Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
RNase PInferred from experiment: rnpB, rnpA

In Pathway: tRNA processing

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: ribonuclease P

Enzyme Commission Synonyms: RNase P

This is the endonucleolytic cleavage of RNA to remove the excess 5' nucleotide from tRNA precursor, yielding the final 5' terminus of a mature tRNA.

Enzyme Commission Summary:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.

Citations: [Bikoff75, Bikoff75a , Robertson72]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Bikoff75: Bikoff EK, Gefter ML (1975). "In vitro synthesis of transfer RNA. I. Purification of required components." J Biol Chem 250(16);6240-7. PMID: 1099089

Bikoff75a: Bikoff EK, LaRue BF, Gefter ML (1975). "In vitro synthesis of transfer RNA. II. Identification of required enzymatic activities." J Biol Chem 250(16);6248-55. PMID: 1099090

Robertson72: Robertson HD, Altman S, Smith JD (1972). "Purification and properties of a specific Escherichia coli ribonuclease which cleaves a tyrosine transfer ribonucleic acid presursor." J Biol Chem 247(16);5243-51. PMID: 4560501

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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