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discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
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Escherichia coli K-12 substr. MG1655 Compound: Na+

Synonyms: Sodium, sodium ion

Superclasses: an ion a cation

Component of:
sodium dodecyl sulfate
sodium pyruvate
sodium citrate trihydrate
monosodium phosphate
sodium tetraborate decahydrate
disodium phosphate
sodium tetrahydridoborate
NaF
sodium sulfate
sodium acetate
disodium phosphate heptahydrate
sodium chloride
NhaR-Na+ DNA-binding transcriptional activator (extended summary available)

Chemical Formula: Na

Molecular Weight: 22.99 Daltons

Monoisotopic Molecular Weight: 22.98976967 Daltons

SMILES: [Na+]

InChI: InChI=1S/Na/q+1

InChIKey: InChIKey=FKNQFGJONOIPTF-UHFFFAOYSA-N

Unification Links: CAS:7440-23-5 , ChEBI:29101 , ChemSpider:899 , HMDB:HMDB00588 , IAF1260:37376 , KEGG:C01330 , MetaboLights:MTBLC29101 , PubChem:923

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

Reactions known to produce the compound:

Not in pathways:
sodium dodecyl sulfate + H2O → 1-dodecanol + sulfate + Na+ + H+

In Reactions of unknown directionality:

Not in pathways:
NhaR + Na+ = NhaR-Na+

In Transport reactions:
Na+[periplasmic space] + L-alanine[periplasmic space]Na+[cytosol] + L-alanine[cytosol] ,
Na+[periplasmic space] + L-isoleucine[periplasmic space]Na+[cytosol] + L-isoleucine[cytosol] ,
Na+[periplasmic space] + L-valine[periplasmic space]Na+[cytosol] + L-valine[cytosol] ,
Na+[periplasmic space] + (R)-pantothenate[periplasmic space]Na+[cytosol] + (R)-pantothenate[cytosol] ,
Na+[periplasmic space] + L-proline[periplasmic space]Na+[cytosol] + L-proline[cytosol] ,
Na+[periplasmic space] + L-leucine[periplasmic space]Na+[cytosol] + L-leucine[cytosol] ,
2 Na+[cytosol] + 3 H+[periplasmic space] → 2 Na+[periplasmic space] + 3 H+[cytosol] ,
Na+[periplasmic space] + melibiose[periplasmic space]Na+[cytosol] + melibiose[cytosol] ,
Na+[periplasmic space] + L-serine[periplasmic space]Na+[cytosol] + L-serine[cytosol] ,
2 Na+[periplasmic space] + L-glutamate[periplasmic space] → 2 Na+[cytosol] + L-glutamate[cytosol] ,
Na+[periplasmic space] + 2,3-dioxo-L-gulonate[periplasmic space]Na+[cytosol] + 2,3-dioxo-L-gulonate[cytosol] ,
Na+[cytosol] + 2 H+[periplasmic space]Na+[periplasmic space] + 2 H+[cytosol] ,
a drug[cytosol] + Na+[periplasmic space] → a drug[periplasmic space] + Na+[cytosol] ,
Na+[cytosol] + H+[periplasmic space]Na+[periplasmic space] + H+[cytosol] ,
methyl-β-D-galactoside[periplasmic space] + Na+[periplasmic space] → methyl-β-D-galactoside[cytosol] + Na+[cytosol]

Enzymes activated by Na+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: glyoxylate carboligase [Gupta66, Comment 1]

Enzymes inhibited by Na+, sorted by the type of inhibition, are:

Inhibitor (Noncompetitive) of: ribonuclease [Venkov71]

Inhibitor (Mechanism unknown) of: nitrate reductase [Iobbi87] , guanosine-5'-triphosphate, 3'-diphosphate pyrophosphatase [Keasling93] , trimethylamine N-oxide reductase [Shimokawa79, Silvestro88] , tryptophanase [HogbergRaibaud75, Comment 2] , aspartate semialdehyde dehydrogenase [Helmward89, Hegeman70] , dihydrofolate reductase [Baccanari75, Comment 3] , dTMP kinase [Helmward89]

In Growth Media: PMA carbon source test + N-acetylneuraminate , PMA carbon source test + D-mannose , PMA carbon source test + D-fructose , MOPS medium with 2% glycerol , LB Lennox , MOPS medium with 2% glucose , MOPS medium with 0.4% glucose , MOPS medium base , Neidhardt EZ rich defined medium , PMA carbon source test + putrescine , trace metal solution , PMA sulfur source test + 3-sulfinoalanine , PMA nitrogen source test + L-2-aminopentanoate , PMA carbon source test + citramalate , AB medium with 0.4% acetate , AB medium with 0.2% glucose , M9 medium with 2% glycerol , M9 medium with 1% glycerol , M9 medium with 0.4% glucose , LB enriched , PMA carbon source test + methyl-β -D-glucoside , M9 medium base , PMA carbon source test + 3-hydroxybutanoate , PMA carbon source test + 2-hydroxybutyrate , PMA carbon source test + Tween 80 , PMA carbon source test + Tween 40 , PMA carbon source test + Tween 20 , PMA carbon source test + trans-4-hydroxy-L-proline , PMA carbon source test + gelatin , PMA carbon source test + L-galactono-1,4-lactone , PMA carbon source test + α-hydroxyglutarate-γ-lactone , PMA nitrogen source test + N-acetyl-D,L-glutamate , PMA carbon source test + melezitose , PMA carbon source test + D-ribono-1,4-lactone , PMA carbon source test + salicylate , PMA carbon source test + methyl-α-D-galactopyranoside , PMA nitrogen source test + D-mannosamine , PMA nitrogen source test + ala-gln , PMA nitrogen source test + ala-asp , PMA nitrogen source test + D,L-lactamide , PMA carbon source test + methyl D-lactate , PMA carbon source test + bromosuccinate , PMA carbon source test + gly-asp , PMA nitrogen source test + ala-his , PMA nitrogen source test + L-Ala-L-Glu , PMA nitrogen source test + ala-thr , PMA nitrogen source test + ala-leu , PMA carbon source test + turanose , PMA carbon source test + ala-gly , PMA nitrogen source test + gln , PMA nitrogen source test + gly-asn , PMA carbon source test + diacetyl , PMA carbon source test + lactitol , PMA nitrogen source test + methionine-alanine dipeptide , PMA nitrogen source test + gly-met , PMA sulfur source test + gly-met , PMA sulfur source test + cysteinylglycine , PMA phosphorus source test + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate , PMA phosphorus source test + 3-phospho-D-glycerate , PMA phosphorus source test + 2-phospho-D-glycerate , PMA phosphorus source test + cyclic-AMP , PMA phosphorus source test + 3'-adenosine monophosphate , PMA phosphorus source test + phosphinate , PMA sulfur source test + 4-aminobenzenesulfonate , PMA sulfur source test + ethionine , PMA sulfur source test + sulfolane , PMA sulfur source test + methanesulfonate , PMA sulfur source test + isethionate , PMA sulfur source test + 1-butanesulfonate , PMA sulfur source test + hypotaurine , PMA sulfur source test + taurine , PMA sulfur source test + taurocholate , PMA sulfur source test + lipoamide , PMA sulfur source test + 1-thio-β-D-glucose , PMA sulfur source test + thiourea , PMA sulfur source test + djenkolate , PMA sulfur source test + L-Methionine sulfone , PMA sulfur source test + L-methionine S-oxide , PMA sulfur source test + N-acetyl-DL-methionine , PMA sulfur source test + D-methionine , PMA sulfur source test + met , PMA sulfur source test + glutathione , PMA sulfur source test + lanthionine , PMA sulfur source test + L-cystathionine , PMA sulfur source test + S-methyl-L-cysteine , PMA sulfur source test + N-acetyl-L-cysteine , PMA sulfur source test + cysteamine , PMA sulfur source test + (R)-cysteate , PMA sulfur source test + D-cysteine , PMA sulfur source test + cys , PMA sulfur source test + dithiophosphate , PMA sulfur source test + thiophosphate , PMA sulfur source test + tetrathionate , PMA sulfur source test + thiosulfate , PMA sulfur source test + sulfate , PMA phosphorus source test + thymidine 3'5'-cyclic monophosphate , PMA phosphorus source test + dTMP , PMA phosphorus source test + thymidine 3'-monophosphate , PMA phosphorus source test + methylenediphosphonate , PMA phosphorus source test + 2-aminoethylphosphonate , PMA phosphorus source test + phosphonoacetate , PMA phosphorus source test + phosphoryl-ethanolamine , PMA phosphorus source test + phosphoryl-choline , PMA phosphorus source test + creatine-phosphate , PMA phosphorus source test + O-phospho-L-tyrosine , PMA phosphorus source test + O-phospho-D-tyrosine , PMA phosphorus source test + uridine 3'5'-cyclic monophosphate , PMA phosphorus source test + uridine 2'3'-cyclic monophosphate , PMA phosphorus source test + UMP , PMA phosphorus source test + uridine 3'-monophosphate , PMA phosphorus source test + uridine 2'-monophosphate , PMA phosphorus source test + L-threonine O-3-phosphate , PMA phosphorus source test + 3-phospho-L-serine , PMA phosphorus source test + O-phospho-D-serine , PMA phosphorus source test + N-phospho-L-arginine , PMA phosphorus source test + cysteamine S-phosphate , PMA phosphorus source test + D-mannose 6-phosphate , PMA phosphorus source test + α-D-mannose 1-phosphate , PMA phosphorus source test + 3',5'-cyclic CMP , PMA phosphorus source test + cytidine 2',3'-cyclic monophosphate , PMA phosphorus source test + CMP , PMA phosphorus source test + cytidine-3'-monophosphate , PMA phosphorus source test + cytidine 2'-monophosphate , PMA phosphorus source test + 6-phospho-D-gluconate , PMA phosphorus source test + D-glucosamine-6-phosphate , PMA phosphorus source test + 2-deoxy-D-glucose 6-phosphate , PMA phosphorus source test + D-glucose-6-phosphate , PMA phosphorus source test + α-D-glucose 1-phosphate , PMA phosphorus source test + 2-phosphoglycolate , PMA phosphorus source test + phosphoenolpyruvate , PMA phosphorus source test + cyclic-GMP , PMA phosphorus source test + guanosine 2',3'-cyclic monophosphate , PMA phosphorus source test + GMP , PMA phosphorus source test + guanosine 3'-monophosphate , PMA phosphorus source test + guanosine 2'-monophosphate , PMA phosphorus source test + carbamoyl-phosphate , PMA phosphorus source test + glycerol 2-phosphate , PMA phosphorus source test + sn-glycerol-3-phosphate , PMA phosphorus source test + dithiophosphate , PMA phosphorus source test + thiophosphate , PMA phosphorus source test + adenosine 2'3'-cyclic monophosphate , PMA phosphorus source test + AMP , PMA phosphorus source test + adenosine 2'-monophosphate , PMA phosphorus source test + triethyl phosphate , PMA phosphorus source test + PPPi , PMA phosphorus source test + trimetaphosphate , PMA phosphorus source test + diphosphate , PMA phosphorus source test + phosphate , PMA nitrogen source test + glycyl-L-glutamate , PMA nitrogen source test + ala-gly , PMA nitrogen source test + 5-aminopentanoate , PMA nitrogen source test + 2-aminocaprylate , PMA nitrogen source test + 6-aminohexanoate , PMA nitrogen source test + 4-aminobutyrate , PMA nitrogen source test + 2-aminobutyrate , PMA nitrogen source test + parabanate , PMA nitrogen source test + allantoin , PMA nitrogen source test + alloxan , PMA nitrogen source test + urate , PMA nitrogen source test + xanthosine , PMA nitrogen source test + xanthine , PMA nitrogen source test + inosine , PMA nitrogen source test + uridine , PMA nitrogen source test + uracil , PMA nitrogen source test + thymidine , PMA nitrogen source test + thymine , PMA nitrogen source test + guanosine , PMA nitrogen source test + guanine , PMA nitrogen source test + cytosine , PMA nitrogen source test + cytidine , PMA nitrogen source test + adenosine , PMA nitrogen source test + adenine , PMA nitrogen source test + N-acetyl-D-mannosamine , PMA nitrogen source test + an N-acetyl-D-galactosamine , PMA nitrogen source test + N-acetyl-D-glucosamine , PMA nitrogen source test + galactosamine , PMA nitrogen source test + D-glucosamine , PMA nitrogen source test + glucuronamide , PMA nitrogen source test + formamide , PMA nitrogen source test + acetamide , PMA nitrogen source test + tyramine , PMA nitrogen source test + 2-phenylethylamine , PMA nitrogen source test + histamine , PMA nitrogen source test + agmatine , PMA nitrogen source test + putrescine , PMA nitrogen source test + ethylenediamine , PMA nitrogen source test + ethanolamine , PMA nitrogen source test + ethylamine , PMA nitrogen source test + butylamine , PMA nitrogen source test + n-amylamine , PMA nitrogen source test + methylamine , PMA nitrogen source test + hydroxylamine , PMA nitrogen source test + 5-oxoproline , PMA nitrogen source test + 2-phthalimidoglutarate , PMA nitrogen source test + L-ornithine , PMA nitrogen source test + L-homoserine , PMA nitrogen source test + L-citrulline , PMA nitrogen source test + D-valine , PMA nitrogen source test + D-serine , PMA nitrogen source test + D-lysine , PMA nitrogen source test + D-glutamate , PMA nitrogen source test + D-aspartate , PMA nitrogen source test + D-asparagine , PMA nitrogen source test + D-alanine , PMA nitrogen source test + val , PMA nitrogen source test + tyr , PMA nitrogen source test + trp , PMA nitrogen source test + thr , PMA nitrogen source test + ser , PMA nitrogen source test + pro , PMA nitrogen source test + phe , PMA nitrogen source test + met , PMA nitrogen source test + lys , PMA nitrogen source test + leu , PMA nitrogen source test + ile , PMA nitrogen source test + his , PMA nitrogen source test + gly , PMA nitrogen source test + gln , PMA nitrogen source test + glt , PMA nitrogen source test + cys , PMA nitrogen source test + asp , PMA nitrogen source test + asn , PMA nitrogen source test + arg , PMA nitrogen source test + ala , PMA nitrogen source test + biuret , PMA nitrogen source test + urea , PMA nitrogen source test + nitrate , PMA nitrogen source test + nitrite , PMA nitrogen source test + ammonia , PMA carbon source test + acetoin , PMA carbon source test + (R,R)-2,3-butanediol , PMA carbon source test + dihydroxyacetone , PMA carbon source test + 1-(4-hydroxyphenyl)-2-aminoethanol , PMA carbon source test + sec-butylamine , PMA carbon source test + a D,L-carnitine , PMA carbon source test + val , PMA carbon source test + 5-oxoproline , PMA carbon source test + phe , PMA carbon source test + L-ornithine , PMA carbon source test + met , PMA carbon source test + lys , PMA carbon source test + leu , PMA carbon source test + ile , PMA carbon source test + L-homoserine , PMA carbon source test + his , PMA carbon source test + gly , PMA carbon source test + arg , PMA carbon source test + N-acetyl-L-glutamate , PMA carbon source test + L-alanine amide , PMA carbon source test + acetamide , PMA carbon source test + L-tartrate , PMA carbon source test + D-tartrate , PMA carbon source test + succinamate , PMA carbon source test + sorbate , PMA carbon source test + sebacate , PMA carbon source test + L-quinate , PMA carbon source test + 3-oxalomalate , PMA carbon source test + oxalate , PMA carbon source test + melibionate , PMA carbon source test + malonate , PMA carbon source test + 5-dehydro-D-gluconate , PMA carbon source test + itaconate , PMA carbon source test + 2-ketopentanoate , PMA carbon source test + 4-hydroxybutyrate , PMA carbon source test + 4-hydroxybenzoate , PMA carbon source test + D-glucosamine , PMA carbon source test + citraconate , PMA carbon source test + hexanoate , PMA carbon source test + caprate , PMA carbon source test + 2-butanoate , PMA carbon source test + 5-aminopentanoate , PMA carbon source test + 4-aminobutyrate , PMA carbon source test + N-acetyl -D- glucosaminitol , PMA carbon source test + D-xylitol , PMA carbon source test + D-tagatose , PMA carbon source test + stachyose , PMA carbon source test + L-sorbose , PMA carbon source test + sedoheptulose anhydride , PMA carbon source test + salicin , PMA carbon source test + raffinose , PMA carbon source test + palatinose , PMA carbon source test + 1-O-methyl-β-D-xylopyranose , PMA carbon source test + methyl α-D-mannopyranoside , PMA carbon source test + 1-O-methyl-β-D-glucuronate , PMA carbon source test + 3-O-methyl-d-glucose , PMA carbon source test + methyl-β-D-galactoside , PMA carbon source test + methyl α-D-glucoside , PMA carbon source test + maltitol , PMA carbon source test + L-glucose , PMA carbon source test + β-gentiobiose , PMA carbon source test + 3-O-β-D-galactopyranosyl-D-arabinose , PMA carbon source test + D-fucose , PMA carbon source test + erythritol , PMA carbon source test + 2'-deoxyribose , PMA carbon source test + hydroquinone-O-β-D-glucopyranoside , PMA carbon source test + L-arabitol , PMA carbon source test + D-arabitol , PMA carbon source test + D-arabinose , PMA carbon source test + (R)-amygdalin , PMA carbon source test + D-allose , PMA carbon source test + an N-acetyl-D-galactosamine , PMA carbon source test + a pectin , PMA carbon source test + a mannan , PMA carbon source test + a laminaran , PMA carbon source test + an inulin , PMA carbon source test + glycogen , PMA carbon source test + a dextrin , PMA carbon source test + γ-cyclodextrin , PMA carbon source test + β-cyclodextrin , PMA carbon source test + α-cyclodextrin , PMA carbon source test + chondroitin sulfate C , PMA carbon source test + ethanolamine , PMA carbon source test + 2-phenylethylamine , PMA carbon source test + D-galacturonate , PMA carbon source test + pyruvate , PMA carbon source test + glucuronamide , PMA carbon source test + β-L-lyxopyranose , PMA carbon source test + D-psicose , PMA carbon source test + tyramine , PMA carbon source test + 3-hydroxyphenylacetate , PMA carbon source test + 4-hydroxyphenylacetate , PMA carbon source test + glycylproline , PMA carbon source test + (S)-malate , PMA carbon source test + (R)-malate , PMA carbon source test + methyl pyruvate , PMA carbon source test + mono-methyl hydrogen succinate , PMA carbon source test + N-acetyl-D-mannosamine , PMA carbon source test + acetoacetate , PMA carbon source test + ala , PMA carbon source test + thr , PMA carbon source test + ser , PMA carbon source test + propane-1,2,3-tricarboxylate , PMA carbon source test + glycyl-L-glutamate , PMA carbon source test + inosine , PMA carbon source test + cellobiose , PMA carbon source test + glyoxylate , PMA carbon source test + glycolate , PMA carbon source test + D-galactarate , PMA carbon source test + propionate , PMA carbon source test + fumarate , PMA carbon source test + D-threonine , PMA carbon source test + myo-inositol , PMA carbon source test + citrate , PMA carbon source test + adenosine , PMA carbon source test + deoxyadenosine , PMA carbon source test + maltotriose , PMA carbon source test + D-ribitol , PMA carbon source test + D-fructose-6-phosphate , PMA carbon source test + α-D-glucose 1-phosphate , PMA carbon source test + meso-tartrate , PMA carbon source test + gln , PMA carbon source test + uridine , PMA carbon source test + sucrose , PMA carbon source test + lactulose , PMA carbon source test + lactose , PMA carbon source test + 2-oxobutanoate , PMA carbon source test + 2-oxoglutarate , PMA carbon source test + L-1,2-propanediol , PMA carbon source test + glucosaminate , PMA carbon source test + D-aspartate , PMA carbon source test + asn , PMA carbon source test + thymidine , PMA carbon source test + melibiose , PMA carbon source test + maltose , PMA carbon source test + α-D-glucose , PMA carbon source test + acetate , PMA carbon source test + L-rhamnose , PMA carbon source test + D-ribose , PMA carbon source test + (RS)-malate , PMA carbon source test + D-galactono-1,4-lactone , PMA carbon source test + D-glucose-6-phosphate , PMA carbon source test + glt , PMA carbon source test + D-mannitol , PMA carbon source test + formate , PMA carbon source test + (S)-lactate , PMA carbon source test + D-xylose , PMA carbon source test + sn-glycerol-3-phosphate , PMA carbon source test + D-gluconate , PMA carbon source test + D-glucuronate , PMA carbon source test + L-fucose , PMA carbon source test + glycerol , PMA carbon source test + D-sorbitol , PMA carbon source test + D-serine , PMA carbon source test + D-galactitol , PMA carbon source test + trehalose , PMA carbon source test + D-alanine , PMA carbon source test + pro , PMA carbon source test + asp , PMA carbon source test + D-galactose , PMA carbon source test + succinate , PMA carbon source test + D-glucarate , PMA carbon source test + N-acetyl-D-glucosamine , PMA carbon source test + L-arabinose , Bochner defined minimal medium without phosphorous , Bochner defined minimal medium without sulfur , Bochner defined minimal medium without nitrogen , Bochner defined minimal medium without carbon , Bochner defined minimal medium , M56 medium , AB medium base

Transcription Units regulated by related protein NhaR-Na+ DNA-binding transcriptional activator (3 total):


References

Baccanari75: Baccanari D, Phillips A, Smith S, Sinski D, Burchall J (1975). "Purification and properties of Escherichia coli dihydrofolate reductase." Biochemistry 1975;14(24);5267-73. PMID: 46

Gupta66: Gupta NK, Vennesland B (1966). "Glyoxylate carboligase of Escherichia coli: some properties of the enzyme." Arch Biochem Biophys 1966;113(2);255-64. PMID: 5328735

Hegeman70: Hegeman G, Cohen G, Morgan R "Aspartic semialdehyde dehydrogenase (Escherichia coli K12)." Methods in Enzymology 1970; 17A:708-713.

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

HogbergRaibaud75: Hogberg-Raibaud A, Raibaud O, Goldberg ME (1975). "Kinetic and equilibrium studies on the activation of Escherichia coli K12 tryptophanase by pyridoxal 5'-phosphate and monovalent cations." J Biol Chem 250(9);3352-8. PMID: 1091651

Iobbi87: Iobbi C, Santini CL, Bonnefoy V, Giordano G (1987). "Biochemical and immunological evidence for a second nitrate reductase in Escherichia coli K12." Eur J Biochem 1987;168(2);451-9. PMID: 3311749

Keasling93: Keasling JD, Bertsch L, Kornberg A (1993). "Guanosine pentaphosphate phosphohydrolase of Escherichia coli is a long-chain exopolyphosphatase." Proc Natl Acad Sci U S A 1993;90(15);7029-33. PMID: 8394006

Shimokawa79: Shimokawa O, Ishimoto M (1979). "Purification and some properties of inducible tertiary amine N-oxide reductase from Escherichia coli." J Biochem (Tokyo) 1979;86(6);1709-17. PMID: 393699

Silvestro88: Silvestro A, Pommier J, Giordano G (1988). "The inducible trimethylamine-N-oxide reductase of Escherichia coli K12: biochemical and immunological studies." Biochim Biophys Acta 1988;954(1);1-13. PMID: 3282544

Snell75: Snell EE (1975). "Tryptophanase: structure, catalytic activities, and mechanism of action." Adv Enzymol Relat Areas Mol Biol 1975;42;287-333. PMID: 236639

Venkov71: Venkov P, Schlessinger D, Longo D (1971). "Inhibition of ribonuclease II of Escherichia coli by sodium ions, adenosine-5'-triphosphate, and transfer ribonucleic acid." J Bacteriol 108(1);601-3. PMID: 4941574


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 26, 2014, BIOCYC14A.