Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 3.1.26.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.26.3

Enzymes and Genes:
RNase III Inferred from experiment : rnc

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: ribonuclease III

Enzyme Commission Synonyms: RNase III, ribonuclease 3

Summary:
This reaction is the endonucleolytic cleavage of double-stranded RNA to yield a 5'-phosphate and a 3'-hydroxyl.

Enzyme Commission Summary:
This is an endoribonuclease that cleaves double-stranded RNA molecules [GrunbergManago99]. The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site . Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage [Zhang97b]. RNase III is involved in both rRNA processing and mRNA processing and decay.

Citations: [Crouch74, Rech80, Robertson68, Robertson75]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.1.26.3 , ENZYME:EC:3.1.26.3 , IUBMB-ExplorEnz:EC:3.1.26.3


References

Crouch74: Crouch RJ (1974). "Ribonuclease 3 does not degrade deoxyribonucleic acid-ribonucleic acid hybrids." J Biol Chem 249(4);1314-6. PMID: 4592261

GrunbergManago99: Grunberg-Manago M (1999). "Messenger RNA stability and its role in control of gene expression in bacteria and phages." Annu Rev Genet 33;193-227. PMID: 10690408

Rech80: Rech J, Cathala G, Jeanteur P (1980). "Isolation and characterization of a ribonuclease activity specific for double-stranded RNA (RNase D) from Krebs II ascites cells." J Biol Chem 255(14);6700-6. PMID: 6248530

Robertson68: Robertson HD, Webster RE, Zinder ND (1968). "Purification and properties of ribonuclease III from Escherichia coli." J Biol Chem 243(1);82-91. PMID: 4865702

Robertson75: Robertson HD, Dunn JJ (1975). "Ribonucleic acid processing activity of Escherichia coli ribonuclease III." J Biol Chem 250(8);3050-6. PMID: 1091644

Zhang97b: Zhang K, Nicholson AW (1997). "Regulation of ribonuclease III processing by double-helical sequence antideterminants." Proc Natl Acad Sci U S A 94(25);13437-41. PMID: 9391043


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC13B.