|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: L-arabinose degradation I
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: L-arabinose isomerase
Enzyme Commission Synonyms: L-arabinose ketol-isomerase, araA (gene name)
The first step of L-arabinose catabolism after it is transported into the cell.
Enzyme Commission Summary:
Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+) [Patrick68]. The enzyme binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [Banerjee95]. The enzyme can also convert D-galactopyranose to keto-D-tagatose with lower efficiency [Cheetham93].
Manjasetty06: Manjasetty BA, Chance MR (2006). "Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production." J Mol Biol 360(2);297-309. PMID: 16756997
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