Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsDNA-Reactions

EC Number:

Enzymes and Genes:
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonucleaseInferred from experiment: polA
DNA polymerase VInferred from experiment: umuC, umuD
DNA polymerase IIInferred from experiment: polB
DNA polymerase III, α subunitInferred from experiment: dnaE
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis)Inferred from experiment: dinB

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: DNA-directed DNA polymerase

Enzyme Commission Synonyms: DNA polymerase I, DNA polymerase II, DNA polymerase III, DNA polymerase α, DNA polymerase β, DNA polymerase γ, DNA nucleotidyltransferase (DNA-directed), deoxyribonucleate nucleotidyltransferase, deoxynucleate polymerase, deoxyribonucleic acid duplicase, deoxyribonucleic acid polymerase, deoxyribonucleic duplicase, deoxyribonucleic polymerase, deoxyribonucleic polymerase I, DNA duplicase, DNA nucleotidyltransferase, DNA polymerase, DNA replicase, DNA-dependent DNA polymerase, duplicase, Klenow fragment, sequenase, Taq DNA polymerase, Taq Pol I, Tca DNA polymerase

Enzyme Commission Summary:
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC RNA-directed DNA polymerase.

Citations: [Zimmerman66, Schachman60, Richardson64, Lehman58, Falaschi66, Bollum60]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Bollum60: Bollum FJ (1960). "Calf thymus polymerase." J Biol Chem 235;2399-403. PMID: 13802334

Falaschi66: Falaschi A, Kornberg A (1966). "Biochemical studies of bacterial sporulation. II. Deoxy- ribonucleic acid polymerase in spores of Bacillus subtilis." J Biol Chem 241(7);1478-82. PMID: 4957767

Lehman58: Lehman IR, Bessman MJ, Simms ES, Kornberg A (1958). "Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli." J Biol Chem 233(1);163-70. PMID: 13563462

Richardson64: Richardson CC, Schildkraut CL, Aposhian HV, Kornberg A (1964). "Enzymatic synthesis of deoxyribonucleic acid. XIV. Further purification and properties of deoxyribonucleic acid polymerase of Escherichia coli." J Biol Chem 239;222-32. PMID: 14114848

Schachman60: Schachman HK, Adler J, Radding CM, Lehman IR, Kornberg A (1960). "Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate." J Biol Chem 235;3242-9. PMID: 13747134

Zimmerman66: Zimmerman BK (1966). "Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus." J Biol Chem 241(9);2035-41. PMID: 5946628

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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