If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
Synonyms: vitamin B6 salvage I
|Superclasses:||Biosynthesis → Cofactors, Prosthetic Groups, Electron Carriers Biosynthesis → Vitamins Biosynthesis → Vitamin B6 Biosynthesis|
Pyridoxal 5'-phosphate (PLP) can be synthesized by a salvage pathway. Pyridoxal, pyroxidine and pyridoxamine are taken up from the environment and utilized.
Pyridoxal 5'-phosphate, a coenzyme for many enzymes that participate in amino acid and glycogen metabolism, can be synthesized de novo and by these salvage pathways from pyridoxal, pyroxidine and pyridoxamine that might be present in the environment.
Variants: pyridoxal 5'-phosphate biosynthesis I
Yang98a: Yang Y, Tsui HC, Man TK, Winkler ME (1998). "Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12." J Bacteriol 1998;180(7);1814-21. PMID: 9537380
Di98: Di Salvo M, Yang E, Zhao G, Winkler ME, Schirch V (1998). "Expression, purification, and characterization of recombinant Escherichia coli pyridoxine 5'-phosphate oxidase." Protein Expr Purif 1998;13(3);349-56. PMID: 9693059
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
diSalvo03: di Salvo ML, Safo MK, Musayev FN, Bossa F, Schirch V (2003). "Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase." Biochim Biophys Acta 1647(1-2);76-82. PMID: 12686112
LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532
Mizote96: Mizote T, Tsuda M, Nakazawa T, Nakayama H (1996). "The thiJ locus and its relation to phosphorylation of hydroxymethylpyrimidine in Escherichia coli." Microbiology 1996;142 ( Pt 10);2969-74. PMID: 8885414
Mizote99: Mizote T, Tsuda M, Smith DD, Nakayama H, Nakazawa T (1999). "Cloning and characterization of the thiD/J gene of Escherichia coli encoding a thiamin-synthesizing bifunctional enzyme, hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase." Microbiology 1999;145 ( Pt 2);495-501. PMID: 10075431
Reddick98: Reddick JJ, Kinsland C, Nicewonger R, Christian T, Downs DM, Winkler ME, Begley TP "Overexpression, purification and characterization of two pyrimidine kinases involved in the biosynthesis of thiamin: 4-amino-5-hydroxymethyl-2-methylpyrimidine kinase and 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase." Tetrahedron 54:15983-15991 (1998).
Safo00: Safo MK, Mathews I, Musayev FN, di Salvo ML, Thiel DJ, Abraham DJ, Schirch V (2000). "X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with FMN at 1.8 A resolution." Structure 8(7);751-62. PMID: 10903950
Safo01: Safo MK, Musayev FN, di Salvo ML, Schirch V (2001). "X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate at 2.0 A resolution." J Mol Biol 310(4);817-26. PMID: 11453690
Safo05: Safo MK, Musayev FN, Schirch V (2005). "Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme." Acta Crystallogr D Biol Crystallogr 61(Pt 5);599-604. PMID: 15858270
Safo06: Safo MK, Musayev FN, di Salvo ML, Hunt S, Claude JB, Schirch V (2006). "Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases." J Bacteriol 188(12);4542-52. PMID: 16740960
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