Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Escherichia coli K-12 substr. MG1655 Pathway: fructose degradation

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Genetic Regulation Schematic: ?

Superclasses: Degradation/Utilization/Assimilation Carbohydrates Degradation Sugars Degradation

Summary:
Fructose can serve as the sole source of carbon for E. coli. It is taken up via the fructose PTS permease, entering the cell in the form of fructose-1-phosphate. 1-phosphofructokinase subsequently phosphorylates the C-6 carbon to form fructose-1,6-bisphosphate, which can enter glycolysis I (from glucose-6P).

Review: [Kornberg01]

Credits:
Created 14-Aug-2007 by Keseler I , SRI International


References

Kornberg01: Kornberg HL (2001). "Routes for fructose utilization by Escherichia coli." J Mol Microbiol Biotechnol 3(3);355-9. PMID: 11361065

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Anderson69b: Anderson RL, Wood WA (1969). "Carbohydrate metabolism in microorganisms." Annu Rev Microbiol 1969;23;539-78. PMID: 4900063

Bork93: Bork P, Sander C, Valencia A (1993). "Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases." Protein Sci 2(1);31-40. PMID: 8382990

BRENDA14: BRENDA team (2014). "Imported from BRENDA version existing on Aug 2014." http://www.brenda-enzymes.org.

Buschmeier85: Buschmeier B, Hengstenberg W, Deutscher J (1985). "Purification and properties of 1-phosphofructokinase from Escherichia coli." FEMS Microbiol Lett 1985;29(3):231-235.

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Ferenci71: Ferenci T, Kornberg HL "Pathway of fructose utilization by Escherichia coli." FEBS Letters 1971;13:127-131. PMID: 11945648

Ferenci73: Ferenci T, Kornberg HL (1973). "The utilization of fructose by Escherichia coli. Properties of a mutant defective in fructose 1-phosphate kinase activity." Biochem J 132(2);341-7. PMID: 4579702

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Orchard90: Orchard LM, Kornberg HL (1990). "Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus." Proc R Soc Lond B Biol Sci 1990;242(1304);87-90. PMID: 1981619

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

VeigadaCunha00: Veiga-da-Cunha M, Hoyoux A, Van Schaftingen E, Houyoux A (2000). "Overexpression and purification of fructose-1-phosphate kinase from Escherichia coli: application to the assay of fructose 1-phosphate." Protein Expr Purif 19(1);48-52. PMID: 10833389


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14A.