|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Marked as unbalanced.
In this reaction chemotaxis regulator protein CheY is dephosphorylated. The CheZ protein accelerates the reaction.
The dephosphorylation of phospho-CheY does not depend upon the presence of CheA or any other protein. However in the presence of CheZ protein the reaction is greatly accelerated. Mg++ is required for dephosphorylation and is tightly bound to the protein. Other metal cations can substitute for Mg++. [Neidhardt96, Lukat90, Volz91, Hoch95]Ca2+ [Comment 1]
Filimonov93: Filimonov VV, Prieto J, Martinez JC, Bruix M, Mateo PL, Serrano L (1993). "Thermodynamic analysis of the chemotactic protein from Escherichia coli, CheY." Biochemistry 1993;32(47);12906-21. PMID: 8251514
Lukat90: Lukat GS, Stock AM, Stock JB (1990). "Divalent metal ion binding to the CheY protein and its significance to phosphotransfer in bacterial chemotaxis." Biochemistry 1990;29(23);5436-42. PMID: 2201404
Neidhardt96: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE "Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition." American Society for Microbiology, Washington, D.C., 1996.
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