Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 4.1.3.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.3.6

Enzymes and Genes:
citrate lyase Inferred from experiment : citD , citF , citE

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: citrate (pro-3S)-lyase

Enzyme Commission Synonyms: citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]

Sub-reactions:
an acetyl-[holo citrate lyase acyl-carrier protein] + citrate → a citryl-[holo citrate lyase acyl-carrier protein] + acetate ,
a citryl-[holo citrate lyase acyl-carrier protein] → oxaloacetate + an acetyl-[holo citrate lyase acyl-carrier protein]

Summary:
This overall reaction is carried out by the citrate lyase multienzyme complex. The reaction proceeds in two steps, each one catalyzed by a separate subunit of the enzyme complex.

Enzyme Commission Summary:
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10, citrate CoA-transferase and EC 4.1.3.34, citryl-CoA lyase. EC 3.1.2.16, citrate lyase deacetylase deacetylates and inactivates the enzyme.

Citations: [Dimroth77, DAGLEY55]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:4.1.3.6 , ENZYME:EC:4.1.3.6 , IUBMB-ExplorEnz:EC:4.1.3.6


References

DAGLEY55: DAGLEY S, DAWES EA (1955). "Citridesmolase: its properties and mode of action." Biochim Biophys Acta 17(2);177-84. PMID: 13239657

Dimroth77: Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate." Eur J Biochem 80(2);479-88. PMID: 336371


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC14A.