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Escherichia coli K-12 substr. MG1655 Polypeptide: ArcB sensory histidine kinase - his717 phosphorylated



Gene: arcB Accession Numbers: EG10062 (EcoCyc), b3210, ECK3200

Synonyms: ArcB-Phis717

Regulation Summary Diagram: ?

Regulation summary diagram for arcB

Alternative forms of ArcB sensory histidine kinase - his717 phosphorylated:
ArcB sensory histidine kinase (extended summary available)
ArcB sensory histidine kinase - asp576 phosphorylated (summary available)
ArcB sensory histidine kinase - his292 phosphorylated (summary available)

Summary:
This is the histidine717 phosphorylated form of ArcB - the sensor histidine kinase of the ArcAB two-component signal transduction system.

Gene Citations: [Aiso03]

Locations: inner membrane

Map Position: [3,348,711 <- 3,351,047] (72.18 centisomes, 260°)
Length: 2337 bp / 778 aa

Molecular Weight: 87.983 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0010537 , CGSC:29063 , EchoBASE:EB0060 , EcoGene:EG10062 , OU-Microarray:b3210 , PortEco:arcB , PR:PRO_000024876 , RegulonDB:EG10062

In Paralogous Gene Group: 121 (40 members) , 122 (29 members)

Reactions known to consume the compound:

ArcAB Two-Component Signal Transduction System, quinone dependent :
ArcA + ArcB-Phis717 → ArcA-Pasp54 + ArcB

Not in pathways:
ArcB-Phis717 + H2O → ArcB + phosphate
regulator of RpoS + ArcB-Phis717 → RssB-P + ArcB

Reactions known to produce the compound:

ArcAB Two-Component Signal Transduction System, quinone dependent :
ArcB-Pasp576[inner membrane]ArcB-Phis717[inner membrane]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Biological Process: GO:0000160 - phosphorelay signal transduction system Inferred from experiment [Iuchi92]
Molecular Function: GO:0000155 - phosphorelay sensor kinase activity Inferred from experiment [Iuchi92]
GO:0009927 - histidine phosphotransfer kinase activity Inferred from experiment [Iuchi92]
Cellular Component: GO:0016021 - integral component of membrane Inferred from experiment [Iuchi90]
GO:0005886 - plasma membrane [Iuchi90]

MultiFun Terms: cell structure membrane
information transfer protein related posttranslational modification
metabolism energy metabolism, carbon aerobic respiration
regulation type of regulation posttranscriptional covalent modification, demodification, maturation
regulation type of regulation transcriptional level complex regulation two component regulatory systems (external signal)


Sequence Features

Protein sequence of ArcB sensory histidine kinase - his717 phosphorylated with features indicated

Feature Class Location Common Name Citations State
Phosphorylation-Modification 292 His292 Phosphorylation Site
[Kwon00c, Iuchi93a, Tsuzuki95]
Unmodified
Phosphorylation-Modification 576 Asp576 Phosphorylation Site
[Tsuzuki95]
Unmodified
Phosphorylation-Modification 717 His717 Phosphorylation Site
[Kwon00c, Tsuzuki95]
Modified


Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Unit:

Transcription-unit diagram

Notes:

History:
10/20/97 Gene b3210 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG10062; confirmed by SwissProt match.


References

Aiso03: Aiso T, Ohki R (2003). "Instability of sensory histidine kinase mRNAs in Escherichia coli." Genes Cells 8(2);179-87. PMID: 12581159

Iuchi90: Iuchi S, Matsuda Z, Fujiwara T, Lin EC (1990). "The arcB gene of Escherichia coli encodes a sensor-regulator protein for anaerobic repression of the arc modulon." Mol Microbiol 1990;4(5);715-27. PMID: 2201868

Iuchi92: Iuchi S, Lin EC (1992). "Purification and phosphorylation of the Arc regulatory components of Escherichia coli." J Bacteriol 1992;174(17);5617-23. PMID: 1512197

Iuchi93a: Iuchi S (1993). "Phosphorylation/dephosphorylation of the receiver module at the conserved aspartate residue controls transphosphorylation activity of histidine kinase in sensor protein ArcB of Escherichia coli." J Biol Chem 1993;268(32);23972-80. PMID: 8226939

Kwon00c: Kwon O, Georgellis D, Lin EC (2000). "Phosphorelay as the sole physiological route of signal transmission by the arc two-component system of Escherichia coli." J Bacteriol 182(13);3858-62. PMID: 10851007

Tsuzuki95: Tsuzuki M, Ishige K, Mizuno T (1995). "Phosphotransfer circuitry of the putative multi-signal transducer, ArcB, of Escherichia coli: in vitro studies with mutants." Mol Microbiol 1995;18(5);953-62. PMID: 8825099

Other References Related to Gene Regulation

MendozaVargas09: Mendoza-Vargas A, Olvera L, Olvera M, Grande R, Vega-Alvarado L, Taboada B, Jimenez-Jacinto V, Salgado H, Juarez K, Contreras-Moreira B, Huerta AM, Collado-Vides J, Morett E (2009). "Genome-wide identification of transcription start sites, promoters and transcription factor binding sites in E. coli." PLoS One 4(10);e7526. PMID: 19838305

ShalelLevanon05: Shalel-Levanon S, San KY, Bennett GN (2005). "Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions." Biotechnol Bioeng 92(2):147-59. PMID: 15988767


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Mon Jul 6, 2015, biocyc11.