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Escherichia coli K-12 substr. MG1655 Pathway: L-lactaldehyde degradation (aerobic)
Inferred from experiment


Pathway diagram: L-lactaldehyde degradation (aerobic)

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Genetic Regulation Schematic

Genetic regulation schematic for L-lactaldehyde degradation (aerobic)

Superclasses: Degradation/Utilization/AssimilationAldehyde DegradationLactaldehyde Degradation

Summary:
L-lactaldehyde is one of two products resulting from degradation of the two methylpentoses L-fucose and rhamnose, which are metabolized by an analogous series of reactions.

Aerobically, lactaldehyde is oxidized in two steps to pyruvate, which enters central metabolism.

Review: Mayer, C. and W. Boos, Hexose/Pentose and Hexitol/Pentitol Metabolism. EcoSal Module 3.4.1 [ECOSAL]

Superpathways: superpathway of methylglyoxal degradation, methylglyoxal degradation IV, superpathway of fucose and rhamnose degradation

Variants: L-lactaldehyde degradation (anaerobic)

Credits:
Created 24-Oct-2007 by Keseler I, SRI International


References

ECOSAL: "Escherichia coli and Salmonella: Cellular and Molecular Biology." Online edition.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Alkim15: Alkim C, Cam Y, Trichez D, Auriol C, Spina L, Vax A, Bartolo F, Besse P, Francois JM, Walther T (2015). "Optimization of ethylene glycol production from (D)-xylose via a synthetic pathway implemented in Escherichia coli." Microb Cell Fact 14;127. PMID: 26336892

Aziz15: Aziz RK, Khaw VL, Monk JM, Brunk E, Lewis R, Loh SI, Mishra A, Nagle AA, Satyanarayana C, Dhakshinamoorthy S, Luche M, Kitchen DB, Andrews KA, Palsson BO, Charusanti P (2015). "Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC." Front Microbiol 6;958. PMID: 26441892

Badia91: Badia J, Gimenez R, Baldoma L, Barnes E, Fessner WD, Aguilar J (1991). "L-lyxose metabolism employs the L-rhamnose pathway in mutant cells of Escherichia coli adapted to grow on L-lyxose." J Bacteriol 1991;173(16);5144-50. PMID: 1650346

Baldoma87: Baldoma L, Aguilar J (1987). "Involvement of lactaldehyde dehydrogenase in several metabolic pathways of Escherichia coli K12." J Biol Chem 262(29);13991-6. PMID: 3308886

Baldoma88: Baldoma L, Aguilar J (1988). "Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation." J Bacteriol 170(1);416-21. PMID: 3275622

Caballero83: Caballero E, Baldoma L, Ros J, Boronat A, Aguilar J (1983). "Identification of lactaldehyde dehydrogenase and glycolaldehyde dehydrogenase as functions of the same protein in Escherichia coli." J Biol Chem 1983;258(12);7788-92. PMID: 6345530

Chen87a: Chen YM, Zhu Y, Lin EC (1987). "NAD-linked aldehyde dehydrogenase for aerobic utilization of L-fucose and L-rhamnose by Escherichia coli." J Bacteriol 1987;169(7);3289-94. PMID: 3298215

Cocks74: Cocks GT, Aguilar T, Lin EC (1974). "Evolution of L-1, 2-propanediol catabolism in Escherichia coli by recruitment of enzymes for L-fucose and L-lactate metabolism." J Bacteriol 118(1);83-8. PMID: 4595205

Di07: Di Costanzo L, Gomez GA, Christianson DW (2007). "Crystal structure of lactaldehyde dehydrogenase from Escherichia coli and inferences regarding substrate and cofactor specificity." J Mol Biol 366(2);481-93. PMID: 17173928

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Dong93b: Dong JM, Taylor JS, Latour DJ, Iuchi S, Lin EC (1993). "Three overlapping lct genes involved in L-lactate utilization by Escherichia coli." J Bacteriol 1993;175(20);6671-8. PMID: 8407843

Eppler02: Eppler T, Postma P, Schutz A, Volker U, Boos W (2002). "Glycerol-3-phosphate-induced catabolite repression in Escherichia coli." J Bacteriol 184(11);3044-52. PMID: 12003946

Ewaschuk05: Ewaschuk JB, Naylor JM, Zello GA (2005). "D-lactate in human and ruminant metabolism." J Nutr 135(7);1619-25. PMID: 15987839

Franchini06: Franchini AG, Egli T (2006). "Global gene expression in Escherichia coli K-12 during short-term and long-term adaptation to glucose-limited continuous culture conditions." Microbiology 152(Pt 7);2111-27. PMID: 16804185

Futai77a: Futai M, Kimura H (1977). "Inducible membrane-bound L-lactate dehydrogenase from Escherichia coli. Purification and properties." J Biol Chem 1977;252(16);5820-7. PMID: 18473

Gaudet10: Gaudet P, Livstone M, Thomas P (2010). "Annotation inferences using phylogenetic trees." PMID: 19578431

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

GOA06: GOA, SIB (2006). "Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins."

Hacking76: Hacking AJ, Lin EC (1976). "Disruption of the fucose pathway as a consequence of genetic adaptation to propanediol as a carbon source in Escherichia coli." J Bacteriol 126(3);1166-72. PMID: 181364

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 20.0 (software by SRI International) on Thu May 5, 2016, BIOCYC13A.