Escherichia coli K-12 substr. MG1655 RNA: RnpB RNA; catalytic subunit of RNAse P

Gene: rnpB Accession Numbers: EG30069 (EcoCyc), b3123, ECK3111

Superclasses: Misc-RNAs

Regulation Summary Diagram: ?

Regulation summary diagram for rnpB

RnpB RNA and RnpA protein together compose ribonuclease P (RNAse P) [Kole79, Kole81]. RNAse P acts in processing of 4.5S RNA [Bothwell76] and tRNA precursor molecules [Schedl75]. The RnpB RNA subunit alone exhibits catalytic activity toward tRNA precursors, but requires the protein subunit for efficient activity toward an 4.5S RNA precursor substrate [GuerrierTakada83, GuerrierTakada84, PeckMiller91]. The protein subunit stabilizes the global structure of the RNA component, allowing it to exhibit the properties of the holoenzyme complex [Buck05]. RNAse P also exhibits activity toward C4 repressor RNA of bacteriophages P1 and P7, which may indicate a role for RNAse P in lysogeny/lysis regulation [Hartmann95], and toward CI RNA, which is involved in immunity to bacteriophage P4 [Briani02].

Activity of the RNAse P RNA and holoenzyme [Schedl75, Chang75, Bikoff75, Bikoff75a, Sakano75, Kirsebom89, Ilgen76, Burgin90, GuerrierTakada83, GuerrierTakada84, Orellana86, GuerrierTakada86, GuerrierTakada88, Vioque89, Surratt90, PeckMiller91, Kazakov91, Nomura88, Tallsjo93, Hardt95, Kufel94, Hartmann95, Steitz93, Warnecke96, Lazard98, Brannvall98, Hori01, Li02e, Kirsebom92, Mikkelsen99, Warnecke00, Pomeranz00, Busch00, Tanaka01, Eubank02, Kaye02, Persson03] and substrate interaction and specificity [Schmidt76, Bothwell76a, Bothwell76a, Thurlow91, Subbarao84, Shlyapnikov86, Kirsebom89, GuerrierTakada84a, Holm92, Green88a, McClain87, Burkard88, Reilly86, Baer88, Vold88, Burkard88a, GuerrierTakada88, Samuelsson88, GuerrierTakada89, Knap90, Surratt90a, Surratt90, Krupp91, Perreault92, Svard92, Schlegl92, Furdon83, Gurevitz83, Nolan93, Gaur93, Svard93, Kleineidam93, Kirsebom93, GuerrierTakada93, Hardt93, Hardt93a, Westhof94, LaGrandeur94, Oh94, Kirsebom94, Hardt95a, Meinnel95b, Yan94, Tallsjo96, Svard96, Kufel96, Gaur96, Liu96e, Kufel96a, Lazard98, Brannvall98, Park00a, Brannvall02, Brannvall03, Hardt96, Harris97c, Christian98, Heide99, Siew99, Pascual99, Heide01, Heide01a, Hansen01b, Zahler03, Ando03, Ando03a, Tanaka03, Nagai03, Ando03b] have been examined in detail.

RnpB RNA interacts with divalent cation (preferentially Mg2+) cofactor [Kazakov91, Perreault93, Smith93c, Chen97b, Frank97, Kufel98, Brannvall99, Christian00, Brannvall01, Christian02]. The association of RnpB RNA and RnpA protein has been examined [Vioque88, Baer89, Talbot94, Talbot94a, Gopalan97, Gopalan99, Kim00d, Biswas00, Sharkady01, Tsai03]. The enzyme complex exhibits 1:1 stoichiometry of RnpB RNA to RnpA protein [Talbot94].

RNAse P fractionates with the inner membrane [Srivastava91a]. Overproduced RNAse P enzyme is also localized to the inner membrane, whereas overproduced RnpB RNA is localized to the cytoplasm [Miczak91].

RnpB RNA is essential for viability [Waugh90]. Mutations in RnbP RNA and in the RnpA protein subunit of RNAse P exhibit different effects on tRNA precursor processing [Kirsebom88]. Mutations in RnpB RNA have been evaluated with respect to effects on RNAase P activity [Waugh89, GuerrierTakada86a, Shiraishi86, Lawrence86, Lumelsky88, GuerrierTakada89, Baer88, Kirsebom93, Tallsjo93a, Green96c, Hardt96a, Kufel96a, Frank96, Pomeranz99, Rasmussen02a]. Truncation of both termini of RnpB RNA completely disrupts RNAase P activity, whereas limited truncation of either terminus does not [GuerrierTakada86a]. The ts709 mutation encodes substitutions at nucleotide positions 89 and 365, and it results in destabilization of the RNA [Sakamoto83]. Deletion mutant RNAs can complement activity in trans [GuerrierTakada92].

The structure of RnpB RNA has been examined [Haas91, Darr92, Lee89c, Waugh89, Ramamoorthy91, Reed82, Morse93, Kim96h, GuerrierTakada84b, Altman86, Lawrence86, Boehm87, Lipson88, Lumelsky88, Vioque88, Zuckermann89, Zito93, 1, Haas94, Harris94, Kirsebom93, Tallsjo93a, Talbot94, Glemarec96, Zarrinkar96, Westhof94, Ciesiolka94, Westhof96, Easterwood97, Chen98b, Massire98, Leontis98, Heide99, Gopalan99, Pomeranz99a, Pomeranz99, Schmitz00, Kent00, Brannvall01].

The RnpB RNA is subject to post-transcriptional processing [Reed82, Sakamoto83a, Gurevitz83a, Reed83, Lundberg95, Kim96h, Kim97d, Kim99h, Sim02, Sim01, Lee02, Ow02, Ow03].

RnpB RNA has been isolated from many other organisms. A database of RNase P RNAs has been developed [Brown94a].

RNAse P can be directed or engineered to cleave exogenous targets of appropriate structure, and therapeutic applications have been investigated [Carter90, Mans90, Forster90, Kikuchi90, Cole99, Kilani00, Hori00, McKinney01, Ando01, Li92d, Kikuchi92, GuerrierTakada95, Liu95a, Kikuchi95, Potuschak93, Kikuchi93, Li96g, Drainas97, GuerrierTakada97, Schwienhorst98, Trang00, Hori00a, Hsu00, Trang00a, Cole01, Ando02, Trang03, Zou03a, Hori00b, Trang02, RodriguezGarcia01, Trang04].

Regulation has been described [Sakamoto83a, Reed82, Lee89c, Ramamoorthy91, Panagiotidis92, Jung97a, Kim97e, Kim97d, Park02b, Motamedi84, Dong96].

Reviews: [Brown91b, Pace85, Apirion93, Stark95, Kirsebom95, Shiraishi95, Hardt95b, Altman95, Wassarman99, Morl01, Cobaleda01, Raj03].

Citations: [Tanaka03a, Bourdeau01, Kim98a, Kim97f, Komine91, Szymkowiak88, Shiraishi88, Vioque86, Dallmann83, Apirion80a, Baer90]

Map Position: [3,268,238 <- 3,268,614] (70.44 centisomes, 254°)
Length: 377 bp

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Genetic Regulation Schematic: ?

Genetic regulation schematic for rnpB

Unification Links: ASAP:ABE-0010269 , CGSC:266 , EchoBASE:EB4232 , EcoGene:EG30069 , EcoliWiki:b3123 , OU-Microarray:b3123 , PortEco:rnpB , RegulonDB:EG30069

MultiFun Terms: information transfer RNA related RNA degradation
information transfer RNA related RNA modification
metabolism degradation of macromolecules RNA

Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Units:

Transcription-unit diagram

Transcription-unit diagram


10/20/97 Gene b3123 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG30069.


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Baer90: Baer MF, Arnez JG, Guerrier-Takada C, Vioque A, Altman S (1990). "Preparation and characterization of RNase P from Escherichia coli." Methods Enzymol 181;569-82. PMID: 2199767

Bikoff75: Bikoff EK, Gefter ML (1975). "In vitro synthesis of transfer RNA. I. Purification of required components." J Biol Chem 250(16);6240-7. PMID: 1099089

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Biswas00: Biswas R, Ledman DW, Fox RO, Altman S, Gopalan V (2000). "Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using disulfide-linked EDTA-Fe." J Mol Biol 296(1);19-31. PMID: 10656815

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Brannvall03: Brannvall M, Pettersson BM, Kirsebom LA (2003). "Importance of the +73/294 interaction in Escherichia coli RNase P RNA substrate complexes for cleavage and metal ion coordination." J Mol Biol 325(4);697-709. PMID: 12507473

Brannvall98: Brannvall M, Mattsson JG, Svard SG, Kirsebom LA (1998). "RNase P RNA structure and cleavage reflect the primary structure of tRNA genes." J Mol Biol 283(4);771-83. PMID: 9790839

Brannvall99: Brannvall M, Kirsebom LA (1999). "Manganese ions induce miscleavage in the Escherichia coli RNase P RNA-catalyzed reaction." J Mol Biol 292(1);53-63. PMID: 10493856

Briani02: Briani F, Del Vecchio E, Migliorini D, Hajnsdorf E, Regnier P, Ghisotti D, Deho G (2002). "RNase E and polyadenyl polymerase I are involved in maturation of CI RNA, the P4 phage immunity factor." J Mol Biol 318(2);321-31. PMID: 12051840

Brown91b: Brown JW, Pace NR (1991). "Structure and evolution of ribonuclease P RNA." Biochimie 73(6);689-97. PMID: 1722425

Brown94a: Brown JW, Haas ES, Gilbert DG, Pace NR (1994). "The Ribonuclease P database." Nucleic Acids Res 22(17);3660-2. PMID: 7524025

Buck05: Buck AH, Dalby AB, Poole AW, Kazantsev AV, Pace NR (2005). "Protein activation of a ribozyme: the role of bacterial RNase P protein." EMBO J 24(19);3360-8. PMID: 16163391

Burgin90: Burgin AB, Pace NR (1990). "Mapping the active site of ribonuclease P RNA using a substrate containing a photoaffinity agent." EMBO J 9(12);4111-8. PMID: 1701142

Burkard88: Burkard U, Soll D (1988). "The unusually long amino acid acceptor stem of Escherichia coli selenocysteine tRNA results from abnormal cleavage by RNase P." Nucleic Acids Res 16(24);11617-24. PMID: 3062578

Burkard88a: Burkard U, Willis I, Soll D (1988). "Processing of histidine transfer RNA precursors. Abnormal cleavage site for RNase P." J Biol Chem 263(5);2447-51. PMID: 3276688

Busch00: Busch S, Kirsebom LA, Notbohm H, Hartmann RK (2000). "Differential role of the intermolecular base-pairs G292-C(75) and G293-C(74) in the reaction catalyzed by Escherichia coli RNase P RNA." J Mol Biol 299(4);941-51. PMID: 10843849

Carter90: Carter BJ, Vold BS, Hecht SM (1990). "Control of the position of RNase P-mediated transfer RNA precursor processing." J Biol Chem 265(13);7100-3. PMID: 2110159

Chang75: Chang S, Carbon J (1975). "The nucleotide sequence of a precursor to the glycine- and threonine-specific transfer ribonucleic acids of Escherichia coli." J Biol Chem 250(14);5542-55. PMID: 167017

Chen97b: Chen Y, Li X, Gegenheimer P (1997). "Ribonuclease P catalysis requires Mg2+ coordinated to the pro-RP oxygen of the scissile bond." Biochemistry 36(9);2425-38. PMID: 9054547

Chen98b: Chen JL, Nolan JM, Harris ME, Pace NR (1998). "Comparative photocross-linking analysis of the tertiary structures of Escherichia coli and Bacillus subtilis RNase P RNAs." EMBO J 17(5);1515-25. PMID: 9482748

Christian00: Christian EL, Kaye NM, Harris ME (2000). "Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme." RNA 6(4);511-9. PMID: 10786842

Christian02: Christian EL, Kaye NM, Harris ME (2002). "Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA." EMBO J 21(9);2253-62. PMID: 11980722

Christian98: Christian EL, McPheeters DS, Harris ME (1998). "Identification of individual nucleotides in the bacterial ribonuclease P ribozyme adjacent to the pre-tRNA cleavage site by short-range photo-cross-linking." Biochemistry 37(50);17618-28. PMID: 9860878

Ciesiolka94: Ciesiolka J, Hardt WD, Schlegl J, Erdmann VA, Hartmann RK (1994). "Lead-ion-induced cleavage of RNase P RNA." Eur J Biochem 219(1-2);49-56. PMID: 8307015

Cobaleda01: Cobaleda C, Sanchez-Garcia I (2001). "RNase P: from biological function to biotechnological applications." Trends Biotechnol 19(10);406-11. PMID: 11587766

Cole01: Cole KB, Dorit RL (2001). "Protein cofactor-dependent acquisition of novel catalytic activity by the RNase P ribonucleoprotein of E. coli." J Mol Biol 307(5);1181-212. PMID: 11292334

Cole99: Cole KB, Dorit RL (1999). "Acquisition of novel catalytic activity by the M1 RNA ribozyme: the cost of molecular adaptation." J Mol Biol 292(4);931-44. PMID: 10525416

Dallmann83: Dallmann G, Quinn T, Apirion D (1983). "A gene affecting accumulation of the RNA moiety of the processing enzyme RNase P." J Bacteriol 156(2);529-36. PMID: 6195144

Darr92: Darr SC, Zito K, Smith D, Pace NR (1992). "Contributions of phylogenetically variable structural elements to the function of the ribozyme ribonuclease P." Biochemistry 31(2);328-33. PMID: 1370627

Dong96: Dong H, Kirsebom LA, Nilsson L (1996). "Growth rate regulation of 4.5 S RNA and M1 RNA the catalytic subunit of Escherichia coli RNase P." J Mol Biol 261(3);303-8. PMID: 8780771

Drainas97: Drainas D, Krupp G (1997). "Design and preparation of sequence-specific RNase P ribozymes." Methods Mol Biol 74;179-85. PMID: 9204433

Easterwood97: Easterwood TR, Harvey SC (1997). "Ribonuclease P RNA: models of the 15/16 bulge from Escherichia coli and the P15 stem loop of Bacillus subtilis." RNA 3(6);577-85. PMID: 9174093

Eubank02: Eubank TD, Biswas R, Jovanovic M, Litovchick A, Lapidot A, Gopalan V (2002). "Inhibition of bacterial RNase P by aminoglycoside-arginine conjugates." FEBS Lett 511(1-3);107-12. PMID: 11821058

Forster90: Forster AC, Altman S (1990). "External guide sequences for an RNA enzyme." Science 249(4970);783-6. PMID: 1697102

Frank96: Frank DN, Ellington AE, Pace NR (1996). "In vitro selection of RNase P RNA reveals optimized catalytic activity in a highly conserved structural domain." RNA 2(12);1179-88. PMID: 8972768

Frank97: Frank DN, Pace NR (1997). "In vitro selection for altered divalent metal specificity in the RNase P RNA." Proc Natl Acad Sci U S A 94(26);14355-60. PMID: 9405616

Furdon83: Furdon PJ, Guerrier-Takada C, Altman S (1983). "A G43 to U43 mutation in E. coli tRNAtyrsu3+ which affects processing by RNase P." Nucleic Acids Res 11(5);1491-505. PMID: 6298744

Gaur93: Gaur RK, Krupp G (1993). "Modification interference approach to detect ribose moieties important for the optimal activity of a ribozyme." Nucleic Acids Res 21(1);21-6. PMID: 8441616

Gaur96: Gaur RK, Hanne A, Conrad F, Kahle D, Krupp G (1996). "Differences in the interaction of Escherichia coli RNase P RNA with tRNAs containing a short or a long extra arm." RNA 2(7);674-81. PMID: 8756410

Glemarec96: Glemarec C, Kufel J, Foldesi A, Maltseva T, Sandstrom A, Kirsebom LA, Chattopadhyaya J (1996). "The NMR structure of 31mer RNA domain of Escherichia coli RNase P RNA using its non-uniformly deuterium labelled counterpart [the 'NMR-window' concept]." Nucleic Acids Res 24(11);2022-35. PMID: 8668532

Gopalan97: Gopalan V, Baxevanis AD, Landsman D, Altman S (1997). "Analysis of the functional role of conserved residues in the protein subunit of ribonuclease P from Escherichia coli." J Mol Biol 267(4);818-29. PMID: 9135114

Gopalan99: Gopalan V, Kuhne H, Biswas R, Li H, Brudvig GW, Altman S (1999). "Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using electron paramagnetic resonance spectroscopy." Biochemistry 38(6);1705-14. PMID: 10026248

Green88a: Green CJ, Vold BS (1988). "Structural requirements for processing of synthetic tRNAHis precursors by the catalytic RNA component of RNase P." J Biol Chem 263(2);652-7. PMID: 2447080

Green96c: Green CJ, Rivera-Leon R, Vold BS (1996). "The catalytic core of RNase P." Nucleic Acids Res 24(8);1497-503. PMID: 8628683

GuerrierTakada83: Guerrier-Takada C, Gardiner K, Marsh T, Pace N, Altman S (1983). "The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme." Cell 35(3 Pt 2);849-57. PMID: 6197186

GuerrierTakada84: Guerrier-Takada C, Altman S (1984). "Catalytic activity of an RNA molecule prepared by transcription in vitro." Science 223(4633);285-6. PMID: 6199841

GuerrierTakada84a: Guerrier-Takada C, McClain WH, Altman S (1984). "Cleavage of tRNA precursors by the RNA subunit of E. coli ribonuclease P (M1 RNA) is influenced by 3'-proximal CCA in the substrates." Cell 38(1);219-24. PMID: 6380759

GuerrierTakada84b: Guerrier-Takada C, Altman S (1984). "Structure in solution of M1 RNA, the catalytic subunit of ribonuclease P from Escherichia coli." Biochemistry 23(26);6327-34. PMID: 6085007

GuerrierTakada86: Guerrier-Takada C, Haydock K, Allen L, Altman S (1986). "Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli." Biochemistry 25(7);1509-15. PMID: 2423112

GuerrierTakada86a: Guerrier-Takada C, Altman S (1986). "M1 RNA with large terminal deletions retains its catalytic activity." Cell 45(2);177-83. PMID: 2421917

GuerrierTakada88: Guerrier-Takada C, van Belkum A, Pleij CW, Altman S (1988). "Novel reactions of RNAase P with a tRNA-like structure in turnip yellow mosaic virus RNA." Cell 53(2);267-72. PMID: 3359488

GuerrierTakada89: Guerrier-Takada C, Lumelsky N, Altman S (1989). "Specific interactions in RNA enzyme-substrate complexes." Science 246(4937);1578-84. PMID: 2480641

GuerrierTakada92: Guerrier-Takada C, Altman S (1992). "Reconstitution of enzymatic activity from fragments of M1 RNA." Proc Natl Acad Sci U S A 89(4);1266-70. PMID: 1741379

GuerrierTakada93: Guerrier-Takada C, Altman S (1993). "A physical assay for and kinetic analysis of the interactions between M1 RNA and tRNA precursor substrates." Biochemistry 32(28);7152-61. PMID: 7688247

GuerrierTakada95: Guerrier-Takada C, Li Y, Altman S (1995). "Artificial regulation of gene expression in Escherichia coli by RNase P." Proc Natl Acad Sci U S A 92(24);11115-9. PMID: 7479948

GuerrierTakada97: Guerrier-Takada C, Salavati R, Altman S (1997). "Phenotypic conversion of drug-resistant bacteria to drug sensitivity." Proc Natl Acad Sci U S A 94(16);8468-72. PMID: 9238000

Gurevitz83: Gurevitz M, Apirion D (1983). "Interplay among processing and degradative enzymes and a precursor ribonucleic acid in the selective maturation and maintenance of ribonucleic acid molecules." Biochemistry 22(17);4000-5. PMID: 6351914

Gurevitz83a: Gurevitz M, Jain SK, Apirion D (1983). "Identification of a precursor molecular for the RNA moiety of the processing enzyme RNase P." Proc Natl Acad Sci U S A 80(14);4450-4. PMID: 6192433

Haas91: Haas ES, Morse DP, Brown JW, Schmidt FJ, Pace NR (1991). "Long-range structure in ribonuclease P RNA." Science 254(5033);853-6. PMID: 1719634

Haas94: Haas ES, Brown JW, Pitulle C, Pace NR (1994). "Further perspective on the catalytic core and secondary structure of ribonuclease P RNA." Proc Natl Acad Sci U S A 91(7);2527-31. PMID: 7511814

Hansen01b: Hansen A, Pfeiffer T, Zuleeg T, Limmer S, Ciesiolka J, Feltens R, Hartmann RK (2001). "Exploring the minimal substrate requirements for trans-cleavage by RNase P holoenzymes from Escherichia coli and Bacillus subtilis." Mol Microbiol 41(1);131-43. PMID: 11454206

Hardt93: Hardt WD, Schlegl J, Erdmann VA, Hartmann RK (1993). "Gel retardation analysis of E. coli M1 RNA-tRNA complexes." Nucleic Acids Res 21(15);3521-7. PMID: 7688454

Hardt93a: Hardt WD, Schlegl J, Erdmann VA, Hartmann RK (1993). "Role of the D arm and the anticodon arm in tRNA recognition by eubacterial and eukaryotic RNase P enzymes." Biochemistry 32(48);13046-53. PMID: 7694652

Hardt95: Hardt WD, Schlegl J, Erdmann VA, Hartmann RK (1995). "Kinetics and thermodynamics of the RNase P RNA cleavage reaction: analysis of tRNA 3'-end variants." J Mol Biol 247(2);161-72. PMID: 7535857

Hardt95a: Hardt WD, Warnecke JM, Erdmann VA, Hartmann RK (1995). "Rp-phosphorothioate modifications in RNase P RNA that interfere with tRNA binding." EMBO J 14(12);2935-44. PMID: 7540978

Hardt95b: Hardt WD, Warnecke JM, Hartmann RK (1995). "Recent approaches to probe functional groups in ribonuclease P RNA by modification interference." Mol Biol Rep 22(2-3);161-9. PMID: 8901505

Hardt96: Hardt WD, Erdmann VA, Hartmann RK (1996). "Rp-deoxy-phosphorothioate modification interference experiments identify 2'-OH groups in RNase P RNA that are crucial to tRNA binding." RNA 2(12);1189-98. PMID: 8972769

Hardt96a: Hardt WD, Hartmann RK (1996). "Mutational analysis of the joining regions flanking helix P18 in E. coli RNase P RNA." J Mol Biol 259(3);422-33. PMID: 8676378

Harris94: Harris ME, Nolan JM, Malhotra A, Brown JW, Harvey SC, Pace NR (1994). "Use of photoaffinity crosslinking and molecular modeling to analyze the global architecture of ribonuclease P RNA." EMBO J 13(17);3953-63. PMID: 7521297

Harris97c: Harris ME, Kazantsev AV, Chen JL, Pace NR (1997). "Analysis of the tertiary structure of the ribonuclease P ribozyme-substrate complex by site-specific photoaffinity crosslinking." RNA 3(6);561-76. PMID: 9174092

Hartmann95: Hartmann RK, Heinrich J, Schlegl J, Schuster H (1995). "Precursor of C4 antisense RNA of bacteriophages P1 and P7 is a substrate for RNase P of Escherichia coli." Proc Natl Acad Sci U S A 92(13);5822-6. PMID: 7597035

Heide01: Heide C, Busch S, Feltens R, Hartmann RK (2001). "Distinct modes of mature and precursor tRNA binding to Escherichia coli RNase P RNA revealed by NAIM analyses." RNA 7(4);553-64. PMID: 11345434

Heide01a: Heide C, Feltens R, Hartmann RK (2001). "Purine N7 groups that are crucial to the interaction of Escherichia coli rnase P RNA with tRNA." RNA 7(7);958-68. PMID: 11453068

Heide99: Heide C, Pfeiffer T, Nolan JM, Hartmann RK (1999). "Guanosine 2-NH2 groups of Escherichia coli RNase P RNA involved in intramolecular tertiary contacts and direct interactions with tRNA." RNA 5(1);102-16. PMID: 9917070

Holm92: Holm PS, Krupp G (1992). "The acceptor stem in pre-tRNAs determines the cleavage specificity of RNase P." Nucleic Acids Res 20(3);421-3. PMID: 1371348

Hori00: Hori Y, Tanaka T, Kikuchi Y (2000). "The catalytic RNA of RNase P from Escherichia coli cleaves Drosophila 2S ribosomal RNA in vitro: a new type of naturally occurring substrate for the ribozyme." FEBS Lett 472(2-3);187-90. PMID: 10788608

Hori00a: Hori Y, Baba H, Ueda R, Tanaka T, Kikuchi Y (2000). "In vitro hyperprocessing of Drosophila tRNAs by the catalytic RNA of RNase P the cloverleaf structure of tRNA is not always stable?." Eur J Biochem 267(15);4781-8. PMID: 10903512

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Other References Related to Gene Regulation

Chen07a: Chen Z, Lewis KA, Shultzaberger RK, Lyakhov IG, Zheng M, Doan B, Storz G, Schneider TD (2007). "Discovery of Fur binding site clusters in Escherichia coli by information theory models." Nucleic Acids Res 35(20);6762-77. PMID: 17921503

Choi05b: Choi HS, Kim KS, Park JW, Jung YH, Lee Y (2005). "Effects of FIS protein on rnpB transcription in Escherichia coli." Mol Cells 19(2);239-45. PMID: 15879709

Choi08: Choi HS, Park JW, Hong SK, Lee K, Lee Y (2008). "Effects of base changes at the transcription start site on stringent control of rnpB in Escherichia coli." Mol Cells 26(2);212-5. PMID: 18677095

Constantinidou06: Constantinidou C, Hobman JL, Griffiths L, Patel MD, Penn CW, Cole JA, Overton TW (2006). "A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth." J Biol Chem 281(8);4802-15. PMID: 16377617

Huerta03: Huerta AM, Collado-Vides J (2003). "Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals." J Mol Biol 333(2);261-78. PMID: 14529615

Monterrubio00: Monterrubio R, Baldoma L, Obradors N, Aguilar J, Badia J (2000). "A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli." J Bacteriol 2000;182(9);2672-4. PMID: 10762278

Sampaio04: Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO (2004). "Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor." J Biol Chem 279(7);5537-48. PMID: 14645248

WhiteZiegler07: White-Ziegler CA, Malhowski AJ, Young S (2007). "Human body temperature (37degrees C) increases the expression of iron, carbohydrate, and amino acid utilization genes in Escherichia coli K-12." J Bacteriol 189(15);5429-40. PMID: 17526711

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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