If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
Synonyms: 5-phosphoribosyl 1-pyrophosphate biosynthesis
|Superclasses:||Degradation/Utilization/Assimilation → Inorganic Nutrients Metabolism → Phosphorus Compounds Metabolism → PRPP Biosynthesis|
5-phospho-α-D-ribose 1-diphosphate (PRPP) is a pivotal metabolite; a total of 10 enzymes in a variety of biosynthesis and salvage pathways utilize PRPP as substrate. PRPP is synthesized from ribose 5-phosphate and ATP by ribose-phosphate diphosphokinase.
Variants: PRPP biosynthesis II
HoveJensen86: Hove-Jensen B, Harlow KW, King CJ, Switzer RL (1986). "Phosphoribosylpyrophosphate synthetase of Escherichia coli. Properties of the purified enzyme and primary structure of the prs gene." J Biol Chem 1986;261(15);6765-71. PMID: 3009477
Ando96: Ando H, Kitabatake M, Inokuchi H (1996). "10Sa RNA complements the temperature-sensitive phenotype caused by a mutation in the phosphoribosyl pyrophosphate synthetase (prs) gene in Escherichia coli." Genes Genet Syst 71(1);47-50. PMID: 8925474
Bower89: Bower SG, Harlow KW, Switzer RL, Hove-Jensen B (1989). "Characterization of the Escherichia coli prsA1-encoded mutant phosphoribosylpyrophosphate synthetase identifies a divalent cation-nucleotide binding site." J Biol Chem 1989;264(17);10287-91. PMID: 2542328
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Fang13: Fang H, Xie X, Xu Q, Zhang C, Chen N (2013). "Enhancement of cytidine production by coexpression of gnd, zwf, and prs genes in recombinant Escherichia coli CYT15." Biotechnol Lett 35(2);245-51. PMID: 23070626
Hilden95: Hilden I, Hove-Jensen B, Harlow KW (1995). "Inactivation of Escherichia coli phosphoribosylpyrophosphate synthetase by the 2',3'-dialdehyde derivative of ATP. Identification of active site lysines." J Biol Chem 270(35);20730-6. PMID: 7657655
HoveJensen88: Hove-Jensen B (1988). "Mutation in the phosphoribosylpyrophosphate synthetase gene (prs) that results in simultaneous requirements for purine and pyrimidine nucleosides, nicotinamide nucleotide, histidine, and tryptophan in Escherichia coli." J Bacteriol 170(3);1148-52. PMID: 2449419
HoveJensen96: Hove-Jensen B (1996). "Phosphoribosyl diphosphate synthetase-independent NAD de novo synthesis in Escherichia coli: a new phenotype of phosphate regulon mutants." J Bacteriol 178(3);714-22. PMID: 8550505
LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532
Nakano01: Nakano H, Goto S, Nakayashiki T, Inokuchi H (2001). "Temperature-sensitive mutations in various genes of Escherichia coli K12 can be suppressed by the ssrA gene for 10Sa RNA (tmRNA)." Mol Genet Genomics 265(4);615-21. PMID: 11459181
Neidhardt96: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE "Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition." American Society for Microbiology, Washington, D.C., 1996.
Post96: Post DA, Switzer RL, Hove-Jensen B (1996). "The defective phosphoribosyl diphosphate synthase in a temperature-sensitive prs-2 mutant of Escherichia coli is compensated by increased enzyme synthesis." Microbiology 142 ( Pt 2);359-65. PMID: 8932709
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