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Escherichia coli K-12 substr. MG1655 Polypeptide: membrane ATPase of the MinC-MinD-MinE system that regulates septum placement



Gene: minD Accession Numbers: EG10597 (EcoCyc), b1175, ECK1163

Synonyms: minB

Regulation Summary Diagram: ?

Summary:
MinD recruits MinC to the membrane to form the MinC-MinD complex, which inhibits septum formation, and MinE acts to localize and restrict inhibition to the inappropriate septation sites [deBoer89, Zhao95c, Pichoff95, Raskin97, King99a, Shih02, Hu03c].

MinD exhibits ATPase activity [deBoer91]. MinD ATPase activity is required for the MinC-mediated inhibition pathway [deBoer91], and MinD ATPase activity is positively regulated by MinE and phospholipid [Hu01, Lutkenhaus03]. MinD mediates MinC activity as well as the sensitivity of MinC to MinE localization/regulation [deBoer92]. MinD affects the affinity of MinC for the septal ring [Johnson02a]. MinD is necessary for formation of the MinE ring [Raskin97].

MinC-MinD has been reported to interfere with FtsZ ring assembly [Pichoff01] and with FtsA assembly into the FtsZ ring [Justice00]. The location of the MinC-MinD complex oscillates from pole to pole within the cell; MinE causes complex dissociation that is followed rapidly by complex formation at the opposite pole [Raskin99, Raskin99a, Hu99b, Hale01, Meinhardt01, Howard01, Kruse02, Corbin02, Hu02, Lackner03, Hu03c, Lutkenhaus03, Shih03].

MinD localizes to the inner membrane [deBoer91, Rowland00]. MinD is a peripheral membrane protein that has a phospholipid-interaction motif [Szeto02]. Membrane interaction is discussed in detail [Hu03d, Lackner03, Mileykovskaya03, Zhou03c, Szeto03].

MinD exhibits self-interaction [Szeto01] that is regulated by ATP [Hu03c]. MinD forms ATP-dependent helical structures within phospholipid vesicles, and these structures dissociate upon MinE-stimulated ATP hydrolysis [Hu02, Suefuji02]. Large coiled structures containing MinC, MinD, and MinE are observed in vivo [Shih03]. MinC and MinD interact, and MinE disrupts the interaction between MinC and MinD and the membrane association of the complex [Huang96a, Hu03c, Lutkenhaus03, Lackner03]. The MinC C terminus mediates interaction with MinD [Hu00a]. MinD and MinE interact [Ma03a]. MinD forms dimers in vitro. The binding sites for MinC and MinE are located at the dimer interface and overlap [Wu11].

Mutations in the ATP binding region affect interaction with MinC [Hayashi01b]. Overexpression of minCD causes inviability, and this phenotype is suppressed by overexpression of ftsZ or by certain ftsZ mutations [Bi90]. MinC and MinD exhibit an antagonistic genetic interaction with the SdiA activator of ftsQAZ expression [Wang91]. Overproduction of MinD causes a cell division defect that is suppressed by mutations in MinC [Mulder92].

Mutation of the minB locus causes a minicell phenotype [Davie84, deBoer88a]. Mutation of the minB locus leads to septation at polar and non-polar sites [Jaffe88, Yu99a], disturbances in the cell cycle [Akerlund92], a DNA supercoiling defect [Mulder90], and defects in DNA segregation [Jaffe88, Mulder90, Akerlund92]. Overexpression of the minB locus causes a minicell phenotype [deBoer88a] and a DNA supercoiling defect [Mulder90].

MinD has similarity to the ParA family of ATPases [MotallebiVeshar90]. MinD has similarity to E. coli CobB and CobQ [Galperin00].

Regulation has been described [deBoer88a]. The minB locus includes the minC, minD, and minE genes [deBoer89].

MinD: "minicells"

Reviews: [Niki00, Sullivan00, Margolin00, RayChaudhuri00, Margolin01, Rothfield01, Bignell01, Autret01, Margolin01a, Lutkenhaus02, Gitai03]

Citations: [deBoer90, Labie90, Bi93, Dassain94, Jaffe97, Pichoff97, Gullbrand00, Fu01, Roos01, Yu01b, Akerlund02, Howard03, Schaumberg83, Jaffe90, Mulder91, Akerlund93, Bonny13]

Gene Citations: [deBoer90]

Locations: cytosol, inner membrane

Map Position: [1,223,772 <- 1,224,584] (26.38 centisomes)
Length: 813 bp / 270 aa

Molecular Weight of Polypeptide: 29.614 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0003938 , CGSC:31326 , DIP:DIP-35946N , EchoBASE:EB0592 , EcoGene:EG10597 , EcoliWiki:b1175 , OU-Microarray:b1175 , PortEco:minD , PR:PRO_000023238 , Pride:P0AEZ3 , Protein Model Portal:P0AEZ3 , RefSeq:NP_415693 , RegulonDB:EG10597 , SMR:P0AEZ3 , String:511145.b1175 , UniProt:P0AEZ3

Relationship Links: InterPro:IN-FAMILY:IPR002586 , InterPro:IN-FAMILY:IPR010223 , InterPro:IN-FAMILY:IPR025501 , InterPro:IN-FAMILY:IPR027417 , Panther:IN-FAMILY:PTHR13696:SF1 , PDB:Structure:3Q9L , PDB:Structure:3R9I , PDB:Structure:3R9J , Pfam:IN-FAMILY:PF01656

GO Terms:

Biological Process: GO:0000917 - barrier septum assembly Inferred by computational analysis [UniProtGOA11]
GO:0000918 - barrier septum site selection Inferred by computational analysis [GOA01]
GO:0006200 - ATP catabolic process Inferred by computational analysis [GOA01]
GO:0007049 - cell cycle Inferred by computational analysis [UniProtGOA11]
GO:0051301 - cell division Inferred by computational analysis [UniProtGOA11]
Molecular Function: GO:0005515 - protein binding Inferred from experiment [Rajagopala14, Shen09a, Park11a]
GO:0005524 - ATP binding Inferred from experiment Inferred by computational analysis [UniProtGOA11, deBoer91]
GO:0016887 - ATPase activity Inferred from experiment Inferred by computational analysis [GOA01, deBoer91]
GO:0000166 - nucleotide binding Inferred by computational analysis [UniProtGOA11]
Cellular Component: GO:0005829 - cytosol Inferred from experiment Inferred by computational analysis [DiazMejia09, Ishihama08, LopezCampistrou05]
GO:0005886 - plasma membrane Inferred from experiment Inferred by computational analysis [UniProtGOA11a, UniProtGOA11, deBoer91]
GO:0016020 - membrane Inferred by computational analysis [UniProtGOA11]

MultiFun Terms: cell processes cell cycle physiology
cell processes cell division
cell structure membrane
regulation

Essentiality data for minD knockouts: ?

Growth Medium Growth? T (°C) O2 pH Osm/L Growth Observations
LB Lennox No 37 Aerobic 7   No [Baba06, Comment 1]

Sequence Features

Feature Class Location Citations Comment
Cleavage-of-Initial-Methionine 1
[Link97, UniProt11]
UniProt: Removed.
Chain 2 -> 270
[UniProt09]
UniProt: Septum site-determining protein minD;
Nucleotide-Phosphate-Binding-Region 10 -> 17
[UniProt10]
UniProt: ATP; Non-Experimental Qualifier: potential;
Mutagenesis-Variant 15
[UniProt10a]
Alternate sequence: G → S; UniProt: Less effective then wild-type;
Mutagenesis-Variant 16
[UniProt10a]
Alternate sequence: K → Q; UniProt: Loss of activity;
Alternate sequence: KT → QR; UniProt: Loss of activity;


Gene Local Context (not to scale): ?

Transcription Unit:

Notes:

History:
10/20/97 Gene b1175 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG10597; confirmed by SwissProt match.


References

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Autret01: Autret S, Errington J (2001). "Dynamic proteins in bacteria." Dev Cell 1(1);10-1. PMID: 11703919

Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

Bi90: Bi E, Lutkenhaus J (1990). "Interaction between the min locus and ftsZ." J Bacteriol 172(10);5610-6. PMID: 2211499

Bi93: Bi E, Lutkenhaus J (1993). "Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring." J Bacteriol 175(4);1118-25. PMID: 8432706

Bignell01: Bignell C, Thomas CM (2001). "The bacterial ParA-ParB partitioning proteins." J Biotechnol 91(1);1-34. PMID: 11522360

Bonny13: Bonny M, Fischer-Friedrich E, Loose M, Schwille P, Kruse K (2013). "Membrane Binding of MinE Allows for a Comprehensive Description of Min-Protein Pattern Formation." PLoS Comput Biol 9(12);e1003347. PMID: 24339757

Corbin02: Corbin BD, Yu XC, Margolin W (2002). "Exploring intracellular space: function of the Min system in round-shaped Escherichia coli." EMBO J 21(8);1998-2008. PMID: 11953319

Dassain94: Dassain M, Bouche JP (1994). "The min locus, which confers topological specificity to cell division, is not involved in its coupling with nucleoid separation." J Bacteriol 176(19);6143-5. PMID: 7928979

Davie84: Davie E, Sydnor K, Rothfield LI (1984). "Genetic basis of minicell formation in Escherichia coli K-12." J Bacteriol 158(3);1202-3. PMID: 6327636

deBoer88a: de Boer PA, Crossley RE, Rothfield LI (1988). "Isolation and properties of minB, a complex genetic locus involved in correct placement of the division site in Escherichia coli." J Bacteriol 170(5);2106-12. PMID: 2834323

deBoer89: de Boer PA, Crossley RE, Rothfield LI (1989). "A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli." Cell 56(4);641-9. PMID: 2645057

deBoer90: de Boer PA, Crossley RE, Rothfield LI (1990). "Central role for the Escherichia coli minC gene product in two different cell division-inhibition systems." Proc Natl Acad Sci U S A 1990;87(3);1129-33. PMID: 2137246

deBoer91: de Boer PA, Crossley RE, Hand AR, Rothfield LI (1991). "The MinD protein is a membrane ATPase required for the correct placement of the Escherichia coli division site." EMBO J 10(13);4371-80. PMID: 1836760

deBoer92: de Boer PA, Crossley RE, Rothfield LI (1992). "Roles of MinC and MinD in the site-specific septation block mediated by the MinCDE system of Escherichia coli." J Bacteriol 174(1);63-70. PMID: 1729224

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Hale01: Hale CA, Meinhardt H, de Boer PA (2001). "Dynamic localization cycle of the cell division regulator MinE in Escherichia coli." EMBO J 20(7);1563-72. PMID: 11285221

Hayashi01b: Hayashi I, Oyama T, Morikawa K (2001). "Structural and functional studies of MinD ATPase: implications for the molecular recognition of the bacterial cell division apparatus." EMBO J 20(8);1819-28. PMID: 11296216

Howard01: Howard M, Rutenberg AD, de Vet S (2001). "Dynamic compartmentalization of bacteria: accurate division in E. coli." Phys Rev Lett 87(27 Pt 1);278102. PMID: 11800919

Howard03: Howard M, Rutenberg AD (2003). "Pattern formation inside bacteria: fluctuations due to the low copy number of proteins." Phys Rev Lett 90(12);128102. PMID: 12688905

Hu00a: Hu Z, Lutkenhaus J (2000). "Analysis of MinC reveals two independent domains involved in interaction with MinD and FtsZ." J Bacteriol 182(14);3965-71. PMID: 10869074

Hu01: Hu Z, Lutkenhaus J (2001). "Topological regulation of cell division in E. coli. spatiotemporal oscillation of MinD requires stimulation of its ATPase by MinE and phospholipid." Mol Cell 7(6);1337-43. PMID: 11430835

Hu02: Hu Z, Gogol EP, Lutkenhaus J (2002). "Dynamic assembly of MinD on phospholipid vesicles regulated by ATP and MinE." Proc Natl Acad Sci U S A 99(10);6761-6. PMID: 11983867

Hu03c: Hu Z, Saez C, Lutkenhaus J (2003). "Recruitment of MinC, an inhibitor of Z-ring formation, to the membrane in Escherichia coli: role of MinD and MinE." J Bacteriol 185(1);196-203. PMID: 12486056

Hu03d: Hu Z, Lutkenhaus J (2003). "A conserved sequence at the C-terminus of MinD is required for binding to the membrane and targeting MinC to the septum." Mol Microbiol 47(2);345-55. PMID: 12519187

Hu99b: Hu Z, Lutkenhaus J (1999). "Topological regulation of cell division in Escherichia coli involves rapid pole to pole oscillation of the division inhibitor MinC under the control of MinD and MinE." Mol Microbiol 34(1);82-90. PMID: 10540287

Huang96a: Huang J, Cao C, Lutkenhaus J (1996). "Interaction between FtsZ and inhibitors of cell division." J Bacteriol 178(17);5080-5. PMID: 8752322

Ishihama08: Ishihama Y, Schmidt T, Rappsilber J, Mann M, Hartl FU, Kerner MJ, Frishman D (2008). "Protein abundance profiling of the Escherichia coli cytosol." BMC Genomics 9;102. PMID: 18304323

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Jaffe90: Jaffe A, Boye E, D'Ari R (1990). "Rule governing the division pattern in Escherichia coli minB and wild-type filaments." J Bacteriol 172(6);3500-2. PMID: 2188963

Jaffe97: Jaffe A, Vinella D, D'Ari R (1997). "The Escherichia coli histone-like protein HU affects DNA initiation, chromosome partitioning via MukB, and cell division via MinCDE." J Bacteriol 179(11);3494-9. PMID: 9171392

Johnson02a: Johnson JE, Lackner LL, de Boer PA (2002). "Targeting of (D)MinC/MinD and (D)MinC/DicB complexes to septal rings in Escherichia coli suggests a multistep mechanism for MinC-mediated destruction of nascent FtsZ rings." J Bacteriol 184(11);2951-62. PMID: 12003935

Justice00: Justice SS, Garcia-Lara J, Rothfield LI (2000). "Cell division inhibitors SulA and MinC/MinD block septum formation at different steps in the assembly of the Escherichia coli division machinery." Mol Microbiol 37(2);410-23. PMID: 10931335

King99a: King GF, Rowland SL, Pan B, Mackay JP, Mullen GP, Rothfield LI (1999). "The dimerization and topological specificity functions of MinE reside in a structurally autonomous C-terminal domain." Mol Microbiol 31(4);1161-9. PMID: 10096083

Kruse02: Kruse K (2002). "A dynamic model for determining the middle of Escherichia coli." Biophys J 82(2);618-27. PMID: 11806906

Labie90: Labie C, Bouche F, Bouche JP (1990). "Minicell-forming mutants of Escherichia coli: suppression of both DicB- and MinD-dependent division inhibition by inactivation of the minC gene product." J Bacteriol 172(10);5852-5. PMID: 2211516

Lackner03: Lackner LL, Raskin DM, de Boer PA (2003). "ATP-dependent interactions between Escherichia coli Min proteins and the phospholipid membrane in vitro." J Bacteriol 185(3);735-49. PMID: 12533449

Link97: Link AJ, Robison K, Church GM (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18(8);1259-313. PMID: 9298646

LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532

Lutkenhaus02: Lutkenhaus J (2002). "Dynamic proteins in bacteria." Curr Opin Microbiol 5(6);548-52. PMID: 12457696

Lutkenhaus03: Lutkenhaus J, Sundaramoorthy M (2003). "MinD and role of the deviant Walker A motif, dimerization and membrane binding in oscillation." Mol Microbiol 48(2);295-303. PMID: 12675792

Ma03a: Ma LY, King G, Rothfield L (2003). "Mapping the MinE site involved in interaction with the MinD division site selection protein of Escherichia coli." J Bacteriol 185(16);4948-55. PMID: 12897015

Margolin00: Margolin W (2000). "Organelle division: Self-assembling GTPase caught in the middle." Curr Biol 10(9);R328-30. PMID: 10801435

Margolin01: Margolin W (2001). "Bacterial cell division: a moving MinE sweeper boggles the MinD." Curr Biol 11(10);R395-8. PMID: 11378404

Margolin01a: Margolin W (2001). "Spatial regulation of cytokinesis in bacteria." Curr Opin Microbiol 4(6);647-52. PMID: 11731315

Meinhardt01: Meinhardt H, de Boer PA (2001). "Pattern formation in Escherichia coli: a model for the pole-to-pole oscillations of Min proteins and the localization of the division site." Proc Natl Acad Sci U S A 98(25);14202-7. PMID: 11734639

Mileykovskaya03: Mileykovskaya E, Fishov I, Fu X, Corbin BD, Margolin W, Dowhan W (2003). "Effects of phospholipid composition on MinD-membrane interactions in vitro and in vivo." J Biol Chem 278(25);22193-8. PMID: 12676941

MotallebiVeshar90: Motallebi-Veshareh M, Rouch DA, Thomas CM (1990). "A family of ATPases involved in active partitioning of diverse bacterial plasmids." Mol Microbiol 4(9);1455-63. PMID: 2149583

Mulder90: Mulder E, El'Bouhali M, Pas E, Woldringh CL (1990). "The Escherichia coli minB mutation resembles gyrB in defective nucleoid segregation and decreased negative supercoiling of plasmids." Mol Gen Genet 221(1);87-93. PMID: 2183010

Mulder91: Mulder E, Woldringh CL (1991). "Autoradiographic analysis of diaminopimelic acid incorporation in filamentous cells of Escherichia coli: repression of peptidoglycan synthesis around the nucleoid." J Bacteriol 173(15);4751-6. PMID: 1856170

Mulder92: Mulder E, Woldringh CL, Tetart F, Bouche JP (1992). "New minC mutations suggest different interactions of the same region of division inhibitor MinC with proteins specific for minD and dicB coinhibition pathways." J Bacteriol 174(1);35-9. PMID: 1729222

Niki00: Niki H, Hiraga S, Moriya S (2000). "[Progressing molecular cell biology in bacteria: chromosome partitioning and cell division]." Tanpakushitsu Kakusan Koso 45(2);153-63. PMID: 10667071

Park11a: Park KT, Wu W, Battaile KP, Lovell S, Holyoak T, Lutkenhaus J (2011). "The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis." Cell 146(3);396-407. PMID: 21816275

Pichoff01: Pichoff S, Lutkenhaus J (2001). "Escherichia coli division inhibitor MinCD blocks septation by preventing Z-ring formation." J Bacteriol 183(22);6630-5. PMID: 11673433

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Pichoff97: Pichoff S, Vollrath B, Bouche JP (1997). "MinCD-independent inhibition of cell division by a protein that fuses MalE to the topological specificity factor MinE." J Bacteriol 179(14);4616-9. PMID: 9226273

Rajagopala14: Rajagopala SV, Sikorski P, Kumar A, Mosca R, Vlasblom J, Arnold R, Franca-Koh J, Pakala SB, Phanse S, Ceol A, Hauser R, Siszler G, Wuchty S, Emili A, Babu M, Aloy P, Pieper R, Uetz P (2014). "The binary protein-protein interaction landscape of Escherichia coli." Nat Biotechnol 32(3);285-90. PMID: 24561554

Raskin97: Raskin DM, de Boer PA (1997). "The MinE ring: an FtsZ-independent cell structure required for selection of the correct division site in E. coli." Cell 91(5);685-94. PMID: 9393861

Raskin99: Raskin DM, de Boer PA (1999). "Rapid pole-to-pole oscillation of a protein required for directing division to the middle of Escherichia coli." Proc Natl Acad Sci U S A 96(9);4971-6. PMID: 10220403

Raskin99a: Raskin DM, de Boer PA (1999). "MinDE-dependent pole-to-pole oscillation of division inhibitor MinC in Escherichia coli." J Bacteriol 181(20);6419-24. PMID: 10515933

RayChaudhuri00: RayChaudhuri D, Gordon GS, Wright A (2000). "How does a bacterium find its middle?." Nat Struct Biol 7(11);997-9. PMID: 11062548

Roos01: Roos M, van Geel AB, Aarsman ME, Veuskens JT, Woldringh CL, Nanninga N (2001). "The replicated ftsQAZ and minB chromosomal regions of Escherichia coli segregate on average in line with nucleoid movement." Mol Microbiol 39(3);633-40. PMID: 11169104

Rothfield01: Rothfield LI, Shih YL, King G (2001). "Polar explorers: membrane proteins that determine division site placement." Cell 106(1);13-6. PMID: 11461697

Rowland00: Rowland SL, Fu X, Sayed MA, Zhang Y, Cook WR, Rothfield LI (2000). "Membrane redistribution of the Escherichia coli MinD protein induced by MinE." J Bacteriol 182(3);613-9. PMID: 10633093

Schaumberg83: Schaumberg TH, Kuempel PL (1983). "Genetic mapping of the minB locus in Escherichia coli K-12." J Bacteriol 153(2);1063-5. PMID: 6296039

Shen09a: Shen B, Lutkenhaus J (2009). "The conserved C-terminal tail of FtsZ is required for the septal localization and division inhibitory activity of MinC(C)/MinD." Mol Microbiol 72(2);410-24. PMID: 19415799

Shih02: Shih YL, Fu X, King GF, Le T, Rothfield L (2002). "Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains." EMBO J 21(13);3347-57. PMID: 12093736

Shih03: Shih YL, Le T, Rothfield L (2003). "Division site selection in Escherichia coli involves dynamic redistribution of Min proteins within coiled structures that extend between the two cell poles." Proc Natl Acad Sci U S A 100(13);7865-70. PMID: 12766229

Suefuji02: Suefuji K, Valluzzi R, RayChaudhuri D (2002). "Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE." Proc Natl Acad Sci U S A 99(26);16776-81. PMID: 12482939

Sullivan00: Sullivan SM, Maddock JR (2000). "Bacterial division: Finding the dividing line." Curr Biol 10(6);R249-52. PMID: 10744970

Szeto01: Szeto J, Ramirez-Arcos S, Raymond C, Hicks LD, Kay CM, Dillon JA (2001). "Gonococcal MinD affects cell division in Neisseria gonorrhoeae and Escherichia coli and exhibits a novel self-interaction." J Bacteriol 183(21);6253-64. PMID: 11591668

Szeto02: Szeto TH, Rowland SL, Rothfield LI, King GF (2002). "Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts." Proc Natl Acad Sci U S A 99(24);15693-8. PMID: 12424340

Szeto03: Szeto TH, Rowland SL, Habrukowich CL, King GF (2003). "The MinD Membrane Targeting Sequence Is a Transplantable Lipid-binding Helix." J Biol Chem 278(41);40050-6. PMID: 12882967

UniProt09: UniProt Consortium (2009). "UniProt version 15.8 released on 2009-10-01 00:00:00." Database.

UniProt10: UniProt Consortium (2010). "UniProt version 2010-07 released on 2010-06-15 00:00:00." Database.

UniProt10a: UniProt Consortium (2010). "UniProt version 2010-11 released on 2010-11-02 00:00:00." Database.

UniProt11: UniProt Consortium (2011). "UniProt version 2011-06 released on 2011-06-30 00:00:00." Database.

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries."

Wang91: Wang XD, de Boer PA, Rothfield LI (1991). "A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli." EMBO J 1991;10(11);3363-72. PMID: 1915297

Wu11: Wu W, Park KT, Holyoak T, Lutkenhaus J (2011). "Determination of the structure of the MinD-ATP complex reveals the orientation of MinD on the membrane and the relative location of the binding sites for MinE and MinC." Mol Microbiol 79(6);1515-28. PMID: 21231967

Yu01b: Yu XC, Sun Q, Margolin W (2001). "FtsZ rings in mukB mutants with or without the Min system." Biochimie 83(1);125-9. PMID: 11254986

Yu99a: Yu XC, Margolin W (1999). "FtsZ ring clusters in min and partition mutants: role of both the Min system and the nucleoid in regulating FtsZ ring localization." Mol Microbiol 32(2);315-26. PMID: 10231488

Zhao95c: Zhao CR, de Boer PA, Rothfield LI (1995). "Proper placement of the Escherichia coli division site requires two functions that are associated with different domains of the MinE protein." Proc Natl Acad Sci U S A 92(10);4313-7. PMID: 7753804

Zhou03c: Zhou H, Lutkenhaus J (2003). "Membrane binding by MinD involves insertion of hydrophobic residues within the C-terminal amphipathic helix into the bilayer." J Bacteriol 185(15);4326-35. PMID: 12867440


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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