|Gene:||rdlD||Accession Numbers: G0-9042 (EcoCyc), b4454, ECK3525|
Superclasses: a regulatory RNA
The LdrD peptide and RdlD antisense regulatory RNA are encoded within one of a set of four Long Direct Repeats (LDRs); RdlD acts as the antitoxin of a Type I toxin-antitoxin pair [Kawano02].
Overproduction of LdrD causes toxicity, manifesting as condensation of the nucleoid and cell death. RdlD RNA is complementary to the upstream region of the ldrD gene, and it acts to regulate LdrD translation. The ldrD mRNA is stable, whereas the RdlD antisense RNA is unstable [Kawano02]. [Gerdes07] proposed the hypothesis that translation of LdrD is regulated by RdlD RNA via regulation of translation of the larger ORF ldrX.
RdlD: "regulator detected in LDR-D" [Kawano02]
|Map Position: [3,698,159 -> 3,698,222] (79.71 centisomes)||Length: 64 bp|
|Molecular Function:||GO:0000499 - base pairing with mRNA
GO:0048027 - mRNA 5'-UTR binding [Kawano02]
|MultiFun Terms:||information transfer → RNA related → antisense RNA|
|regulation → type of regulation → posttranscriptional → antisense RNA|
Ingrid Keseler on Mon Oct 16, 2006:
Gene position corrected based on Riley et al. (2006).
Suzanne Paley on Thu Oct 21, 2004:
Position updated based on U00096.2 release of genome
Kawano02: Kawano M, Oshima T, Kasai H, Mori H (2002). "Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli." Mol Microbiol 45(2);333-49. PMID: 12123448
Kawano05: Kawano M, Reynolds AA, Miranda-Rios J, Storz G (2005). "Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli." Nucleic Acids Res 33(3);1040-50. PMID: 15718303
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