If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
|Superclasses:||Biosynthesis → Amino Acids Biosynthesis → Proteinogenic Amino Acids Biosynthesis → L-threonine Biosynthesis|
Biosynthesis of threonine from homoserine is accomplished in a two-step pathway involving the phosphorylated intermediate O-phospho-L-homoserine.
The final product of this pathway, threonine, serves as a structural constituent of proteins and feeds into the biosynthetic pathway for isoleucine. The enzymes carrying out both steps in this pathway are regulated at the gene level by threonine- and isoleucine-dependent attenuation, as part of attenuation control of an operon that also includes a gene coding for an enzyme in the upstream pathway of homoserine biosynthesis.
Review: Patte, J.-C., Biosynthesis of Threonine and Lysine, Chapter 32 [Neidhardt96]
Neidhardt96: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE "Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition." American Society for Microbiology, Washington, D.C., 1996.
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Farrington93: Farrington GK, Kumar A, Shames SL, Ewaskiewicz JI, Ash DE, Wedler FC (1993). "Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate." Arch Biochem Biophys 307(1);165-74. PMID: 7902068
Kim10a: Kim J, Kershner JP, Novikov Y, Shoemaker RK, Copley SD (2010). "Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis." Mol Syst Biol 6;436. PMID: 21119630
Laber94: Laber B, Gerbling KP, Harde C, Neff KH, Nordhoff E, Pohlenz HD (1994). "Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors." Biochemistry 33(11);3413-23. PMID: 7907888
LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532
Parsot83: Parsot C, Cossart P, Saint-Girons I, Cohen GN (1983). "Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12." Nucleic Acids Res 11(21);7331-45. PMID: 6316258
Shames84: Shames SL, Ash DE, Wedler FC, Villafranca JJ (1984). "Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli." J Biol Chem 1984;259:15331-15339. PMID: 6150934
Theze74: Theze J, Kleidman L, St Girons I (1974). "Homoserine kinase from Escherichia coli K-12: properties, inhibition by L-threonine, and regulation of biosynthesis." J Bacteriol 1974;118(2);577-81. PMID: 4364023
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