Escherichia coli K-12 substr. MG1655 Pathway: BaeSR Two-Component Signal Transduction System
Inferred from experiment

Pathway diagram: BaeSR Two-Component Signal Transduction System

Diagram Key:

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Genetic Regulation Schematic

Genetic regulation schematic for BaeSR Two-Component Signal Transduction System

Synonyms: BaeSR, BaeSR system

Superclasses: Signal transduction pathways

In E. coliK-12, two component systems (TCSs) sense and respond to changes in environmental conditions. Typically, a membrane associated sensor kinase autophosphorylates in response to an environmental signal. The sensor kinase then transfers a phosphoryl group to a response regulator (RR) which thus activated, effects a response. The majority of RRs in E. coli are transcription factors.

The BaeS and BaeR proteins are respectively, the sensor kinase and response regulator of the E. coli BaeSR two-component system [Nagasawa93]. The BaeSR TCS induces expression of spy in response to envelope stresses such as spheroblast formation or misfolded pilus subunits, leading to the suggestion that the BaeSR TCS is an envelope stress response pathway [Raffa02, BuryMone09]. baeS and baeR form an operon with the multidrug resistance cluster mdtABCD and BaeR binds to and stimulates the transcriptional activity of the mdtA promoter [Baranova02]. Overexpression of BaeR results in increased resistance to novobiocin and deoxycholate [Baranova02, Nagakubo02] but this phenotype is not dependent on the presence of BaeS [Baranova02].

Created 20-Jun-2010 by Mackie A, Macquarie University


Baranova02: Baranova N, Nikaido H (2002). "The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate." J Bacteriol 184(15);4168-76. PMID: 12107134

BuryMone09: Bury-Mone S, Nomane Y, Reymond N, Barbet R, Jacquet E, Imbeaud S, Jacq A, Bouloc P (2009). "Global analysis of extracytoplasmic stress signaling in Escherichia coli." PLoS Genet 5(9);e1000651. PMID: 19763168

Nagakubo02: Nagakubo S, Nishino K, Hirata T, Yamaguchi A (2002). "The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC." J Bacteriol 184(15);4161-7. PMID: 12107133

Nagasawa93: Nagasawa S, Ishige K, Mizuno T (1993). "Novel members of the two-component signal transduction genes in Escherichia coli." J Biochem (Tokyo) 1993;114(3);350-7. PMID: 8282725

Raffa02: Raffa RG, Raivio TL (2002). "A third envelope stress signal transduction pathway in Escherichia coli." Mol Microbiol 45(6);1599-611. PMID: 12354228

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Choudhury13: Choudhury HG, Beis K (2013). "The dimeric form of the unphosphorylated response regulator BaeR." Protein Sci 22(9);1287-93. PMID: 23868292

Daley05: Daley DO, Rapp M, Granseth E, Melen K, Drew D, von Heijne G (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308(5726);1321-3. PMID: 15919996

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Gao08: Gao R, Tao Y, Stock AM (2008). "System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids." Mol Microbiol 69(6);1358-72. PMID: 18631241

Gaudet10: Gaudet P, Livstone M, Thomas P (2010). "Annotation inferences using phylogenetic trees." PMID: 19578431

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Hirakawa03: Hirakawa H, Nishino K, Hirata T, Yamaguchi A (2003). "Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli." J Bacteriol 185(6);1851-6. PMID: 12618449

Hirakawa03a: Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A (2003). "Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli." J Antimicrob Chemother 52(4);576-82. PMID: 12951338

Hirakawa05: Hirakawa H, Inazumi Y, Masaki T, Hirata T, Yamaguchi A (2005). "Indole induces the expression of multidrug exporter genes in Escherichia coli." Mol Microbiol 55(4);1113-26. PMID: 15686558

Ishihama08: Ishihama Y, Schmidt T, Rappsilber J, Mann M, Hartl FU, Kerner MJ, Frishman D (2008). "Protein abundance profiling of the Escherichia coli cytosol." BMC Genomics 9;102. PMID: 18304323

Leblanc11: Leblanc SK, Oates CW, Raivio TL (2011). "Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli." J Bacteriol 193(13);3367-75. PMID: 21515766

Nishino05: Nishino K, Honda T, Yamaguchi A (2005). "Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system." J Bacteriol 187(5);1763-72. PMID: 15716448

Pao95: Pao GM, Saier MH (1995). "Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution." J Mol Evol 1995;40(2);136-54. PMID: 7699720

Parkinson92: Parkinson JS, Kofoid EC (1992). "Communication modules in bacterial signaling proteins." Annu Rev Genet 1992;26;71-112. PMID: 1482126

Parkinson93: Parkinson JS (1993). "Signal transduction schemes of bacteria." Cell 1993;73(5);857-71. PMID: 8098993

Rajagopala14: Rajagopala SV, Sikorski P, Kumar A, Mosca R, Vlasblom J, Arnold R, Franca-Koh J, Pakala SB, Phanse S, Ceol A, Hauser R, Siszler G, Wuchty S, Emili A, Babu M, Aloy P, Pieper R, Uetz P (2014). "The binary protein-protein interaction landscape of Escherichia coli." Nat Biotechnol 32(3);285-90. PMID: 24561554

Srivastava14: Srivastava SK, Lambadi PR, Ghosh T, Pathania R, Navani NK (2014). "Genetic regulation of spy gene expression in Escherichia coli in the presence of protein unfolding agent ethanol." Gene 548(1);142-8. PMID: 24999585

Stock00: Stock AM, Robinson VL, Goudreau PN (2000). "Two-component signal transduction." Annu Rev Biochem 69;183-215. PMID: 10966457

Stock90: Stock JB, Stock AM, Mottonen JM (1990). "Signal transduction in bacteria." Nature 1990;344(6265);395-400. PMID: 2157156

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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