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Escherichia coli K-12 substr. MG1655 Reaction: 4.1.1.19


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 4.1.1.19

Enzymes and Genes:
arginine decarboxylase, degradativeInferred from experiment: adiA
arginine decarboxylase, biosyntheticInferred from experiment: speA

In Pathway: L-arginine degradation III (arginine decarboxylase/agmatinase pathway), putrescine biosynthesis I, arginine dependent acid resistance

Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: arginine decarboxylase

Enzyme Commission Synonyms: SpeA, L-arginine carboxy-lyase

Summary:
This is the first step in the biosynthesis of spermidine from arginine.

Enzyme Commission Summary:
A pyridoxal-phosphate protein.

Citations: [Taylor45, Ramakrishna75, Blethen68]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:4.1.1.19, ENZYME:EC:4.1.1.19, IUBMB-ExplorEnz:EC:4.1.1.19


References

Blethen68: Blethen SL, Boeker EA, Snell EE (1968). "Argenine decarboxylase from Escherichia coli. I. Purification and specificity for substrates and coenzyme." J Biol Chem 1968;243(8);1671-7. PMID: 4870599

Ramakrishna75: Ramakrishna S, Adiga PR (1975). "Arginine decarboxylase from Lathyrus sativus seedlings. Purification and properites." Eur J Biochem 59(2);377-86. PMID: 1252

Taylor45: Taylor ES, Gale EF (1945). "Studies on bacterial amino-acid decarboxylases: 6. Codecarboxylase content and action of inhibitors." Biochem J 39(1);52-8. PMID: 16747854


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed May 4, 2016, biocyc13.