Escherichia coli K-12 substr. MG1655 Pathway: QseBC Two-Component Signal Transduction System, quorum sensing related

Pathway diagram: QseBC Two-Component Signal Transduction System, quorum sensing related

Diagram Key:

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Genetic Regulation Schematic

Genetic regulation schematic for QseBC Two-Component Signal Transduction System, quorum sensing related

Synonyms: QseBC

Superclasses: Signal transduction pathways

In E.coli K-12, QseBC is thought to be a quorum sensing two-component system (TCS) involved in regulation of flagella biogenesis through activation of the flhDC operon - the principal regulator of flagellar biogenesis [Sperandio02]. QseC is the membrane associated sensor kinase; QseB the response regulator. Characterisation of the QseBC TCS has been largely undertaken in enterohaemorrhagic E. coli (EHEC) where it forms part of the signalling cascade that activates expression of virulence genes including those that control flagella expression. qseB and qseC from EHEC and E. coli K-12 are almost identical [Sperandio02].

The E coli K-12 qseBC operon is activated by the AI-2 quorum sensing system but a direct effect of the AI-2 molecule on the phosphorylation status of QseC has not been demonstrated [Sperandio02]. In EHEC autophosphorylation of QseC in response to the auto-inducer AI-3, has been reported [Clarke06] and the response regulator QseB has been shown to bind to the flhDC promoter [Clarke05].

Created 26-Apr-2010 by Mackie A, Macquarie University


Clarke05: Clarke MB, Sperandio V (2005). "Transcriptional regulation of flhDC by QseBC and sigma (FliA) in enterohaemorrhagic Escherichia coli." Mol Microbiol 57(6);1734-49. PMID: 16135237

Clarke06: Clarke MB, Hughes DT, Zhu C, Boedeker EC, Sperandio V (2006). "The QseC sensor kinase: a bacterial adrenergic receptor." Proc Natl Acad Sci U S A 103(27);10420-5. PMID: 16803956

Sperandio02: Sperandio V, Torres AG, Kaper JB (2002). "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli." Mol Microbiol 43(3);809-21. PMID: 11929534

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Clarke05a: Clarke MB, Sperandio V (2005). "Transcriptional autoregulation by quorum sensing Escherichia coli regulators B and C (QseBC) in enterohaemorrhagic E. coli (EHEC)." Mol Microbiol 58(2);441-55. PMID: 16194231

Daley05: Daley DO, Rapp M, Granseth E, Melen K, Drew D, von Heijne G (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308(5726);1321-3. PMID: 15919996

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Gaudet10: Gaudet P, Livstone M, Thomas P (2010). "Annotation inferences using phylogenetic trees." PMID: 19578431

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Schaller02: Schaller A, Guo M, Gisanrin O, Zhang Y (2002). "Escherichia coli genes involved in resistance to pyrazinoic acid, the active component of the tuberculosis drug pyrazinamide." FEMS Microbiol Lett 211(2);265-70. PMID: 12076823

Shimada13a: Shimada T, Kori A, Ishihama A (2013). "Involvement of the ribose operon repressor RbsR in regulation of purine nucleotide synthesis in Escherichia coli." FEMS Microbiol Lett 344(2);159-65. PMID: 23651393

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries."

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

Zhou03a: Zhou L, Lei XH, Bochner BR, Wanner BL (2003). "Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems." J Bacteriol 185(16);4956-72. PMID: 12897016

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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