|Gene:||ibsC||Accession Numbers: G0-10631 (EcoCyc), b4665, ECK4480|
The small open reading frame IbsC was detected by similarity to the open reading frames encoded on the opposite strand of the sib small RNAs [Fozo08]. It was later found that overexpression of a SibC antisense RNA suppresses cell growth, which can be attributed to the production of the toxic peptide IbsC [Mok09].
Overexpression of IbsC is toxic to the cell by disrupting membrane integrity. Whole-genome gene expression analysis after induction of IsbC expression shows changes in expression of many stress response and membrane proteins [Fozo08].
IbsC: "induction brings stasis" [Fozo08]
|Map Position: [3,054,912 <- 3,054,971] (65.84 centisomes)||Length: 60 bp / 19 aa|
Molecular Weight of Polypeptide: 2.209 kD (from nucleotide sequence)
|Biological Process:||GO:0012501 - programmed cell death [Fozo08]|
|MultiFun Terms:||cell processes|
The database does not contain any information about transcription units for this gene.
Fozo08: Fozo EM, Kawano M, Fontaine F, Kaya Y, Mendieta KS, Jones KL, Ocampo A, Rudd KE, Storz G (2008). "Repression of small toxic protein synthesis by the Sib and OhsC small RNAs." Mol Microbiol 70(5):1076-93. PMID: 18710431
Mok09: Mok WW, Navani NK, Barker C, Sawchyn BL, Gu J, Pathania R, Zhu RD, Brown ED, Li Y (2009). "Identification of a toxic peptide through bidirectional expression of small RNAs." Chembiochem 10(2);238-41. PMID: 19090519
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