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Escherichia coli K-12 substr. MG1655 Compound: L-tartrate

Synonyms: weinsaeure, (+)-tartrate, tartrate, tartaric acid, (R,R)-tartrate, L-tartaric acid, L(+)-tartaric acid, (2R,3R)-tartaric acid, (2R,3R)-tartrate, L-tartarate, L-threarate

Component of: Dan-L-tartrate DNA-binding transcriptional activator (extended summary available)

Chemical Formula: C4H4O6

Molecular Weight: 148.07 Daltons

Monoisotopic Molecular Weight: 150.0164379252 Daltons

SMILES: C(C(C(C([O-])=O)O)O)([O-])=O

InChI: InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/p-2/t1-,2-/m1/s1

InChIKey: InChIKey=FEWJPZIEWOKRBE-JCYAYHJZSA-L

Unification Links: CAS:87-69-4 , ChEBI:30924 , ChemSpider:106644 , HMDB:HMDB00956 , IAF1260:36331 , KEGG:C00898 , PubChem:119400

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -239.04

Reactions known to both consume and produce the compound:

Not in pathways:
L-tartrate ↔ oxaloacetate + H2O

In Reactions of unknown directionality:

Not in pathways:
L-tartrate + NAD+ = 2-hydroxy-3-oxosuccinate + NADH + H+
Dan + L-tartrate = Dan-L-tartrate DNA-binding transcriptional activator

In Transport reactions:
L-tartrate[periplasmic space] + succinate[cytosol]L-tartrate[cytosol] + succinate[periplasmic space]

Enzymes inhibited by L-tartrate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: 2,3-diketo-L-gulonate reductase [Forouhar04] , pH 2.5 acid phosphatase [Dassa82]

Inhibitor (Mechanism unknown) of: D-glucarate dehydratase [Blumenthal66a]

In Growth Media: PMA carbon source test + L-tartrate

Transcription Units regulated by related protein Dan-L-tartrate DNA-binding transcriptional activator (2 total):


References

Blumenthal66a: Blumenthal H "D-Glucarate Dehydrase." Meth Enz 1966;9:660-665.

Dassa82: Dassa E, Cahu M, Desjoyaux-Cherel B, Boquet PL (1982). "The acid phosphatase with optimum pH of 2.5 of Escherichia coli. Physiological and Biochemical study." J Biol Chem 1982;257(12);6669-76. PMID: 6282821

Forouhar04: Forouhar F, Lee I, Benach J, Kulkarni K, Xiao R, Acton TB, Montelione GT, Tong L (2004). "A novel NAD-binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK)." J Biol Chem 279(13);13148-55. PMID: 14718529


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc13.