Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 6.3.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 6.3.1.1

Enzymes and Genes:
asparagine synthetase B Inferred from experiment : asnB
asparagine synthetase A Inferred from experiment : asnA

Sub-reaction of:
6.3.5.4: L-glutamine + L-aspartate + ATP + H2O → L-glutamate + L-asparagine + AMP + diphosphate + H+

In Pathway: asparagine biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aspartate—ammonia ligase

Enzyme Commission Synonyms: asparagine synθse, L-asparagine synθse

Summary:
This is one of two reactions in E. coli that synthesizes asparagine from aspartate. The other reaction uses glutamine as the preferred nitrogen donor.

Citations: [RAVEL62, WEBSTER55]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:6.3.1.1 , ENZYME:EC:6.3.1.1 , IUBMB-ExplorEnz:EC:6.3.1.1


References

RAVEL62: RAVEL JM, NORTON SJ, HUMPHREYS JS, SHIVE W (1962). "Asparagine biosynthesis in Lactobacillus arabinosus and its control by asparagine through enzyme inhibition and repression." J Biol Chem 237;2845-9. PMID: 14490631

WEBSTER55: WEBSTER GC, VARNER JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems." J Biol Chem 215(1);91-9. PMID: 14392145


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13A.