Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
citrate lyaseInferred from experiment: citD, citF, citE

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: citrate (pro-3S)-lyase

Enzyme Commission Synonyms: citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]

citrate + an acetyl-[holo citrate lyase acyl-carrier protein] + H+ → a citryl-[holo citrate lyase acyl-carrier protein] + acetate,
a citryl-[holo citrate lyase acyl-carrier protein] → oxaloacetate + an acetyl-[holo citrate lyase acyl-carrier protein] + H+

This overall reaction is carried out by the citrate lyase multienzyme complex. The reaction proceeds in two steps, each one catalyzed by a separate subunit of the enzyme complex.

Enzyme Commission Summary:
The enzyme can be dissociated into components, two of which are identical with EC, citrate CoA-transferase and EC, citryl-CoA lyase. EC, citrate lyase deacetylase deacetylates and inactivates the enzyme.

Citations: [Dimroth77 , DAGLEY55]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


DAGLEY55: DAGLEY S, DAWES EA (1955). "Citridesmolase: its properties and mode of action." Biochim Biophys Acta 17(2);177-84. PMID: 13239657

Dimroth77: Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate." Eur J Biochem 80(2);479-88. PMID: 336371

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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