Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
asparagine synthetase BInferred from experiment: asnB
asparagine synthetase AInferred from experiment: asnA

Sub-reaction of: L-glutamine + L-aspartate + ATP + H2O → L-glutamate + L-asparagine + AMP + diphosphate + H+

In Pathway: L-asparagine biosynthesis II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aspartate—ammonia ligase

Enzyme Commission Synonyms: asparagine synthetase, L-asparagine synthetase

This is one of two reactions in E. coli that synthesizes asparagine from aspartate. The other reaction uses glutamine as the preferred nitrogen donor.

Citations: [RAVEL62, Webster55]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


RAVEL62: RAVEL JM, NORTON SJ, HUMPHREYS JS, SHIVE W (1962). "Asparagine biosynthesis in Lactobacillus arabinosus and its control by asparagine through enzyme inhibition and repression." J Biol Chem 237;2845-9. PMID: 14490631

Webster55: Webster GC, Varner JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems." J Biol Chem 215(1);91-9. PMID: 14392145

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Dec 1, 2015, biocyc13.