|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Polynucleotide-Reactions → DNA-Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease : polA
DNA polymerase V : umuC , umuD
DNA polymerase II : polB
DNA polymerase III, α subunit : dnaE
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis) : dinB
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: DNA-directed DNA polymerase
Enzyme Commission Synonyms: DNA polymerase I, DNA polymerase II, DNA polymerase III, DNA polymerase α, DNA polymerase β, DNA polymerase γ, DNA nucleotidyltransferase (DNA-directed), deoxyribonucleate nucleotidyltransferase, deoxynucleate polymerase, deoxyribonucleic acid duplicase, deoxyribonucleic acid polymerase, deoxyribonucleic duplicase, deoxyribonucleic polymerase, deoxyribonucleic polymerase I, DNA duplicase, DNA nucleotidyltransferase, DNA polymerase, DNA replicase, DNA-dependent DNA polymerase, duplicase, Klenow fragment, sequenase, Taq DNA polymerase, Taq Pol I, Tca DNA polymerase
Enzyme Commission Summary:
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 22.214.171.124 RNA-directed DNA polymerase.
Falaschi66: Falaschi A, Kornberg A (1966). "Biochemical studies of bacterial sporulation. II. Deoxy- ribonucleic acid polymerase in spores of Bacillus subtilis." J Biol Chem 241(7);1478-82. PMID: 4957767
Lehman58: Lehman IR, Bessman MJ, Simms ES, Kornberg A (1958). "Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli." J Biol Chem 233(1);163-70. PMID: 13563462
Richardson64: Richardson CC, Schildkraut CL, Aposhian HV, Kornberg A (1964). "Enzymatic synthesis of deoxyribonucleic acid. XIV. Further purification and properties of deoxyribonucleic acid polymerase of Escherichia coli." J Biol Chem 239;222-32. PMID: 14114848
Schachman60: Schachman HK, Adler J, Radding CM, Lehman IR, Kornberg A (1960). "Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate." J Biol Chem 235;3242-9. PMID: 13747134
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