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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: 4.1.1.19

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.19

Enzymes and Genes:
arginine decarboxylase, degradative Inferred from experiment : adiA
arginine decarboxylase, biosynthetic Inferred from experiment : speA

In Pathway: arginine degradation III (arginine decarboxylase/agmatinase pathway) , putrescine biosynthesis I , arginine dependent acid resistance

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: arginine decarboxylase

Enzyme Commission Synonyms: SpeA, L-arginine carboxy-lyase

Summary:
This is the first step in the biosynthesis of spermidine from arginine.

Enzyme Commission Summary:
A pyridoxal-phosphate protein.

Citations: [Taylor45, Ramakrishna75, Blethen68]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:4.1.1.19 , ENZYME:EC:4.1.1.19 , IUBMB-ExplorEnz:EC:4.1.1.19


References

Blethen68: Blethen SL, Boeker EA, Snell EE (1968). "Argenine decarboxylase from Escherichia coli. I. Purification and specificity for substrates and coenzyme." J Biol Chem 1968;243(8);1671-7. PMID: 4870599

Ramakrishna75: Ramakrishna S, Adiga PR (1975). "Arginine decarboxylase from Lathyrus sativus seedlings. Purification and properites." Eur J Biochem 59(2);377-86. PMID: 1252

Taylor45: Taylor ES, Gale EF (1945). "Studies on bacterial amino-acid decarboxylases: 6. Codecarboxylase content and action of inhibitors." Biochem J 39(1);52-8. PMID: 16747854


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc13.