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Escherichia coli K-12 substr. MG1655 Reaction: 3.6.1.65


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.6.1.65

Enzymes and Genes:
pyrimidine deoxynucleoside triphosphate pyrophosphohydrolaseInferred from experiment: nudI
nucleoside triphosphate pyrophosphohydrolase: mazG

In Pathway: pyrimidine deoxyribonucleotides dephosphorylation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (d)CTP diphosphatase

Enzyme Commission Synonyms: (d)CTP pyrophosphohydrolase, (d)CTP diphosphohydrolase, nudG (gene name)

Enzyme Commission Summary:
The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-CTP and 8-hydroxy-dGTP.

Citations: [OHandley01, Fujikawa02, Iida05]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside 5'-monophosphate + diphosphate + H+] (3.6.1.19):
i1: dGTP + H2O → dGMP + diphosphate + H+ (3.6.1.19)

i2: dATP + H2O → dAMP + diphosphate + H+ (3.6.1.19)

i3: dUTP + H2O → dUMP + diphosphate + H+ (3.6.1.19/3.6.1.23)

i4: XTP + H2O → XMP + diphosphate + H+ (3.6.1.66)

i5: CTP + H2O → CMP + diphosphate + H+ (3.6.1.65)

i6: dITP + H2O → dIMP + diphosphate + H+ (3.6.1.66)

i7: ATP + H2O → AMP + diphosphate + H+ (3.6.1.8)

i8: ITP + H2O → IMP + diphosphate + H+ (3.6.1.19)

i9: dCTP + H2O → dCMP + diphosphate + H+ (3.6.1.65)
i10: UTP + H2O → UMP + diphosphate + H+ (3.6.1.19)

i11: dTTP + H2O → dTMP + diphosphate + H+ (3.6.1.19)

Relationship Links: BRENDA:EC:3.6.1.65, ENZYME:EC:3.6.1.65, IUBMB-ExplorEnz:EC:3.6.1.65


References

Fujikawa02: Fujikawa K, Kasai H (2002). "The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein." DNA Repair (Amst) 1(7);571-6. PMID: 12509230

Iida05: Iida E, Satou K, Mishima M, Kojima C, Harashima H, Kamiya H (2005). "Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein." Biochemistry 44(15);5683-9. PMID: 15823026

OHandley01: O'Handley SF, Dunn CA, Bessman MJ (2001). "Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP." J Biol Chem 2001;276(8);5421-6. PMID: 11053429


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc13.