Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 1.1.1.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.2

Enzymes and Genes:
NADP+-dependent aldehyde reductase Inferred from experiment : ybbO
aldehyde reductase, NADPH-dependent Inferred from experiment : ahr
aldehyde reductase, NADPH-dependent Inferred from experiment : yahK
NADPH-dependent aldehyde reductase Inferred from experiment : yqhD

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Instance reactions:
(S)-propane-1,2-diol + NADP+ = (S)-lactaldehyde + NADPH + H+ (1.1.1.-)

(R)-propane-1,2-diol + NADP+ = (R)-lactaldehyde + NADPH + H+ (1.1.1.-)

Enzyme Commission Primary Name: alcohol dehydrogenase (NADP+)

Enzyme Commission Synonyms: aldehyde reductase (NADPH2), NADP-alcohol dehydrogenase, NADP+-aldehyde reductase, NADP+-dependent aldehyde reductase, NADPH-aldehyde reductase, NADPH-dependent aldehyde reductase, nonspecific succinic semialdehyde reductase, ALR 1, low-Km aldehyde reductase, high-Km aldehyde reductase, alcohol dehydrogenase (NADP)

Enzyme Commission Summary:
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19, glucuronate reductase, EC 1.1.1.33, mevaldate reductase (NADPH) and EC 1.1.1.55, lactaldehyde reductase (NADPH). Re-specific with respect to NADPH.

Citations: [Bosron72, Tabakoff70, Murata85, Chen03b]

Gene-Reaction Schematic: ?

Instance reaction of [an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+] (1.2.1.4):
i3: acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+ (1.2.1.4)

Instance reactions of [an alcohol + NADP+ = an aldehyde + NADPH + H+] (1.1.1.2):
i1: (S)-propane-1,2-diol + NADP+ = (S)-lactaldehyde + NADPH + H+ (1.1.1.-)

i2: (R)-propane-1,2-diol + NADP+ = (R)-lactaldehyde + NADPH + H+ (1.1.1.-)

Relationship Links: BRENDA:EC:1.1.1.2 , ENZYME:EC:1.1.1.2 , IUBMB-ExplorEnz:EC:1.1.1.2


References

Bosron72: Bosron WF, Prairie RL (1972). "Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex." J Biol Chem 247(14);4480-5. PMID: 4402936

Chen03b: Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH (2003). "Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae." Yeast 20(6);545-54. PMID: 12722185

Murata85: Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A (1985). "Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae." Eur J Biochem 151(3);631-6. PMID: 3896793

Tabakoff70: Tabakoff B, Erwin VG (1970). "Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain." J Biol Chem 245(12);3263-8. PMID: 4393513


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.