Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:
1-acylglycerol-3-phosphate O-acyltransferaseInferred from experiment: plsC

In Pathway: CDP-diacylglycerol biosynthesis II

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-acylglycerol-3-phosphate O-acyltransferase

Enzyme Commission Synonyms: 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, lysophosphatidic acid-acyltransferase

This is the second step in de novo phospholipid biosynthesis in which a second fatty acid is esterified at C2 of the glycerol moiety.

Enzyme Commission Summary:
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.

Citations: [Frentzen83, Hill68, Yamashita73]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a long-chain acyl-CoA + a 1-acyl-sn-glycerol 3-phosphate → a 1,2-diacyl-sn-glycerol 3-phosphate + coenzyme A] (
i1: palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate → 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A (

i2: palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate → 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A (

i3: palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate → 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A (

i4: cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate → 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A (

i5: cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate → 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A (

i6: 1-palmitoylglycerol 3-phosphate + myristoyl-CoA → 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A (

i7: myristoyl-CoA + 1-myristoylglycerol 3-phosphate → dimyristoyl phosphatidate + coenzyme A (

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Frentzen83: Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts." Eur J Biochem 129(3);629-36. PMID: 6825679

Hill68: Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine." Biochim Biophys Acta 152(3);645-8. PMID: 5661029

Yamashita73: Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes." Eur J Biochem 38(1);25-31. PMID: 4774123

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Nov 28, 2015, biocyc14.