Escherichia coli K-12 substr. MG1655 Enzyme: trans-2-enoyl-CoA reductase

Subunit composition of trans-2-enoyl-CoA reductase = [subunit of trans-2-enoyl-CoA reductase (NADPH)]2

There is no gene yet identified for this enzyme.

Gene-Reaction Schematic

Gene-Reaction Schematic

Enzymatic reaction of: trans-2-enoyl-CoA reductase

Synonyms: acyl-CoA:NADP+ trans-2-oxidoreductase

EC Number:

a 2,3,4-saturated fatty acyl CoA + NADP+ ← a trans-2-enoyl-CoA + NADPH + H+

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

The reaction is irreversible in the direction shown.

Alternative Substrates [ Comment 1]:

NADPH-dependent trans-2-enoyl-CoA reductase is distinct from the three other enoyl-CoA reductases in E. coli. The reductase may participate in the chain elongation or degradation of fatty acids. This reaction is similar to the acyl-CoA dehydrogenase reaction, the fadE gene product. There is no gene associated with this enzyme as yet. [Mizugaki82, Nishimaki84]

Inhibitors (Competitive): NADP+ [Nishimaki84, Comment 2], saturated acyl-CoA [Nishimaki84] Inhibitors (Unknown Mechanism): p-hydroxymercuribenzoate [Nishimaki84], N-ethylmaleimide [Nishimaki84], 5,5'-dithio-bis-2-nitrobenzoate [Nishimaki84]


Mizugaki82: Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H (1982). "Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli." J Biochem (Tokyo) 1982;92(5);1649-54. PMID: 6759504

Nishimaki84: Nishimaki T, Yamanaka H, Mizugaki M (1984). "Studies on the metabolism of unsaturated fatty acids. XIV. Purification and properties of NADPH-dependent trans-2-enoyl-CoA reductase of Escherichia coli K-12." J Biochem (Tokyo) 1984;95(5);1315-21. PMID: 6378898

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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