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Escherichia coli K-12 substr. MG1655 Pathway: PRPP biosynthesis I
Inferred from experiment

Pathway diagram: PRPP biosynthesis I

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Genetic Regulation Schematic

Genetic regulation schematic for PRPP biosynthesis I

Synonyms: 5-phosphoribosyl 1-pyrophosphate biosynthesis

Superclasses: Degradation/Utilization/AssimilationInorganic Nutrients MetabolismPhosphorus Compounds MetabolismPRPP Biosynthesis

5-phospho-α-D-ribose 1-diphosphate (PRPP) is a pivotal metabolite; a total of 10 enzymes in a variety of biosynthesis and salvage pathways utilize PRPP as substrate. PRPP is synthesized from ribose 5-phosphate and ATP by ribose-phosphate diphosphokinase.

Superpathways: superpathway of histidine, purine, and pyrimidine biosynthesis

Variants: PRPP biosynthesis II

Last-Curated 16-Oct-2013 by Keseler I, SRI International


HoveJensen82: Hove-Jensen B, Nygaard P (1982). "Phosphoribosylpyrophosphate synthetase of Escherichia coli, Identification of a mutant enzyme." Eur J Biochem 126(2);327-32. PMID: 6290219

HoveJensen86: Hove-Jensen B, Harlow KW, King CJ, Switzer RL (1986). "Phosphoribosylpyrophosphate synthetase of Escherichia coli. Properties of the purified enzyme and primary structure of the prs gene." J Biol Chem 1986;261(15);6765-71. PMID: 3009477

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Ando96: Ando H, Kitabatake M, Inokuchi H (1996). "10Sa RNA complements the temperature-sensitive phenotype caused by a mutation in the phosphoribosyl pyrophosphate synthetase (prs) gene in Escherichia coli." Genes Genet Syst 71(1);47-50. PMID: 8925474

Bower89: Bower SG, Harlow KW, Switzer RL, Hove-Jensen B (1989). "Characterization of the Escherichia coli prsA1-encoded mutant phosphoribosylpyrophosphate synthetase identifies a divalent cation-nucleotide binding site." J Biol Chem 1989;264(17);10287-91. PMID: 2542328

BRENDA14: BRENDA team (2014). Imported from BRENDA version existing on Aug 2014.

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Fang13: Fang H, Xie X, Xu Q, Zhang C, Chen N (2013). "Enhancement of cytidine production by coexpression of gnd, zwf, and prs genes in recombinant Escherichia coli CYT15." Biotechnol Lett 35(2);245-51. PMID: 23070626

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

GOA06: GOA, SIB (2006). "Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins."

Hilden95: Hilden I, Hove-Jensen B, Harlow KW (1995). "Inactivation of Escherichia coli phosphoribosylpyrophosphate synthetase by the 2',3'-dialdehyde derivative of ATP. Identification of active site lysines." J Biol Chem 270(35);20730-6. PMID: 7657655

HoveJensen83: Hove-Jensen B (1983). "Chromosomal location of the gene encoding phosphoribosylpyrophosphate synthetase in Escherichia coli." J Bacteriol 154(1);177-84. PMID: 6300032

HoveJensen85: Hove-Jensen B (1985). "Cloning and characterization of the prs gene encoding phosphoribosylpyrophosphate synthetase of Escherichia coli." Mol Gen Genet 201(2);269-76. PMID: 3003529

HoveJensen88: Hove-Jensen B (1988). "Mutation in the phosphoribosylpyrophosphate synthetase gene (prs) that results in simultaneous requirements for purine and pyrimidine nucleosides, nicotinamide nucleotide, histidine, and tryptophan in Escherichia coli." J Bacteriol 170(3);1148-52. PMID: 2449419

HoveJensen89: Hove-Jensen B (1989). "Phosphoribosylpyrophosphate (PRPP)-less mutants of Escherichia coli." Mol Microbiol 3(11);1487-92. PMID: 2482407

HoveJensen96: Hove-Jensen B (1996). "Phosphoribosyl diphosphate synthetase-independent NAD de novo synthesis in Escherichia coli: a new phenotype of phosphate regulon mutants." J Bacteriol 178(3);714-22. PMID: 8550505

Ishihama08: Ishihama Y, Schmidt T, Rappsilber J, Mann M, Hartl FU, Kerner MJ, Frishman D (2008). "Protein abundance profiling of the Escherichia coli cytosol." BMC Genomics 9;102. PMID: 18304323

Karzai01: Karzai AW, Sauer RT (2001). "Protein factors associated with the SsrA.SmpB tagging and ribosome rescue complex." Proc Natl Acad Sci U S A 98(6);3040-4. PMID: 11248028

LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532

Nakano01: Nakano H, Goto S, Nakayashiki T, Inokuchi H (2001). "Temperature-sensitive mutations in various genes of Escherichia coli K12 can be suppressed by the ssrA gene for 10Sa RNA (tmRNA)." Mol Genet Genomics 265(4);615-21. PMID: 11459181

Neidhardt96: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE "Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition." American Society for Microbiology, Washington, D.C., 1996.

Post96: Post DA, Switzer RL, Hove-Jensen B (1996). "The defective phosphoribosyl diphosphate synthase in a temperature-sensitive prs-2 mutant of Escherichia coli is compensated by increased enzyme synthesis." Microbiology 142 ( Pt 2);359-65. PMID: 8932709

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon May 2, 2016, biocyc14.