|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
In Pathway: L-arginine degradation II (AST pathway)
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: arginine N-succinyltransferase
Enzyme Commission Synonyms: arginine succinyltransferase, AstA, arginine and ornithine N2-succinyltransferase, AOST, AST, succinyl-CoA:L-arginine 2-N-succinyltransferase
Enzyme Commission Summary:
Also acts on L-ornithine. This is the first enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [Vander88]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 220.127.116.11 (arginine N-succinyltransferase), EC 18.104.22.168 (N-succinylarginine dihydrolase), EC 22.214.171.124 (succinylornithine transaminase), EC 126.96.36.199 (succinylglutamate-semialdehyde dehydrogenase) and EC 188.8.131.52 (succinylglutamate desuccinylase) [Vander85, Cunin86].
Itoh97: Itoh Y (1997). "Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa." J Bacteriol 179(23);7280-90. PMID: 9393691
Tricot94: Tricot C, Vander Wauven C, Wattiez R, Falmagne P, Stalon V (1994). "Purification and properties of a succinyltransferase from Pseudomonas aeruginosa specific for both arginine and ornithine." Eur J Biochem 224(3);853-61. PMID: 7523119
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