|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.111
In Pathway: pentose phosphate pathway (oxidative branch) I
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
While the official EC reaction includes NADP+ rather than NAD(P)+, the comments state that some preparations reduce NAD+ as well as NADP+, making NAD(P)+ a more accurate depiction.
Enzyme Commission Summary:
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 18.104.22.168, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP and can accept both cofactors with similar efficiency. cf. EC 22.214.171.1243, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
BenBassat80: Ben-Bassat A, Goldberg I (1980). "Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C." Biochim Biophys Acta 611(1);1-10. PMID: 7350909
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