If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
|Superclasses:||Degradation/Utilization/Assimilation → Carbohydrates Degradation → Sugars Degradation|
Fructose can serve as the sole source of carbon for E. coli. It is taken up via the fructose PTS permease, entering the cell in the form of fructose-1-phosphate. 1-phosphofructokinase subsequently phosphorylates the C-6 carbon to form fructose-1,6-bisphosphate, which can enter glycolysis I (from glucose-6P).
Bork93: Bork P, Sander C, Valencia A (1993). "Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases." Protein Sci 2(1);31-40. PMID: 8382990
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Ferenci73: Ferenci T, Kornberg HL (1973). "The utilization of fructose by Escherichia coli. Properties of a mutant defective in fructose 1-phosphate kinase activity." Biochem J 132(2);341-7. PMID: 4579702
Orchard90: Orchard LM, Kornberg HL (1990). "Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus." Proc R Soc Lond B Biol Sci 1990;242(1304);87-90. PMID: 1981619
VeigadaCunha00: Veiga-da-Cunha M, Hoyoux A, Van Schaftingen E, Houyoux A (2000). "Overexpression and purification of fructose-1-phosphate kinase from Escherichia coli: application to the assay of fructose 1-phosphate." Protein Expr Purif 19(1);48-52. PMID: 10833389
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