Locations of Mapped Genes:
|Superclasses:||Signal transduction pathways|
In E.coli K-12, QseBC is thought to be a quorum sensing two-component system (TCS) involved in regulation of flagella biogenesis through activation of the flhDC operon - the principal regulator of flagellar biogenesis [Sperandio02]. QseC is the membrane associated sensor kinase; QseB the response regulator. Characterisation of the QseBC TCS has been largely undertaken in enterohaemorrhagic E. coli (EHEC) where it forms part of the signalling cascade that activates expression of virulence genes including those that control flagella expression. qseB and qseC from EHEC and E. coli K-12 are almost identical [Sperandio02].
The E coli K-12 qseBC operon is activated by the AI-2 quorum sensing system but a direct effect of the AI-2 molecule on the phosphorylation status of QseC has not been demonstrated [Sperandio02]. In EHEC autophosphorylation of QseC in response to the auto-inducer AI-3, has been reported [Clarke06] and the response regulator QseB has been shown to bind to the flhDC promoter [Clarke05].
Sperandio02: Sperandio V, Torres AG, Kaper JB (2002). "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli." Mol Microbiol 43(3);809-21. PMID: 11929534
Clarke05a: Clarke MB, Sperandio V (2005). "Transcriptional autoregulation by quorum sensing Escherichia coli regulators B and C (QseBC) in enterohaemorrhagic E. coli (EHEC)." Mol Microbiol 58(2);441-55. PMID: 16194231
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Schaller02: Schaller A, Guo M, Gisanrin O, Zhang Y (2002). "Escherichia coli genes involved in resistance to pyrazinoic acid, the active component of the tuberculosis drug pyrazinamide." FEMS Microbiol Lett 211(2);265-70. PMID: 12076823
Shimada13a: Shimada T, Kori A, Ishihama A (2013). "Involvement of the ribose operon repressor RbsR in regulation of purine nucleotide synthesis in Escherichia coli." FEMS Microbiol Lett 344(2);159-65. PMID: 23651393
Zhou03: Zhou L, Lei XH, Bochner BR, Wanner BL (2003). "Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems." J Bacteriol 185(16);4956-72. PMID: 12897016
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