Locations of Mapped Genes:
Synonyms: BaeSR, BaeSR system
|Superclasses:||Signal transduction pathways|
In E. coliK-12, two component systems (TCSs) sense and respond to changes in environmental conditions. Typically, a membrane associated sensor kinase autophosphorylates in response to an environmental signal. The sensor kinase then transfers a phosphoryl group to a response regulator (RR) which thus activated, effects a response. The majority of RRs in E. coli are transcription factors.
The BaeS and BaeR proteins are respectively, the sensor kinase and response regulator of the E. coli BaeSR two-component system [Nagasawa93]. The BaeSR TCS induces expression of spy in response to envelope stresses such as spheroblast formation or misfolded pilus subunits, leading to the suggestion that the BaeSR TCS is an envelope stress response pathway [Raffa02, BuryMone09]. baeS and baeR form an operon with the multidrug resistance cluster mdtABCD and BaeR binds to and stimulates the transcriptional activity of the mdtA promoter [Baranova02]. Overexpression of BaeR results in increased resistance to novobiocin and deoxycholate [Baranova02, Nagakubo02] but this phenotype is not dependent on the presence of BaeS [Baranova02].
Baranova02: Baranova N, Nikaido H (2002). "The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate." J Bacteriol 184(15);4168-76. PMID: 12107134
BuryMone09: Bury-Mone S, Nomane Y, Reymond N, Barbet R, Jacquet E, Imbeaud S, Jacq A, Bouloc P (2009). "Global analysis of extracytoplasmic stress signaling in Escherichia coli." PLoS Genet 5(9);e1000651. PMID: 19763168
Nagakubo02: Nagakubo S, Nishino K, Hirata T, Yamaguchi A (2002). "The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC." J Bacteriol 184(15);4161-7. PMID: 12107133
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Hirakawa03: Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A (2003). "Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli." J Antimicrob Chemother 52(4);576-82. PMID: 12951338
Hirakawa03a: Hirakawa H, Nishino K, Hirata T, Yamaguchi A (2003). "Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli." J Bacteriol 185(6);1851-6. PMID: 12618449
Leblanc11: Leblanc SK, Oates CW, Raivio TL (2011). "Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli." J Bacteriol 193(13);3367-75. PMID: 21515766
Nishino05: Nishino K, Honda T, Yamaguchi A (2005). "Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system." J Bacteriol 187(5);1763-72. PMID: 15716448
Rajagopala14: Rajagopala SV, Sikorski P, Kumar A, Mosca R, Vlasblom J, Arnold R, Franca-Koh J, Pakala SB, Phanse S, Ceol A, Hauser R, Siszler G, Wuchty S, Emili A, Babu M, Aloy P, Pieper R, Uetz P (2014). "The binary protein-protein interaction landscape of Escherichia coli." Nat Biotechnol 32(3);285-90. PMID: 24561554
Srivastava14: Srivastava SK, Lambadi PR, Ghosh T, Pathania R, Navani NK (2014). "Genetic regulation of spy gene expression in Escherichia coli in the presence of protein unfolding agent ethanol." Gene 548(1);142-8. PMID: 24999585
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