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Escherichia coli K-12 substr. MG1655 Polypeptide: conserved protein



Gene: yicC Accession Numbers: EG11192 (EcoCyc), b3644, ECK3634

Regulation Summary Diagram: ?

Summary:
yicC is one of a network of genes believed to play a role in promoting the stress-induced mutagenesis (SIM) response of E. coli K-12 [Al12].

Citations: [Poulsen]

Gene Citations: [Poulsen89]

Locations: cytosol

Map Position: [3,814,699 -> 3,815,562] (82.22 centisomes)
Length: 864 bp / 287 aa

Molecular Weight of Polypeptide: 33.175 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0011913 , DIP:DIP-12428N , EchoBASE:EB1178 , EcoGene:EG11192 , EcoliWiki:b3644 , Mint:MINT-1230449 , OU-Microarray:b3644 , PortEco:yicC , Pride:P23839 , Protein Model Portal:P23839 , RefSeq:NP_418101 , RegulonDB:EG11192 , String:511145.b3644 , UniProt:P23839

Relationship Links: InterPro:IN-FAMILY:IPR005229 , InterPro:IN-FAMILY:IPR013527 , InterPro:IN-FAMILY:IPR013551 , Pfam:IN-FAMILY:PF03755 , Pfam:IN-FAMILY:PF08340

GO Terms:

Cellular Component: GO:0005829 - cytosol Inferred from experiment Inferred by computational analysis [DiazMejia09, Ishihama08]

Gene Class: ORFs Conserved-ORFs

Essentiality data for yicC knockouts: ?

Growth Medium Growth? T (°C) O2 pH Osm/L Growth Observations
LB Lennox Yes 37 Aerobic 7   Yes [Baba06, Comment 1]
M9 medium with 1% glycerol Yes 37 Aerobic 7.2 0.35 Yes [Joyce06, Comment 2]
MOPS medium with 0.4% glucose Yes 37 Aerobic 7.2 0.22 Yes [Baba06, Comment 1]

Credits:
Last-Curated ? 24-Jul-2007 by Keseler I , SRI International


Sequence Features

Feature Class Location Citations Comment
Sequence-Conflict 148
[Poulsen89, UniProt10a]
Alternate sequence: E → Q; UniProt: (in Ref. 1; CAA32451);
Sequence-Conflict 184 -> 189
[Poulsen89, UniProt10a]
Alternate sequence: RLVAKL → SGREV; UniProt: (in Ref. 1; CAA32451);


Gene Local Context (not to scale): ?

Transcription Unit:

Notes:

History:
Peter D. Karp on Thu Jan 16, 2003:
Predicted gene function revised as a result of E. coli genome reannotation by Serres et al. [Serres01 ].
10/20/97 Gene b3644 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG11192; confirmed by SwissProt match.


References

Al12: Al Mamun AA, Lombardo MJ, Shee C, Lisewski AM, Gonzalez C, Lin D, Nehring RB, Saint-Ruf C, Gibson JL, Frisch RL, Lichtarge O, Hastings PJ, Rosenberg SM (2012). "Identity and function of a large gene network underlying mutagenic repair of DNA breaks." Science 338(6112);1344-8. PMID: 23224554

Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Ishihama08: Ishihama Y, Schmidt T, Rappsilber J, Mann M, Hartl FU, Kerner MJ, Frishman D (2008). "Protein abundance profiling of the Escherichia coli cytosol." BMC Genomics 9;102. PMID: 18304323

Joyce06: Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S (2006). "Experimental and computational assessment of conditionally essential genes in Escherichia coli." J Bacteriol 188(23);8259-71. PMID: 17012394

Poulsen: Poulsen P, Jensen KF (1991). "Three genes preceding pyrE on the Escherichia coli chromosome are essential for survival and normal cell morphology in stationary culture and at high temperature." Res Microbiol 142(2-3);283-8. PMID: 1925027

Poulsen89: Poulsen P, Andersen JT, Jensen KF (1989). "Molecular and mutational analysis of three genes preceding pyrE on the Escherichia coli chromosome." Mol Microbiol 3(3);393-404. PMID: 2664418

Serres01: Serres MH, Gopal S, Nahum LA, Liang P, Gaasterland T, Riley M (2001). "A functional update of the Escherichia coli K-12 genome." Genome Biol 2(9);RESEARCH0035. PMID: 11574054

UniProt10a: UniProt Consortium (2010). "UniProt version 2010-11 released on 2010-11-02 00:00:00." Database.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.