Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
twitter

Escherichia coli K-12 substr. MG1655 Enzyme: trans-2-enoyl-CoA reductase

Subunit composition of trans-2-enoyl-CoA reductase = [subunit of trans-2-enoyl-CoA reductase (NADPH)]2

Summary:
There is no gene yet identified for this enzyme.

Gene-Reaction Schematic: ?

Gene-Reaction Schematic


Enzymatic reaction of: trans-2-enoyl-CoA reductase

Synonyms: acyl-CoA:NADP+ trans-2-oxidoreductase

EC Number: 1.3.1.38

a 2,3,4-saturated fatty acyl CoA + NADP+ <=> a trans-2-enoyl-CoA + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is irreversible in the direction shown.

Alternative Substrates [Comment 1]:

Summary:
NADPH-dependent trans-2-enoyl-CoA reductase is distinct from the three other enoyl-CoA reductases in E. coli. The reductase may participate in the chain elongation or degradation of fatty acids. This reaction is similar to the acyl-CoA dehydrogenase reaction, the fadE gene product. There is no gene associated with this enzyme as yet. [Mizugaki82, Nishimaki84]

Inhibitors (Competitive): NADP+ [Nishimaki84, Comment 2] , saturated acyl-CoA [Nishimaki84]

Inhibitors (Unknown Mechanism): p-hydroxymercuribenzoate [Nishimaki84] , N-ethylmaleimide [Nishimaki84] , 5,5'-dithio-bis-2-nitrobenzoate [Nishimaki84]


References

Mizugaki82: Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H (1982). "Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli." J Biochem (Tokyo) 1982;92(5);1649-54. PMID: 6759504

Nishimaki84: Nishimaki T, Yamanaka H, Mizugaki M (1984). "Studies on the metabolism of unsaturated fatty acids. XIV. Purification and properties of NADPH-dependent trans-2-enoyl-CoA reductase of Escherichia coli K-12." J Biochem (Tokyo) 1984;95(5);1315-21. PMID: 6378898


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 30, 2015, biocyc13.