Escherichia coli K-12 substr. MG1655 Pathway: superpathway of arginine and polyamine biosynthesis

Pathway diagram: superpathway of arginine and polyamine biosynthesis

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Genetic Regulation Schematic: ?

Genetic regulation schematic for superpathway of arginine and polyamine biosynthesis

Superclasses: Biosynthesis Amines and Polyamines Biosynthesis

E. coli makes four polyamines, putrescine, spermidine, cadaverine, and aminopropylcadaverine, the syntheses of which are shown both here and in superpathway of polyamine biosynthesis I. In the absence of exogenous arginine, the principal flow to putrescine and hence spermidine is via ornithine decarboxylase. In the presence of exogenous arginine, however, when ornithine biosynthesis is halted by repression and feed-back inhibition, biosynthesis of putrescine occurs in two steps from arginine 1) by arginine decarboxylase (which is located in the periplasm so that the arginine that flows into polyamines never mixes with the intracellular pool of that amino acid) and then 2) by agmatinase which produces urea along with putrescine--the only urea-producing reaction in E. coli.

Review: Charlier, D. and N. Glansdorff (2004) "Biosynthesis of Arginine and Polyamines." EcoSal [ECOSAL]

Subpathways: putrescine biosynthesis I , putrescine biosynthesis III , spermidine biosynthesis I , aminopropylcadaverine biosynthesis , superpathway of polyamine biosynthesis I , L-arginine biosynthesis I (via L-ornithine) , L-ornithine biosynthesis

Last-Curated ? 11-Apr-2011 by Fulcher C , SRI International


ECOSAL: "Escherichia coli and Salmonella: Cellular and Molecular Biology." Online edition.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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