Escherichia coli K-12 substr. MG1655 Compound: methylmethanethiosulfonate

Synonyms: MMTS

Chemical Formula: C2H6O2S2

Molecular Weight: 126.19 Daltons

Monoisotopic Molecular Weight: 125.9809208168 Daltons

methylmethanethiosulfonate compound structure


InChI: InChI=1S/C2H6O2S2/c1-5-6(2,3)4/h1-2H3


Unification Links: ChEBI:74357, ChemSpider:17065, HMDB:HMDB31832, MetaboLights:MTBLC74357, PubChem:18064

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -67.21

Enzymes inhibited by methylmethanethiosulfonate, sorted by the type of inhibition, are:

Inhibitor (Irreversible) of: pyruvate oxidase [Koland82] Inhibitor (Mechanism unknown) of: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase [Schirch85], tRNA-guanine transglycosylase [Garcia97]


Garcia97: Garcia GA, Chong S (1997). "Cysteine 265 is in the active site of, but is not essential for catalysis by tRNA-guanine transglycosylase (TGT) from Escherichia coli." J Protein Chem 16(1);11-7. PMID: 9055203

Koland82: Koland JG, Gennis RB (1982). "Identification of an active site cysteine residue in Escherichia coli pyruvate oxidase." J Biol Chem 257(11);6023-7. PMID: 7042705

Schirch85: Schirch V, Hopkins S, Villar E, Angelaccio S (1985). "Serine hydroxymethyltransferase from Escherichia coli: purification and properties." J Bacteriol 1985;163(1);1-7. PMID: 3891721

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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