Escherichia coli K-12 substr. MG1655 Compound: Mn2+

Synonyms: manganese ion, Mn(II), Mn+2, Mn++, manganese (II) ion

Superclasses: an ion a cation

Component of:
manganese chloride
manganese sulfate pentahydrate

Chemical Formula: Mn

Molecular Weight: 54.938 Daltons

Monoisotopic Molecular Weight: 54.9380496 Daltons

SMILES: [Mn++]

InChI: InChI=1S/Mn/q+2


Unification Links: CAS:7439-96-5 , CAS:16397-91-4 , ChEBI:29035 , ChemSpider:25916 , HMDB:HMDB01333 , IAF1260:33594 , KEGG:C19610 , PubChem:27854

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

In Reactions of unknown directionality:

Not in pathways:
MntR[membrane] + Mn2+[membrane] = MntR-Mn2+[membrane]

In Transport reactions:
Mn2+[periplasmic space]Mn2+[cytosol] ,
Mn2+[cytosol]Mn2+[periplasmic space] ,
Mn2+[periplasmic space] + H+[periplasmic space]Mn2+[cytosol] + H+[cytosol]

Enzymes activated by Mn2+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: cysteinylglycine dipeptidase [Suzuki01] , adenosylmethionine decarboxylase [Lu07] , cyclic di-GMP phosphodiesterase [Lacey10] , D-altronate dehydratase [Dreyer87] , glutaminase B [Prusiner76] , D-mannonate oxidoreductase [Portalier72] , D-mannonate dehydratase [RobertBaudouy73, Dreyer87] , threonine dehydrogenase [Comment 1] , polyphosphate kinase [Ahn90, Haeusler92, Comment 2] , trimethylamine N-oxide reductase [Sagai73] , proline aminopeptidase [Yoshimoto89]

Enzymes inhibited by Mn2+, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: biotin sulfoxide reductase [Del79] , methylmalonyl-CoA mutase [Bobik03] , glutaminase [Brown08] , glutaminase [Brown08] , diacylglycerol pyrophosphate phosphatase [Dillon96] , N-acetylglutamylphosphate reductase [Vogel74] , imidazole glycerol phosphate synthase [Klem93] , phosphoglucomutase [Joshi64] , Rnase [Goedken01] , D-glucarate dehydratase [Comment 3] , D-aminopropanol dehydrogenase [Kelley84, Campbell78]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: Xaa-Pro dipeptidase , 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase , cytidine 3'-phosphate phosphohydrolase , dGMP 5'-phosphate phosphohydrolase , adenosine 3'-phosphate phosphohydrolase , UDP-N-acetylmuramate-alanine ligase , monoacetylchitobiose-6-phosphate hydrolase , 6-phospho-β-D-glucosyl-(1,4)-D-glucose glucohydrolase , phosphoribosylglycinamide formyltransferase , 5'-nucleotidase , 3'-nucleotidase , 8-oxo-dGTP diphosphatase , 2-oxopent-4-enoate hydratase , transketolase , 5-phospho-α-D-ribosyl 1,2-cyclic phosphate phosphodiesterase , 2,3-bisphosphoglycerate-independent phosphoglycerate mutase , RNA ligase , L-ascorbate 6-phosphate lactonase , p-aminobenzoyl-glutamate hydrolase , S-ureidoglycine aminohydrolase , allantoate amidohydrolase , coproporphyrinogen III oxidase , diacylglycerol kinase , tRNA nucleotidyltransferase , fructose-1,6-bisphosphatase , peptidoglycan glycosyltransferase , agmatinase , oligoribonuclease , protein kinase , L-arabinose isomerase , L-fucose isomerase , D-arabinose isomerase , ThDP adenylyl transferase , histidinol dehydrogenase , histidinal dehydrogenase , glutamine synthetase , 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase , 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase , xylose isomerase , 2-deoxyglucose-6-phosphatase , 3-isopropylmalate dehydrogenase , aminopeptidase , examinopeptidase , proline aminopeptidase , deoxyribose 1,5-phosphomutase , adenine deaminase , L-rhamnose isomerase , 1-deoxy-D-xylulose 5-phosphate reductoisomerase , α-D-ribose 1,5-phosphomutase , pyrimidine nucleotidase , guanylate cyclase , glutamine synthetase deadenylase , transketolase , malate dehydrogenase, NAD-requiring , malate dehydrogenase , ribonuclease , 3-octaprenyl-4-hydroxybenzoate carboxy-lyase , RNase T exonuclease , 2-keto-3-deoxygluconokinase , Rnase , phosphoglycerol transferase , phenylhydantoinase , superoxide dismutase , guanosine-3',5'-bis(diphosphate) 3'-diphosphatase , acyl carrier protein phosphodiesterase , NADH pyrophosphatase , phosphoglycerol transferase , isocitrate dehydrogenase , phosphodiesterase, c-di-GMP-specific , RNase , fructose 1,6-bisphosphatase , RNA 3'-terminal phosphate cyclase , α-galactosidase , 3' to 5' proofreading exonuclease

This compound has been characterized as an alternative cofactor or prosthetic group of the following enzymes: glycerate kinase , adenylylsulfate kinase , pantothenate synthetase , NMN adenylyltransferase , cytosine deaminase , methionine adenosyltransferase , geranyl diphosphate synthase , holo-[acyl-carrier-protein] synthase , molybdenum cofactor guanylyltransferase , adenine phosphoribosyltransferase , pyruvate kinase , carbamoyl phosphate synthetase , oxidized nucleoside triphosphate pyrophosphohydrolase , imidazoleglycerol-phosphate dehydratase , 4-diphosphocytidyl-2C-methyl-D-erythritol synthase , NAD+ synthetase, NH3-dependent , pyruvate kinase , aspartate ammonia-lyase , allantoinase , isopentenyl diphosphate isomerase , nucleoside diphosphate kinase , ribose-phosphate diphosphokinase , isocitrate lyase , farnesyl diphosphate synthase , glycerol kinase , hypoxanthine phosphoribosyltransferase , dihydroneopterin triphosphate 2'-epimerase , phosphoenolpyruvate carboxykinase (ATP) , folylpoly-γ-glutamate synthetase , GDP-mannose mannosyl hydrolase

In Growth Media: MOPS medium with 2% glycerol , MOPS medium with 2% glucose , MOPS medium with 0.4% glucose , MOPS medium base , Neidhardt EZ rich defined medium , trace metal solution , LB enriched


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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