Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
thioesterase IIInferred from experiment: tesB
acyl-CoA thioesteraseInferred from experiment: yciA

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
(S)-3-hydroxybutanoyl-CoA + H2O → (S)-3-hydroxybutanoate + coenzyme A + H+ (no EC#)

(R)-3-hydroxybutanoyl-CoA + H2O → (R)-3-hydroxybutanoate + coenzyme A + H+ (no EC#)

Enzyme Commission Primary Name: acyl-CoA hydrolase

Enzyme Commission Synonyms: acyl coenzyme A thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, acyl-CoA thioesterase

Enzyme Commission Summary:
Broad specificity for medium- to long-chain acyl-CoA. Insensitive to NAD+ (cf. EC ADP-dependent medium-chain-acyl-CoA hydrolase).

Citations: [Alexson89]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [an acyl-CoA + H2O → a carboxylate + coenzyme A + H+] (
i1: (S)-3-hydroxybutanoyl-CoA + H2O → (S)-3-hydroxybutanoate + coenzyme A + H+ (no EC#)

i2: (R)-3-hydroxybutanoyl-CoA + H2O → (R)-3-hydroxybutanoate + coenzyme A + H+ (no EC#)

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Alexson89: Alexson SE, Svensson LT, Nedergaard J (1989). "NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat." Biochim Biophys Acta 1005(1);13-9. PMID: 2570608

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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