Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 2.7.7.7

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions DNA-Reactions

EC Number: 2.7.7.7

Enzymes and Genes:
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease Inferred from experiment : polA
DNA polymerase V Inferred from experiment : umuC , umuD
DNA polymerase II Inferred from experiment : polB
DNA polymerase III, α subunit Inferred from experiment : dnaE
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis) Inferred from experiment : dinB

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: DNA-directed DNA polymerase

Enzyme Commission Synonyms: DNA polymerase I, DNA polymerase II, DNA polymerase III, DNA polymerase α, DNA polymerase β, DNA polymerase γ, DNA nucleotidyltransferase (DNA-directed), deoxyribonucleate nucleotidyltransferase, deoxynucleate polymerase, deoxyribonucleic acid duplicase, deoxyribonucleic acid polymerase, deoxyribonucleic duplicase, deoxyribonucleic polymerase, deoxyribonucleic polymerase I, DNA duplicase, DNA nucleotidyltransferase, DNA polymerase, DNA replicase, DNA-dependent DNA polymerase, duplicase, Klenow fragment, sequenase, Taq DNA polymerase, Taq Pol I, Tca DNA polymerase

Enzyme Commission Summary:
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.

Citations: [Zimmerman66, SCHACHMAN60, RICHARDSON64, Lehman58, Falaschi66, BOLLUM60]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.7.7 , ENZYME:EC:2.7.7.7 , IUBMB-ExplorEnz:EC:2.7.7.7


References

BOLLUM60: BOLLUM FJ (1960). "Calf thymus polymerase." J Biol Chem 235;2399-403. PMID: 13802334

Falaschi66: Falaschi A, Kornberg A (1966). "Biochemical studies of bacterial sporulation. II. Deoxy- ribonucleic acid polymerase in spores of Bacillus subtilis." J Biol Chem 241(7);1478-82. PMID: 4957767

Lehman58: Lehman IR, Bessman MJ, Simms ES, Kornberg A (1958). "Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli." J Biol Chem 233(1);163-70. PMID: 13563462

RICHARDSON64: RICHARDSON CC, SCHILDKRAUT CL, APOSHIAN HV, KORNBERG A (1964). "ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI." J Biol Chem 239;222-32. PMID: 14114848

SCHACHMAN60: SCHACHMAN HK, ADLER J, RADDING CM, LEHMAN IR, KORNBERG A (1960). "Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate." J Biol Chem 235;3242-9. PMID: 13747134

Zimmerman66: Zimmerman BK (1966). "Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus." J Biol Chem 241(9);2035-41. PMID: 5946628


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.