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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Escherichia coli K-12 substr. MG1655 Polypeptide: predicted phospho-glucosidase, truncated



Gene: glvG Accession Numbers: EG11708 (EcoCyc), b3681, ECK3673

Synonyms: yidM

Regulation Summary Diagram: ?

Summary:
GlvG has similarity to the N-terminal half of the Fusobacterium mortiferum 6-phospho-α-glucosidase and may thus represent a truncated, inactive form of the enzyme [Thompson95].

Map Position: [3,859,372 <- 3,860,010] (83.18 centisomes)
Length: 639 bp / 212 aa

Molecular Weight of Polypeptide: 23.724 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0012036 , DIP:DIP-9813N , EchoBASE:EB1659 , EcoGene:EG11708 , EcoliWiki:b3681 , ModBase:P31450 , OU-Microarray:b3681 , PortEco:glvG , Protein Model Portal:P31450 , RefSeq:NP_418137 , RegulonDB:EG11708 , SMR:P31450 , Swiss-Model:P31450 , UniProt:P31450

Relationship Links: CAZy:IN-FAMILY:GH4 , InterPro:IN-FAMILY:IPR001088 , InterPro:IN-FAMILY:IPR015955 , InterPro:IN-FAMILY:IPR016040 , InterPro:IN-FAMILY:IPR019802 , Pfam:IN-FAMILY:PF02056 , Prints:IN-FAMILY:PR00732 , Prosite:IN-FAMILY:PS01324

In Paralogous Gene Group: 342 (3 members)

GO Terms:

Biological Process: GO:0005975 - carbohydrate metabolic process Inferred by computational analysis [GOA01]
GO:0055114 - oxidation-reduction process Inferred by computational analysis [GOA01]
Molecular Function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds Inferred by computational analysis [GOA01]
GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred by computational analysis [GOA01]
GO:0046872 - metal ion binding Inferred by computational analysis [UniProtGOA11]

MultiFun Terms: metabolism carbon utilization carbon compounds

Essentiality data for glvG knockouts: ?

Growth Medium Growth? T (°C) O2 pH Osm/L Growth Observations
LB Lennox Yes 37 Aerobic 7   Yes [Baba06, Comment 1]
M9 medium with 1% glycerol Yes 37 Aerobic 7.2 0.35 Yes [Joyce06, Comment 2]
MOPS medium with 0.4% glucose Yes 37 Aerobic 7.2 0.22 Yes [Baba06, Comment 1]

Credits:
Last-Curated ? 06-Jul-2011 by Keseler I , SRI International


Sequence Features

Feature Class Location Citations Comment
Nucleotide-Phosphate-Binding-Region 4 -> 70
[UniProt10a]
UniProt: NAD; Non-Experimental Qualifier: by similarity;
Metal-Binding-Site 169
[UniProt10a]
UniProt: Manganese; Non-Experimental Qualifier: by similarity;
Metal-Binding-Site 200
[UniProt10a]
UniProt: Manganese; Non-Experimental Qualifier: by similarity;


Gene Local Context (not to scale): ?

Transcription Unit:

Notes:

History:
10/20/97 Gene b3681 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG11708; confirmed by SwissProt match.


References

Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

GOA01: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Joyce06: Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S (2006). "Experimental and computational assessment of conditionally essential genes in Escherichia coli." J Bacteriol 188(23);8259-71. PMID: 17012394

Thompson95: Thompson J, Gentry-Weeks CR, Nguyen NY, Folk JE, Robrish SA (1995). "Purification from Fusobacterium mortiferum ATCC 25557 of a 6-phosphoryl-O-alpha-D-glucopyranosyl:6-phosphoglucohydrolase that hydrolyzes maltose 6-phosphate and related phospho-alpha-D-glucosides." J Bacteriol 177(9);2505-12. PMID: 7730284

UniProt10a: UniProt Consortium (2010). "UniProt version 2010-07 released on 2010-06-15 00:00:00." Database.

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC13A.