|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
220.127.116.11: citrate = D-threo-isocitrate
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
The nonoxidizable tertiary alcohol in citrate is converted to an oxidizable secondary alcohol in isocitrate. Cis-aconitate is the unsaturated intermediate.
The prpD gene encodes 2-methylcitrate dehydratase activity [Blank02] and also encodes the minor aconitase activity, aconitase C [Blank02], which constitutes 5% or less of cellular activity and is observed in an acnA acnB double mutant [Gruer97].
Blank02: Blank L, Green J, Guest JR (2002). "AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates." Microbiology 148(Pt 1);133-46. PMID: 11782506
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