Subunit composition of trans-2-enoyl-CoA reductase = [subunit of trans-2-enoyl-CoA reductase (NADPH)]2
There is no gene yet identified for this enzyme.
Synonyms: acyl-CoA:NADP+ trans-2-oxidoreductase
EC Number: 18.104.22.168a 2,3,4-saturated fatty acyl CoA + NADP+ ← a trans-2-enoyl-CoA + NADPH + H+
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
The reaction is irreversible in the direction shown.
Alternative Substrates [ Comment 1]:
NADPH-dependent trans-2-enoyl-CoA reductase is distinct from the three other enoyl-CoA reductases in E. coli. The reductase may participate in the chain elongation or degradation of fatty acids. This reaction is similar to the acyl-CoA dehydrogenase reaction, the fadE gene product. There is no gene associated with this enzyme as yet. [Mizugaki82, Nishimaki84]
Mizugaki82: Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H (1982). "Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli." J Biochem (Tokyo) 1982;92(5);1649-54. PMID: 6759504
Nishimaki84: Nishimaki T, Yamanaka H, Mizugaki M (1984). "Studies on the metabolism of unsaturated fatty acids. XIV. Purification and properties of NADPH-dependent trans-2-enoyl-CoA reductase of Escherichia coli K-12." J Biochem (Tokyo) 1984;95(5);1315-21. PMID: 6378898
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