Escherichia coli K-12 substr. MG1655 Polypeptide: putative lipoprotein; predicted DNA-binding transcriptional regulator

Gene: ygeR Accession Numbers: G7484 (EcoCyc), b2865, ECK2861

Regulation Summary Diagram: ?

Regulation summary diagram for ygeR

Loss of ygeR exacerbates the division phenotype of an envC nlpD double null mutant [Uehara09]

Locations: inner membrane

Map Position: [2,997,158 <- 2,997,913] (64.6 centisomes, 233°)
Length: 756 bp / 251 aa

Molecular Weight of Polypeptide: 26.565 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0009407 , DIP:DIP-36034N , EchoBASE:EB2860 , EcoGene:EG13048 , EcoliWiki:b2865 , ModBase:Q46798 , OU-Microarray:b2865 , PortEco:ygeR , Protein Model Portal:Q46798 , RefSeq:NP_417341 , RegulonDB:G7484 , SMR:Q46798 , String:511145.b2865 , UniProt:Q46798

Relationship Links: InterPro:IN-FAMILY:IPR011055 , InterPro:IN-FAMILY:IPR016047 , InterPro:IN-FAMILY:IPR018392 , Pfam:IN-FAMILY:PF01476 , Pfam:IN-FAMILY:PF01551 , Prosite:IN-FAMILY:PS51257 , Smart:IN-FAMILY:SM00257

In Paralogous Gene Group: 542 (2 members)

GO Terms:

Biological Process: GO:0000920 - cell separation after cytokinesis Inferred from experiment [Uehara09]
GO:0001896 - autolysis Inferred from experiment [Uehara09]
Cellular Component: GO:0005886 - plasma membrane Inferred by computational analysis [UniProtGOA11, UniProtGOA11a]
GO:0016020 - membrane Inferred by computational analysis [UniProtGOA11a]

Gene Class: ORFs Conserved-ORFs

Essentiality data for ygeR knockouts: ?

Growth Medium Growth? T (°C) O2 pH Osm/L Growth Observations
LB Lennox Yes 37 Aerobic 7   Yes [Baba06, Comment 1]
M9 medium with 1% glycerol Yes 37 Aerobic 7.2 0.35 Yes [Joyce06, Comment 2]
MOPS medium with 0.4% glucose Yes 37 Aerobic 7.2 0.22 Yes [Baba06, Comment 1]

Sequence Features

Protein sequence of putative lipoprotein; predicted DNA-binding transcriptional regulator with features indicated

Feature Class Location Citations Comment
Signal-Sequence 1 -> 25
UniProt: Non-Experimental Qualifier: potential;
Lipid-Binding-Site 26
UniProt: N-palmitoyl cysteine; Non-Experimental Qualifier: potential;
Chain 26 -> 251
UniProt: Uncharacterized lipoprotein ygeR;
Repeat 42 -> 84
UniProt: LysM.

Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Unit:

Transcription-unit diagram


Peter D. Karp on Wed Jan 18, 2006:
Gene right-end position adjusted based on analysis performed in the 2005 E. coli annotation update [Riley06 ].
Markus Krummenacker on Tue Oct 14, 1997:
Gene object created from Blattner lab Genbank (v. M52) entry.


Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

Joyce06: Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S (2006). "Experimental and computational assessment of conditionally essential genes in Escherichia coli." J Bacteriol 188(23);8259-71. PMID: 17012394

PerezRueda04: Perez-Rueda E, Collado-Vides J, Segovia L (2004). "Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea." Comput Biol Chem 28(5-6);341-50. PMID: 15556475

Riley06: Riley M, Abe T, Arnaud MB, Berlyn MK, Blattner FR, Chaudhuri RR, Glasner JD, Horiuchi T, Keseler IM, Kosuge T, Mori H, Perna NT, Plunkett G, Rudd KE, Serres MH, Thomas GH, Thomson NR, Wishart D, Wanner BL (2006). "Escherichia coli K-12: a cooperatively developed annotation snapshot--2005." Nucleic Acids Res 34(1);1-9. PMID: 16397293

Uehara09: Uehara T, Dinh T, Bernhardt TG (2009). "LytM-domain factors are required for daughter cell separation and rapid ampicillin-induced lysis in Escherichia coli." J Bacteriol 191(16);5094-107. PMID: 19525345

UniProt09: UniProt Consortium (2009). "UniProt version 15.8 released on 2009-10-01 00:00:00." Database.

UniProt10a: UniProt Consortium (2010). "UniProt version 2010-07 released on 2010-06-15 00:00:00." Database.

UniProt14a: UniProt Consortium (2014). "UniProt version 2014-01 released on 2014-01-01 00:00:00." Database.

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries."

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 13, 2015, biocyc13.