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Escherichia coli K-12 substr. MG1655 Pathway: fructose degradation
Inferred from experiment

Pathway diagram: fructose degradation

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Genetic Regulation Schematic

Genetic regulation schematic for fructose degradation

Superclasses: Degradation/Utilization/AssimilationCarbohydrates DegradationSugars Degradation

Fructose can serve as the sole source of carbon for E. coli. It is taken up via the fructose PTS permease, entering the cell in the form of fructose-1-phosphate. 1-phosphofructokinase subsequently phosphorylates the C-6 carbon to form fructose-1,6-bisphosphate, which can enter glycolysis I (from glucose 6-phosphate).

Review: [Kornberg01]

Created 14-Aug-2007 by Keseler I, SRI International


Kornberg01: Kornberg HL (2001). "Routes for fructose utilization by Escherichia coli." J Mol Microbiol Biotechnol 3(3);355-9. PMID: 11361065

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Anderson69: Anderson RL, Wood WA (1969). "Carbohydrate metabolism in microorganisms." Annu Rev Microbiol 1969;23;539-78. PMID: 4900063

Bork93: Bork P, Sander C, Valencia A (1993). "Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases." Protein Sci 2(1);31-40. PMID: 8382990

BRENDA14: BRENDA team (2014). Imported from BRENDA version existing on Aug 2014.

Buschmeier85: Buschmeier B, Hengstenberg W, Deutscher J (1985). "Purification and properties of 1-phosphofructokinase from Escherichia coli." FEMS Microbiol Lett 1985;29(3):231-235.

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Ferenci71: Ferenci T, Kornberg HL "Pathway of fructose utilization by Escherichia coli." FEBS Letters 1971;13:127-131. PMID: 11945648

Ferenci73: Ferenci T, Kornberg HL (1973). "The utilization of fructose by Escherichia coli. Properties of a mutant defective in fructose 1-phosphate kinase activity." Biochem J 132(2);341-7. PMID: 4579702

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Orchard90: Orchard LM, Kornberg HL (1990). "Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus." Proc R Soc Lond B Biol Sci 1990;242(1304);87-90. PMID: 1981619

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

VeigadaCunha00: Veiga-da-Cunha M, Hoyoux A, Van Schaftingen E, Houyoux A (2000). "Overexpression and purification of fructose-1-phosphate kinase from Escherichia coli: application to the assay of fructose 1-phosphate." Protein Expr Purif 19(1);48-52. PMID: 10833389

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Apr 29, 2016, biocyc11.