Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reaction:
D-gluconate 6-phosphate + NADP+ → D-ribulose 5-phosphate + CO2 + NADPH (

Enzyme Commission Primary Name: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]

While the official EC reaction includes NADP+ rather than NAD(P)+, the comments state that some preparations reduce NAD+ as well as NADP+, making NAD(P)+ a more accurate depiction.

Enzyme Commission Summary:
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP and can accept both cofactors with similar efficiency. cf. EC, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).

Citations: [BenBassat80, Stournaras83]

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


BenBassat80: Ben-Bassat A, Goldberg I (1980). "Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C." Biochim Biophys Acta 611(1);1-10. PMID: 7350909

Stournaras83: Stournaras C, Maurer P, Kurz G (1983). "6-phospho-D-gluconate dehydrogenase from Pseudomonas fluorescens. Properties and subunit structure." Eur J Biochem 130(2);391-6. PMID: 6402366

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Tue Mar 31, 2015, biocyc14.