Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsTransport Energized by Phosphoanhydride-Bond Hydrolysi
Reactions Classified By Conversion TypeSimple ReactionsTransport ReactionsTransport Energized by Phosphoanhydride-Bond Hydrolysi
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Transporters and Genes:
ferric citrate ABC transporterInferred from experimentInferred by computational analysis: fecE, fecC, fecD, fecB

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

Transport reaction diagram

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: iron-chelate-transporting ATPase

Enzyme Commission Synonyms:

Enzyme Commission Summary:
ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores.

Citations: [Shea91, Koster92, Kuan95, Saier98, Mademidis98]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Koster92: Koster W, Bohm B (1992). "Point mutations in two conserved glycine residues within the integral membrane protein FhuB affect iron(III) hydroxamate transport." Mol Gen Genet 232(3);399-407. PMID: 1588908

Kuan95: Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases." Res Microbiol 146(4);271-8. PMID: 7569321

Mademidis98: Mademidis A, Koster W (1998). "Transport activity of FhuA, FhuC, FhuD, and FhuB derivatives in a system free of polar effects, and stoichiometry of components involved in ferrichrome uptake." Mol Gen Genet 1998;258(1-2);156-65. PMID: 9613584

Saier98: Saier MH (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya." Adv Microb Physiol 40;81-136. PMID: 9889977

Shea91: Shea CM, McIntosh MA (1991). "Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli." Mol Microbiol 1991;5(6);1415-28. PMID: 1838574

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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