Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 1.1.1.351

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.351

In Pathway: pentose phosphate pathway (oxidative branch) I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reaction:
D-gluconate 6-phosphate + NADP+ → D-ribulose 5-phosphate + CO2 + NADPH (1.1.1.44)

Enzyme Commission Primary Name: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]

Summary:
While the official EC reaction includes NADP+ rather than NAD(P)+, the comments state that some preparations reduce NAD+ as well as NADP+, making NAD(P)+ a more accurate depiction.

Enzyme Commission Summary:
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).

Citations: [BenBassat80, Stournaras83]

Relationship Links: BRENDA:EC:1.1.1.351 , ENZYME:EC:1.1.1.351 , IUBMB-ExplorEnz:EC:1.1.1.351


References

BenBassat80: Ben-Bassat A, Goldberg I (1980). "Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C." Biochim Biophys Acta 611(1);1-10. PMID: 7350909

Stournaras83: Stournaras C, Maurer P, Kurz G (1983). "6-phospho-D-gluconate dehydrogenase from Pseudomonas fluorescens. Properties and subunit structure." Eur J Biochem 130(2);391-6. PMID: 6402366


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13A.