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discounted EARLY registration ends Dec 31, 2014
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discounted EARLY registration ends Dec 31, 2014
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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Compound: Zn2+

Synonyms: Zn, Zinc, Zn+2, Zn++, zinc ion, Zn(II)

Superclasses: an ion a cation

Component of:
zinc sulfate heptahydrate
zinc sulfate
NrdR-Zn2+ DNA-binding transcriptional repressor
Zur-Zn2+ DNA-binding transcriptional repressor (extended summary available)
ZntR-Zn2+ transcriptional activator

Chemical Formula: Zn

Molecular Weight: 65.38 Daltons

Monoisotopic Molecular Weight: 63.9291466 Daltons

SMILES: [Zn++]

InChI: InChI=1S/Zn/q+2

InChIKey: InChIKey=PTFCDOFLOPIGGS-UHFFFAOYSA-N

Unification Links: CAS:7440-66-6 , ChEBI:29105 , ChemSpider:29723 , HMDB:HMDB01303 , IAF1260:33614 , KEGG:C00038 , MetaboLights:MTBLC29105 , PubChem:32051

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 0.0

In Reactions of unknown directionality:

Not in pathways:
NrdR + Zn2+ = NrdR-Zn2+ DNA-binding transcriptional repressor
Zur + Zn2+ = Zur transcriptional repressor
ZntR + Zn2+ = ZntR transcriptional activator

In Transport reactions:
Zn2+[periplasmic space] + ATP + H2O → Zn2+[cytosol] + ADP + phosphate + H+ ,
Zn2+[periplasmic space]Zn2+[cytosol] ,
Zn2+[cytosol] + H+[periplasmic space]Zn2+[periplasmic space] + H+[cytosol] ,
Zn2+[cytosol] + ATP + H2O → Zn2+[periplasmic space] + ADP + phosphate + H+

Enzymes activated by Zn2+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: GTPase [BlabyHaas12] , D-mannonate oxidoreductase [Portalier72a] , nonspecific dipeptidase [Schroeder94] , Ap4A synthetase [Plateau82, Charlier87] , Ap3A synthetase [Plateau82]

Enzymes inhibited by Zn2+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: cytosine deaminase [Porter93, Comment 1] , ornithine carbamoyltransferase [Comment 2] , ornithine carbamoyltransferase [Comment 3]

Inhibitor (Allosteric) of: diguanylate cyclase [Zahringer13]

Inhibitor (Mechanism unknown) of: non-heme bacterial ferritin [Treffry98] , pyridine nucleotide transhydrogenase [Cao11] , GTPase [Sydor13] , fumarase A [Xu12] , malate dehydrogenase [Wang11f] , glyoxalase [Subedi11] , adenosylmethionine decarboxylase [Lu07] , guanosine kinase [Mori95] , inosine kinase [Mori95] , L-serine deaminase [Newman80a] , 7-α-hydroxysteroid dehydrogenase [Yoshimoto91] , S-formylglutathione hydrolase [Gonzalez06] , S-formylglutathione hydrolase [Gonzalez06] , glycolate oxidase [Lord72] , imidazoleglycerol-phosphate dehydratase [Brady73] , betaine aldehyde dehydrogenase [Falkenberg90] , methylmalonyl-CoA mutase [Bobik03] , glycolaldehyde dehydrogenase [Baldoma87] , L-1,2-propanediol oxidoreductase [Obradors98, Montella05] , glycolaldehyde reductase [Obradors98] , deoxyribose 1,5-phosphomutase [HammerJespersen70] , 3'-nucleotidase [Anraku64] , glutamate decarboxylase B [Helmward89] , 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Ray80a] , cytochrome bo terminal oxidase [Helmward89, Kita86, Kita84] , glycogen phosphorylase [Chen68, Chen68a] , fructoselysine 3-epimerase [Wiame04] , N-acetylglutamylphosphate reductase [Vogel74a] , adenylosuccinate synthetase [Kang95] , methylglyoxal reductase (NADPH-dependent) [Saikusa87] , acetylornithine deacetylase [Vogel74, JavidMajd00] , D-glucuronate isomerase [Ashwell60] , D-galacturonate isomerase [Ashwell60] , argininosuccinate lyase [Vogel74a] , lysyl-tRNA synthetase [Plateau82, Charlier87] , UDP-3-O-acyl-N-acetylglucosamine deacetylase [Jackman99] , phenylalanyl-tRNA synthetase [Mayaux81] , dipeptidyl carboxypeptidase [Henrich93] , tetrahydrodipicolinate succinylase [Simms84] , amylomaltase [Wiesmeyer60] , polyphosphate kinase [Haeusler92] , adenine phosphoribosyltransferase [Hochstadt78a] , glutamate decarboxylase A [Helmward89] , hypoxanthine phosphoribosyltransferase [Hochstadt78] , N-acetylmuramoyl-L-alanine amidase [vanHeijenoort75] , N-acetylglutamate synthase [Marvil77] , selenide, water dikinase [Veres94, Kim93, Kim94] , fructoselysine 6-phosphate deglycase [Wiame02] , taurine dioxygenase [Eichhorn97] , 2',3'-cyclic nucleotide 2'-phosphodiesterase [Anraku64] , D-aminopropanol dehydrogenase [Kelley84, Campbell78] , α-galactosidase [Burstein71] , D-arabinose 5-phosphate isomerase [Meredith05]

Inhibitor (Other types) of: D-arabinose 5-phosphate isomerase [Lim66, Meredith03, Airoldi10]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: fructose bisphosphate aldolase , L-galactonate oxidoreductase , 3-dehydroquinate synthase , alkaline phosphatase , mannose-6-phosphate isomerase , ribonucleoside-triphosphate reductase , UDP-sugar hydrolase , threonine dehydrogenase , rhamnulose-1-phosphate aldolase , carbonic anhydrase , alkaline phosphatase , 5'-ribonucleotidase , tRNA-guanine transglycosylase , UDP-glucose:α-D-galactose-1-phosphate uridylyltransferase , metallopeptidase , diacylglycerol kinase , allantoinase , aldehyde reductase , D-glucuronate isomerase , L-ribulose 5-phosphate 4-epimerase , anhydro-N-acetylmuramoyl-L-alanine amidase , D-ribulose-phosphate aldolase , L-fuculose-phosphate aldolase , N-acetylglucosamine-6-phosphate deacetylase , tRNA adenosine deaminase , carbonic anhydrase , glyoxalase II , isopentenyl diphosphate isomerase , dihydroorotase , threonyl-tRNA synthetase , cysteinyl-tRNA synthetase , alanyl-tRNA synthetase , aminopeptidase , GTP cyclohydrolase , guanine deaminase , 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent , ATP-dependent zinc metalloendoprotease , isoleucyl-tRNA synthetase , porphobilinogen synthase , acetylornithine deacetylase , methionyl-tRNA synthetase , glutamyl-tRNA synthetase , cobalamin-independent homocysteine transmethylase , methionine synthase , deoxyuridine triphosphatase , acyl carrier protein phosphodiesterase , isoaspartyl dipeptidase , 3-demethylubiquinone-8 3-O-methyltransferase , N-succinyl-L-diaminopimelate desuccinylase , formaldehyde dehydrogenase , 23S rRNA m1G745 methyltransferase , cytidine deaminase , deoxycytidine deaminase

Activates: ZraS[inner membrane] + ATP → ZraS-Phis254[inner membrane] + ADP

In Growth Media: MOPS medium with 2% glycerol , MOPS medium with 2% glucose , MOPS medium with 0.4% glucose , MOPS medium base , Neidhardt EZ rich defined medium , trace metal solution , LB enriched , M56 medium

Transcription Units regulated by related protein NrdR-Zn2+ DNA-binding transcriptional repressor (3 total):

Transcription Units regulated by related protein Zur-Zn2+ DNA-binding transcriptional repressor (4 total):


References

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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