions known to produce the compound:

Not in pathways:
a sugar phosphate + H2O → a sugar + phosphate

β-D-glucuronide and D-glucuronate degradation :
a β-D-glucuronoside + H2O → D-glucopyranuronate + an alcohol

glycerophosphodiester degradation :
a glycerophosphodiester + H2O → an alcohol + sn-glycerol 3-phosphate + H+

Not in pathways:
an organic hydroperoxide + NADH + H+an alcohol + NAD+ + H2O
an N-acetyl-β-D-hexosaminide + H2O → an N-acetyl-β-D-hexosamine + an alcohol
a carboxylic ester + H2O → an alcohol + a carboxylate + H+
an acetic ester + H2O → an alcohol + acetate + H+
an organic hydroperoxide + a reduced thioredoxin → an alcohol + an oxidized thioredoxin + H2O
a phosphate monoester[periplasm] + H2O[periplasm]an alcohol[periplasm] + phosphate[periplasm]
a phosphate monoester[periplasm] + H2O[periplasm]an alcohol[periplasm] + phosphate[periplasm]

In Reactions of unknown directionality:

Not in pathways:
MtlR + D-mannitol = MtlR-mannitol

Not in pathways:
an alcohol + NADP+ = an aldehyde + NADPH + H+

In Transport reactions:
HPr-Phis15 + D-mannitol[periplasm] → D-mannitol 1-phosphate[cytosol] + HPr,
a sugar alcohol[periplasm]a sugar alcohol[extracellular space],
a [PTS enzyme I]-Nπ-phospho-L-histidine + a sugar[periplasm] → a [PTS enzyme I]-L-histidine + a sugar phosphate[cytosol]

Enzymes inhibited by D-mannitol, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: D-mannonate dehydratase [RobertBaudouy73]

This compound has been characterized as an alternative substrate of the following enzymes: diffusion of glycerol

In Growth Media: PMA carbon source test + D-mannitol


RobertBaudouy73: Robert-Baudouy JM, Stoeber FR (1973). "[Purification and properties of D-mannonate hydrolyase from Escherichia coli K12]." Biochim Biophys Acta 1973;309(2);473-85. PMID: 4581499

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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