If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
|Superclasses:||Generation of Precursor Metabolites and Energy → Pentose Phosphate Pathways|
The pentose phosphate pathway is one of the three essential pathways of central metabolism. It supplies three of E. coli's 13 precursor metabolites (compounds needed for the biosyntheses): D-ribose-5-phosphate, sedoheptulose-7-phosphate, and erythrose-4-phosphate. Regardless of the carbon source upon which E. coli is growing, some carbon must flow through the pentose phosphate pathway to meet the cell's requirements for these metabolites. In addition this pathway is an important source of reducing equivalents in the form of NADPH, which is also needed for biosyntheses. The pathway begins with one intermediate of glycolysis, glucose-6-phosphate, and ends with the formation of two others, fructose-6-phosphate and D-glyceraldehyde-3-phosphate.
For convenience, the pentose phosphate pathway is commonly divided into its preliminary oxidative portion in which glucose-6-phosphate is oxidized to ribulose-5-phosphate, and its subsequent non-oxidative portion, shown here, in which, through a series of transaldolase and transketolase reactions, ribulose-5-phosphate is converted into fructose-6-phosphate and glyceraldehyde-3-phosphate.
Superpathways: pentose phosphate pathway
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Butland05: Butland G, Peregrin-Alvarez JM, Li J, Yang W, Yang X, Canadien V, Starostine A, Richards D, Beattie B, Krogan N, Davey M, Parkinson J, Greenblatt J, Emili A (2005). "Interaction network containing conserved and essential protein complexes in Escherichia coli." Nature 433(7025);531-7. PMID: 15690043
Chandran03: Chandran SS, Yi J, Draths KM, von Daeniken R, Weber W, Frost JW (2003). "Phosphoenolpyruvate availability and the biosynthesis of shikimic acid." Biotechnol Prog 19(3);808-14. PMID: 12790643
David70: David J, Wiesmeyer H (1970). "Regulation of ribose metabolism in Escherichia coli. II. Evidence for two ribose-5-phosphate isomerase activities." Biochim Biophys Acta 208(1);56-67. PMID: 4909663
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Domain07: Domain F, Bina XR, Levy SB (2007). "Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR." Mol Microbiol 66(2);383-94. PMID: 17850260
Essenberg75a: Essenberg MK, Cooper RA (1975). "Two ribose-5-phosphate isomerases from Escherichia coli K-12: partial chacterisation of the enzymes and consideration of their possible physiological roles." Eur J Biochem 1975;55:323-332. PMID: 1104357
Follstad98: Follstad BD, Stephanopoulos G (1998). "Effect of reversible reactions on isotope label redistribution--analysis of the pentose phosphate pathway." Eur J Biochem 252(3);360-71. PMID: 9546650
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