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Escherichia coli K-12 substr. MG1655 Protein: 50S ribosomal subunit protein L7/L12 dimer



Gene: rplL Accession Numbers: EG10873 (EcoCyc), b3986, ECK3977

Regulation Summary Diagram

Regulation summary diagram for rplL

Component of:
50S ribosomal protein complex L8 (summary available)
50S ribosomal subunit
ribosome (summary available)

Subunit composition of 50S ribosomal subunit protein L7/L12 dimer = [RplL]2
         50S ribosomal subunit protein L12 = RplL

Alternative forms of 50S ribosomal subunit protein L12: 50S ribosomal subunit protein L7

Summary:
50S ribosomal subunit protein L7 is the N-acetylated form of 50S ribosomal subunit protein L12 [Terhorst73].

Gene Citations: [Ralling84 , Steward91, Barry80]

Locations: cytosol, ribosome

Map Position: [4,180,560 -> 4,180,925] (90.07 centisomes, 324°)
Length: 366 bp / 121 aa

Molecular Weight of Polypeptide: 12.295 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0013038, CGSC:254, DIP:DIP-36009N, EchoBASE:EB0866, EcoGene:EG10873, EcoliWiki:b3986, Mint:MINT-1277405, OU-Microarray:b3986, PortEco:rplL, PR:PRO_000023818, Pride:P0A7K2, Protein Model Portal:P0A7K2, RefSeq:NP_418413, RegulonDB:EG10873, SMR:P0A7K2, String:511145.b3986, UniProt:P0A7K2

Relationship Links: InterPro:IN-FAMILY:IPR000206, InterPro:IN-FAMILY:IPR008932, InterPro:IN-FAMILY:IPR013823, InterPro:IN-FAMILY:IPR014719, Panther:IN-FAMILY:PTHR11809, PDB:Structure:1CTF, PDB:Structure:1RQS, PDB:Structure:1RQT, PDB:Structure:1RQU, PDB:Structure:1RQV, PDB:Structure:2BCW, PDB:Structure:3J7Z, PDB:Structure:4UY8, PDB:Structure:4V4V, PDB:Structure:4V4W, PDB:Structure:4V5M, PDB:Structure:4V5N, PDB:Structure:4V7B, PDB:Structure:4V7D, PDB:Structure:4V9O, PDB:Structure:4V85, PDB:Structure:4V89, Pfam:IN-FAMILY:PF00542, Pfam:IN-FAMILY:PF16320, ProDom:IN-FAMILY:PD001326

Reactions known to consume the compound:

Not in pathways:
50S ribosomal subunit protein L12 + acetyl-CoA → 50S ribosomal subunit protein L7 + coenzyme A

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Genetic Regulation Schematic

Genetic regulation schematic for rplL


GO Terms:
Biological Process:
Inferred by computational analysisGO:0006412 - translation [GOA06, GOA01a]
Molecular Function:
Inferred by computational analysisGO:0003735 - structural constituent of ribosome [GOA01a]
Cellular Component:
Inferred from experimentInferred by computational analysisGO:0005829 - cytosol [DiazMejia09, Ishihama08, LopezCampistrou05]
Inferred from experimentGO:0022625 - cytosolic large ribosomal subunit [Hindennach71a, WittmannLiebold73]
GO:0005622 - intracellular []
Inferred by computational analysisGO:0005840 - ribosome [UniProtGOA11a, GOA01a]
Inferred by computational analysisGO:0030529 - intracellular ribonucleoprotein complex [UniProtGOA11a]

MultiFun Terms: cell structureribosomes
information transferprotein relatedribosomal proteins
information transferprotein relatedtranslation

Essentiality data for rplL knockouts:

Growth Medium Growth? T (°C) O2 pH Osm/L Growth Observations
LB LennoxNo 37 Aerobic 7   No [Baba06, Comment 1]

Credits:
Created 05-Apr-2006 by Keseler I, SRI International


Subunit of: 50S ribosomal protein complex L8

Subunit composition of 50S ribosomal protein complex L8 = [RplJ][(RplL)2]2
         50S ribosomal subunit protein L10 = RplJ (extended summary available)
         50S ribosomal subunit protein L7/L12 dimer = (RplL)2
                 50S ribosomal subunit protein L12 = RplL

Component of: 50S ribosomal subunit

Summary:
The ribosomal proteins L10 and L7/L12 form a complex of two L7/L12 dimers and one L10 monomer; the complex can be isolated both in solution and from intact ribosomes and was previously identified as L8 [Pettersson76, Chu76, Osterberg77, Gudkov78]. The conformation of the L8 complex and changes in L7/L12 dimer conformation upon binding to the ribosome or L10 has been studied [Makarov93, Hamman96, Bocharov98].

The binding site within 23S rRNA of the L8 complex has been determined [Beauclerk84, Rosendahl93].

Credits:
Created 05-Apr-2006 by Keseler I, SRI International
Last-Curated 05-Apr-2006 by Keseler I, SRI International


Subunit of: 50S ribosomal subunit

Inferred from experiment

Synonyms: ribosome, large subunit

Subunit composition of 50S ribosomal subunit = [RrlA][RrfA][RplA][RplB][RplC][RplD][RplE][RplF][(RplJ)([RplL]2)2][RplI][RplK][RplM][RplN][RplO][RplP][RplQ][RplR][RplS][RplT][RplU][RplV][RplW][RplX][RplY][RpmA][RpmB][RpmC][RpmD][RpmE][RpmF][RpmG][RpmH][RpmI][RpmJ]
         23S ribosomal RNA (rrlA) = RrlA (extended summary available)
         5S ribosomal RNA (rrfA) = RrfA (extended summary available)
         50S ribosomal subunit protein L1 = RplA (extended summary available)
         50S ribosomal subunit protein L2 = RplB (summary available)
         50S ribosomal subunit protein L3 = RplC (summary available)
         50S ribosomal subunit protein L4 = RplD (extended summary available)
         50S ribosomal subunit protein L5 = RplE (extended summary available)
         50S ribosomal subunit protein L6 = RplF (summary available)
         50S ribosomal protein complex L8 = (RplJ)([RplL]2)2 (summary available)
                 50S ribosomal subunit protein L10 = RplJ (extended summary available)
                 50S ribosomal subunit protein L7/L12 dimer = (RplL)2
                         50S ribosomal subunit protein L12 = RplL
         50S ribosomal subunit protein L9 = RplI (extended summary available)
         50S ribosomal subunit protein L11 = RplK (extended summary available)
         50S ribosomal subunit protein L13 = RplM (extended summary available)
         50S ribosomal subunit protein L14 = RplN (extended summary available)
         50S ribosomal subunit protein L15 = RplO (summary available)
         50S ribosomal subunit protein L16 = RplP (extended summary available)
         50S ribosomal subunit protein L17 = RplQ (summary available)
         50S ribosomal subunit protein L18 = RplR (extended summary available)
         50S ribosomal subunit protein L19 = RplS (extended summary available)
         50S ribosomal subunit protein L20 = RplT (extended summary available)
         50S ribosomal subunit protein L21 = RplU (summary available)
         50S ribosomal subunit protein L22 = RplV (extended summary available)
         50S ribosomal subunit protein L23 = RplW (extended summary available)
         50S ribosomal subunit protein L24 = RplX (summary available)
         50S ribosomal subunit protein L25 = RplY (extended summary available)
         50S ribosomal subunit protein L27 = RpmA (extended summary available)
         50S ribosomal subunit protein L28 = RpmB (summary available)
         50S ribosomal subunit protein L29 = RpmC (summary available)
         50S ribosomal subunit protein L30 = RpmD (summary available)
         50S ribosomal subunit protein L31 = RpmE (summary available)
         50S ribosomal subunit protein L32 = RpmF (summary available)
         50S ribosomal subunit protein L33 = RpmG (extended summary available)
         50S ribosomal subunit protein L34 = RpmH (summary available)
         50S ribosomal subunit protein L35 = RpmI (summary available)
         50S ribosomal subunit protein L36 = RpmJ (extended summary available)

Component of: ribosome (summary available)

Relationship Links: PDB:Structure:1P85, PDB:Structure:1P86, PDB:Structure:2AW4, PDB:Structure:2AWB

Enzymatic reactions activated by 50S ribosomal subunit, sorted by the type of activation, are:

Activator (Mechanism unknown) of: GTPase [Jain09, Shields09]

Credits:
Created 02-Jun-2006 by Keseler I, SRI International


Subunit of: ribosome

Subunit composition of ribosome = [(RrsA)(RpsA)(RpsB)(RpsC)(RpsD)(RpsE)(RpsF)(RpsG)(RpsH)(RpsI)(RpsJ)(RpsK)(RpsL)(RpsM)(RpsN)(RpsO)(RpsP)(RpsQ)(RpsR)(RpsS)(RpsT)(RpsU)(Sra)][(RrlA)(RrfA)(RplA)(RplB)(RplC)(RplD)(RplE)(RplF)([RplJ][(RplL)2]2)(RplI)(RplK)(RplM)(RplN)(RplO)(RplP)(RplQ)(RplR)(RplS)(RplT)(RplU)(RplV)(RplW)(RplX)(RplY)(RpmA)(RpmB)(RpmC)(RpmD)(RpmE)(RpmF)(RpmG)(RpmH)(RpmI)(RpmJ)]
         30S ribosomal subunit = (RrsA)(RpsA)(RpsB)(RpsC)(RpsD)(RpsE)(RpsF)(RpsG)(RpsH)(RpsI)(RpsJ)(RpsK)(RpsL)(RpsM)(RpsN)(RpsO)(RpsP)(RpsQ)(RpsR)(RpsS)(RpsT)(RpsU)(Sra) (summary available)
                 16S ribosomal RNA (rrsA) = RrsA (extended summary available)
                 30S ribosomal subunit protein S1 = RpsA (extended summary available)
                 30S ribosomal subunit protein S2 = RpsB (summary available)
                 30S ribosomal subunit protein S3 = RpsC (summary available)
                 30S ribosomal subunit protein S4 = RpsD (extended summary available)
                 30S ribosomal subunit protein S5 = RpsE (extended summary available)
                 30S ribosomal subunit protein S6 = RpsF (extended summary available)
                 30S ribosomal subunit protein S7 = RpsG (extended summary available)
                 30S ribosomal subunit protein S8 = RpsH (extended summary available)
                 30S ribosomal subunit protein S9 = RpsI (extended summary available)
                 30S ribosomal subunit protein S10 = RpsJ (extended summary available)
                 30S ribosomal subunit protein S11 = RpsK (summary available)
                 30S ribosomal subunit protein S12 = RpsL (extended summary available)
                 30S ribosomal subunit protein S13 = RpsM (extended summary available)
                 30S ribosomal subunit protein S14 = RpsN (summary available)
                 30S ribosomal subunit protein S15 = RpsO (extended summary available)
                 30S ribosomal subunit protein S16 = RpsP (summary available)
                 30S ribosomal subunit protein S17 = RpsQ (summary available)
                 30S ribosomal subunit protein S18 = RpsR (extended summary available)
                 30S ribosomal subunit protein S19 = RpsS (summary available)
                 30S ribosomal subunit protein S20 = RpsT (extended summary available)
                 30S ribosomal subunit protein S21 = RpsU (summary available)
                 30S ribosomal subunit protein S22 = Sra (summary available)
         50S ribosomal subunit = (RrlA)(RrfA)(RplA)(RplB)(RplC)(RplD)(RplE)(RplF)([RplJ][(RplL)2]2)(RplI)(RplK)(RplM)(RplN)(RplO)(RplP)(RplQ)(RplR)(RplS)(RplT)(RplU)(RplV)(RplW)(RplX)(RplY)(RpmA)(RpmB)(RpmC)(RpmD)(RpmE)(RpmF)(RpmG)(RpmH)(RpmI)(RpmJ)
                 23S ribosomal RNA (rrlA) = RrlA (extended summary available)
                 5S ribosomal RNA (rrfA) = RrfA (extended summary available)
                 50S ribosomal subunit protein L1 = RplA (extended summary available)
                 50S ribosomal subunit protein L2 = RplB (summary available)
                 50S ribosomal subunit protein L3 = RplC (summary available)
                 50S ribosomal subunit protein L4 = RplD (extended summary available)
                 50S ribosomal subunit protein L5 = RplE (extended summary available)
                 50S ribosomal subunit protein L6 = RplF (summary available)
                 50S ribosomal protein complex L8 = (RplJ)([RplL]2)2 (summary available)
                         50S ribosomal subunit protein L10 = RplJ (extended summary available)
                         50S ribosomal subunit protein L7/L12 dimer = (RplL)2
                                 50S ribosomal subunit protein L12 = RplL
                 50S ribosomal subunit protein L9 = RplI (extended summary available)
                 50S ribosomal subunit protein L11 = RplK (extended summary available)
                 50S ribosomal subunit protein L13 = RplM (extended summary available)
                 50S ribosomal subunit protein L14 = RplN (extended summary available)
                 50S ribosomal subunit protein L15 = RplO (summary available)
                 50S ribosomal subunit protein L16 = RplP (extended summary available)
                 50S ribosomal subunit protein L17 = RplQ (summary available)
                 50S ribosomal subunit protein L18 = RplR (extended summary available)
                 50S ribosomal subunit protein L19 = RplS (extended summary available)
                 50S ribosomal subunit protein L20 = RplT (extended summary available)
                 50S ribosomal subunit protein L21 = RplU (summary available)
                 50S ribosomal subunit protein L22 = RplV (extended summary available)
                 50S ribosomal subunit protein L23 = RplW (extended summary available)
                 50S ribosomal subunit protein L24 = RplX (summary available)
                 50S ribosomal subunit protein L25 = RplY (extended summary available)
                 50S ribosomal subunit protein L27 = RpmA (extended summary available)
                 50S ribosomal subunit protein L28 = RpmB (summary available)
                 50S ribosomal subunit protein L29 = RpmC (summary available)
                 50S ribosomal subunit protein L30 = RpmD (summary available)
                 50S ribosomal subunit protein L31 = RpmE (summary available)
                 50S ribosomal subunit protein L32 = RpmF (summary available)
                 50S ribosomal subunit protein L33 = RpmG (extended summary available)
                 50S ribosomal subunit protein L34 = RpmH (summary available)
                 50S ribosomal subunit protein L35 = RpmI (summary available)
                 50S ribosomal subunit protein L36 = RpmJ (extended summary available)

Summary:
The ribosome is a complex machinery that translates the genetic code.

A crystal structure of the E. coli ribosome has been determined at 3.5 Å resolution [Schuwirth05]. Additional crystal structures of the ribosome with tRNA bound in two functionally distinct states reveal how a ratchet-like motion of the small and large subunits contributes to translocation, termination of translation, and ribosome recycling [Zhang09a, Dunkle11].

Approximately eight molecules of Zn2+ are bound to the ribosome; therefore, it appears that a large fraction of intracellular Zn2+ is ribosome-associated [Hensley11].

Selected reviews: [Ramakrishnan02, Yonath05, Ogle05, Kaczanowska07]

Citations: [Kuhlenkoetter11, Goldman15]

Relationship Links: PDB:Structure:3R8N, PDB:Structure:3R8O, PDB:Structure:3R8S, PDB:Structure:3R8T

Enzymatic reactions activated by ribosome, sorted by the type of activation, are:

Activator (Mechanism unknown) of: GTPase [Shields09], GTPase, ribosome-stimulated [De15], ATPase [Becker12]

Credits:
Created 15-Jun-2006 by Keseler I, SRI International


Sequence Features

Protein sequence of 50S ribosomal subunit protein L12 with features indicated

Feature Class Location Citations Comment
Cleavage-of-Initial-Methionine 1
Inferred from experiment[Wasinger98, Wilkins98, Link97, Pettersson76, Terhorst73, Pettersson76, Terhorst73, Wilkins98, Wasinger98, Link97]
 
Acetylation-Modification 2
Inferred from experiment[Terhorst73]
UniProt: N-acetylserine; in L7.
Chain 2 -> 121
Author statement[UniProt15]
UniProt: 50S ribosomal protein L7/L12.
Sequence-Conflict 6
Inferred by curator[Wasinger98, UniProt15]
UniProt: (in Ref. 9; AA sequence).
Protein-Segment 54 -> 121
Author statement[UniProt15]
UniProt: Required for recruitment of EF-Tu and EF-G, and for EF-Tu and EF-G-promoted GTP hydrolysis; Sequence Annotation Type: region of interest.
Mutagenesis-Variant 66
Inferred from experiment[Diaconu05]
UniProt: EF-Tu-binding and EF-Tu-promoted GTP hydrolysis reduced.
Mutagenesis-Variant 67
Inferred from experiment[Diaconu05]
UniProt: EF-Tu-binding and EF-Tu-promoted GTP hydrolysis reduced.
Mutagenesis-Variant 70
Inferred from experiment[Diaconu05]
UniProt: EF-Tu-binding and EF-Tu-promoted GTP hydrolysis reduced.
Mutagenesis-Variant 71
Inferred from experiment[Diaconu05]
UniProt: EF-Tu-binding and EF-Tu-promoted GTP hydrolysis reduced.
Mutagenesis-Variant 74
Inferred from experiment[Diaconu05]
UniProt: EF-Tu-binding and EF-Tu-promoted GTP hydrolysis reduced.
Modified-Residue 82
Inferred from experiment[Terhorst73]
UniProt: N6-methyllysine; partial.
Mutagenesis-Variant 85
Inferred from experiment[Diaconu05]
UniProt: EF-Tu-binding and EF-Tu-promoted GTP hydrolysis reduced.


Sequence Pfam Features

Protein sequence of 50S ribosomal subunit protein L12 with features indicated

Feature Class Location Citations Comment
Pfam PF16320 4 -> 50
Inferred by computational analysis[Finn14]
Ribosomal_L12_N : Ribosomal protein L7/L12 dimerisation domain [More...]
Pfam PF00542 55 -> 121
Inferred by computational analysis[Finn14]
Ribosomal_L12 : Ribosomal protein L7/L12 C-terminal domain


Gene Local Context (not to scale -- see Genome Browser for correct scale)

Transcription Units

Transcription-unit diagram

Transcription-unit diagram

Transcription-unit diagram

Transcription-unit diagram

Notes:

History:
10/20/97 Gene b3986 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG10873; confirmed by SwissProt match.


References

Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

Barry80: Barry G, Squires C, Squires CL (1980). "Attenuation and processing of RNA from the rplJL--rpoBC transcription unit of Escherichia coli." Proc Natl Acad Sci U S A 77(6);3331-5. PMID: 6158044

Beauclerk84: Beauclerk AA, Cundliffe E, Dijk J (1984). "The binding site for ribosomal protein complex L8 within 23 s ribosomal RNA of Escherichia coli." J Biol Chem 259(10);6559-63. PMID: 6373761

Becker12: Becker M, Gzyl KE, Altamirano AM, Vuong A, Urban K, Wieden HJ (2012). "The 70S ribosome modulates the ATPase activity of Escherichia coli YchF." RNA Biol 9(10);1288-301. PMID: 22995830

Bocharov98: Bocharov EV, Gudkov AT, Budovskaya EV, Arseniev AS (1998). "Conformational independence of N- and C-domains in ribosomal protein L7/L12 and in the complex with protein L10." FEBS Lett 423(3);347-50. PMID: 9515737

Chu76: Chu F, Caldwell P, Samuels M, Weissbach H, Brot N (1976). "DNA-dependent in vitro synthesis of Escherichia coli ribosomal protein L10 and the formation of an L10L12 complex." Biochem Biophys Res Commun 76(2);593-601. PMID: 800342

De15: De Laurentiis EI, Wieden HJ (2015). "Identification of two structural elements important for ribosome-dependent GTPase activity of elongation factor 4 (EF4/LepA)." Sci Rep 5;8573. PMID: 25712150

Diaconu05: Diaconu M, Kothe U, Schlunzen F, Fischer N, Harms JM, Tonevitsky AG, Stark H, Rodnina MV, Wahl MC (2005). "Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation." Cell 121(7);991-1004. PMID: 15989950

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Dunkle11: Dunkle JA, Wang L, Feldman MB, Pulk A, Chen VB, Kapral GJ, Noeske J, Richardson JS, Blanchard SC, Cate JH (2011). "Structures of the bacterial ribosome in classical and hybrid states of tRNA binding." Science 332(6032);981-4. PMID: 21596992

Finn14: Finn RD, Bateman A, Clements J, Coggill P, Eberhardt RY, Eddy SR, Heger A, Hetherington K, Holm L, Mistry J, Sonnhammer EL, Tate J, Punta M (2014). "Pfam: the protein families database." Nucleic Acids Res 42(Database issue);D222-30. PMID: 24288371

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

GOA06: GOA, SIB (2006). "Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins."

Goldman15: Goldman DH, Kaiser CM, Milin A, Righini M, Tinoco I, Bustamante C (2015). "Ribosome. Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo." Science 348(6233);457-60. PMID: 25908824

Gudkov78: Gudkov AT, Tumanova LG, Venyaminov SY, Khechinashvilli NN (1978). "Stoichiometry and properties of the complex between ribosomal proteins L7 and L10 in solution." FEBS Lett 93(2);215-8. PMID: 361431

Hamman96: Hamman BD, Oleinikov AV, Jokhadze GG, Bochkariov DE, Traut RR, Jameson DM (1996). "Tetramethylrhodamine dimer formation as a spectroscopic probe of the conformation of Escherichia coli ribosomal protein L7/L12 dimers." J Biol Chem 271(13);7568-73. PMID: 8631789

Hensley11: Hensley MP, Tierney DL, Crowder MW (2011). "Zn(II) binding to Escherichia coli 70S ribosomes." Biochemistry 50(46);9937-9. PMID: 22026583

Hindennach71a: Hindennach I, Kaltschmidt E, Wittmann HG (1971). "Ribosomal proteins. Isolation of proteins from 50S ribosomal subunits of Escherichia coli." Eur J Biochem 23(1);12-6. PMID: 4942547

Hui82: Hui I, Maltman K, Little R, Hastrup S, Johnsen M, Fiil N, Dennis P (1982). "Insertions of transposon Tn5 into ribosomal protein PNA polymerase operons." J Bacteriol 152(3);1022-32. PMID: 6292159

Ishihama08: Ishihama Y, Schmidt T, Rappsilber J, Mann M, Hartl FU, Kerner MJ, Frishman D (2008). "Protein abundance profiling of the Escherichia coli cytosol." BMC Genomics 9;102. PMID: 18304323

Jain09: Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B (2009). "E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides." Biochem Biophys Res Commun 379(2);201-5. PMID: 19109926

Kaczanowska07: Kaczanowska M, Ryden-Aulin M (2007). "Ribosome biogenesis and the translation process in Escherichia coli." Microbiol Mol Biol Rev 71(3);477-94. PMID: 17804668

Kuhlenkoetter11: Kuhlenkoetter S, Wintermeyer W, Rodnina MV (2011). "Different substrate-dependent transition states in the active site of the ribosome." Nature 476(7360);351-4. PMID: 21804565

Link97: Link AJ, Robison K, Church GM (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18(8);1259-313. PMID: 9298646

LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532

Makarov93: Makarov EM, Oleinikov AV, Zecherle GN, Traut RR (1993). "Zero-length cross-linking of the C-terminal domain of Escherichia coli ribosomal protein L7/L12 to L10 in the ribosome and in the (L7/L12)4-L10 pentameric complex." Biochimie 75(11);963-9. PMID: 8123703

Ogle05: Ogle JM, Ramakrishnan V (2005). "Structural insights into translational fidelity." Annu Rev Biochem 74;129-77. PMID: 15952884

Osterberg77: Osterberg R, Sjoberg B, Pettersson I, Liljas A, Kurland CG (1977). "Small-angle x-ray scattering study of the protein complex of L7/L12 and L10 from Escherichia coli ribosomes." FEBS Lett 73(1);22-4. PMID: 320036

Pettersson76: Pettersson I, Hardy SJ, Liljas A (1976). "The ribosomal protein L8 is a complex L7/L12 and L10." FEBS Lett 64(1);135-8. PMID: 773698

Ralling84: Ralling G, Linn T (1984). "Relative activities of the transcriptional regulatory sites in the rplKAJLrpoBC gene cluster of Escherichia coli." J Bacteriol 158(1);279-85. PMID: 6325390

Ramakrishnan02: Ramakrishnan V (2002). "Ribosome structure and the mechanism of translation." Cell 108(4);557-72. PMID: 11909526

Rosendahl93: Rosendahl G, Douthwaite S (1993). "Ribosomal proteins L11 and L10.(L12)4 and the antibiotic thiostrepton interact with overlapping regions of the 23 S rRNA backbone in the ribosomal GTPase centre." J Mol Biol 234(4);1013-20. PMID: 8263910

Schuwirth05: Schuwirth BS, Borovinskaya MA, Hau CW, Zhang W, Vila-Sanjurjo A, Holton JM, Cate JH (2005). "Structures of the bacterial ribosome at 3.5 A resolution." Science 310(5749);827-34. PMID: 16272117

Shields09: Shields MJ, Fischer JJ, Wieden HJ (2009). "Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach." Biochemistry 48(45);10793-802. PMID: 19824612

Steward91: Steward KL, Linn T (1991). "In vivo analysis of overlapping transcription units in the rplKAJLrpoBC ribosomal protein-RNA polymerase gene cluster of Escherichia coli." J Mol Biol 218(1);23-31. PMID: 1825852

Terhorst73: Terhorst C, Moller W, Laursen R, Wittmann-Liebold B (1973). "The primary structure of an acidic protein from 50-S ribosomes of Escherichia coli which is involved in GTP hydrolysis dependent on elongation factors G and T." Eur J Biochem 34(1);138-52. PMID: 4573678

UniProt15: UniProt Consortium (2015). "UniProt version 2015-08 released on 2015-07-22." Database.

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

Wasinger98: Wasinger VC, Humphery-Smith I (1998). "Small genes/gene-products in Escherichia coli K-12." FEMS Microbiol Lett 169(2);375-82. PMID: 9868784

Wilkins98: Wilkins MR, Gasteiger E, Tonella L, Ou K, Tyler M, Sanchez JC, Gooley AA, Walsh BJ, Bairoch A, Appel RD, Williams KL, Hochstrasser DF (1998). "Protein identification with N and C-terminal sequence tags in proteome projects." J Mol Biol 278(3);599-608. PMID: 9600841

WittmannLiebold73: Wittmann-Liebold B (1973). "Studies on the primary structure of 20 proteins from Escherichia coli ribosomes by means of an improved protein sequenator." FEBS Lett 36(3);247-9. PMID: 4587209

Yonath05: Yonath A (2005). "Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation." Annu Rev Biochem 74;649-79. PMID: 16180279

Zhang09a: Zhang W, Dunkle JA, Cate JH (2009). "Structures of the ribosome in intermediate states of ratcheting." Science 325(5943);1014-7. PMID: 19696352

Other References Related to Gene Regulation

Baughman83: Baughman G, Nomura M (1983). "Localization of the target site for translational regulation of the L11 operon and direct evidence for translational coupling in Escherichia coli." Cell 34(3);979-88. PMID: 6354472

Baughman84: Baughman G, Nomura M (1984). "Translational regulation of the L11 ribosomal protein operon of Escherichia coli: analysis of the mRNA target site using oligonucleotide-directed mutagenesis." Proc Natl Acad Sci U S A 81(17);5389-93. PMID: 6382263

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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